Pharmacokinetics of a single dose of Aficamten (CK‐274) on cardiac contractility in a A31P MYBPC3 hypertrophic cardiomyopathy cat model

por Sharpe, Ashley N., Oldach, Maureen S., Kaplan, Joanna L., Rivas, Victor, Kovacs, Samantha L., Hwee, Darren T., Morgan, Bradley P., Malik, Fady I., Harris, Samantha P., Stern, Joshua A.
Publicado 2022

Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy

por Sharpe, Ashley N., Oldach, Maureen S., Rivas, Victor N., Kaplan, Joanna L., Walker, Ashley L., Kovacs, Samantha L., Hwee, Darren T., Cremin, Peadar, Morgan, Bradley P., Malik, Fady I., Harris, Samantha P., Stern, Joshua A.
Publicado 2023

Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator

por Collibee, Scott E., Bergnes, Gustave, Muci, Alexander, Browne, William F., Garard, Marc, Hinken, Aaron C., Russell, Alan J., Suehiro, Ion, Hartman, James, Kawas, Raja, Lu, Pu-Ping, Lee, Kenneth H., Marquez, David, Tomlinson, Matthew, Xu, Donghong, Kennedy, Adam, Hwee, Darren, Schaletzky, Julia, Leung, Kwan, Malik, Fady I., Morgans, David J., Morgan, Bradley P.
Publicado 2018

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

por Metcalf, Brian, Chuang, Chihyuan, Dufu, Kobina, Patel, Mira P., Silva-Garcia, Abel, Johnson, Carl, Lu, Qing, Partridge, James R., Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C., Jacobson, Matthew P., Hua, Lan, Xu, Qing, Gwaltney, Stephen L., Yee, Calvin, Harris, Jason, Morgan, Bradley P., James, Joyce, Xu, Donghong, Hutchaleelaha, Athiwat, Paulvannan, Kumar, Oksenberg, Donna, Li, Zhe
Publicado 2017

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases

por Russell, Alan J, Hartman, James J, Hinken, Aaron C, Muci, Alexander R, Kawas, Raja, Driscoll, Lena, Godinez, Guillermo, Lee, Kenneth H, Marquez, David, Browne, William F, Chen, Michael M, Clarke, David, Collibee, Scott E, Garard, Marc, Hansen, Richard, Jia, Zhiheng, Lu, Pu-Ping, Rodriguez, Hector, Saikali, Khalil G, Schaletzky, Julia, Vijayakumar, Vipin, Albertus, Daniel L, Claflin, Dennis R, Morgans, David J, Morgan, Bradley P, Malik, Fady I
Publicado 2012