Ambushing the ambush hypothesis: predicting and evaluating off-frame codon frequencies in Prokaryotic Genomes

por Morgens, David W, Chang, Charlotte H, Cavalcanti, Andre RO
Publicado 2013

Systematic comparison of CRISPR-Cas9 and RNAi screens for essential genes

por Morgens, David W, Deans, Richard M, Li, Amy, Bassik, Michael C
Publicado 2016

A Model for the Evolution of Extremely Fragmented Macronuclei in Ciliates

por Morgens, David W., Lindbergh, Kristen M., Adachi, Marie, Radunskaya, Ami, Cavalcanti, Andre R. O.
Publicado 2013

A Two-tiered functional screen identifies herpesviral transcriptional modifiers and their essential domains

por Morgens, David W., Nandakumar, Divya, Didychuk, Allison L., Yang, Kevin J., Glaunsinger, Britt A.
Publicado 2022

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

por Han, Kyuho, Jeng, Edwin E., Hess, Gaelen T., Morgens, David W., Li, Amy, Bassik, Michael C.
Publicado 2017

Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs

por Lu, Albert, Wawro, Paulina, Morgens, David W, Portela, Fernando, Bassik, Michael C, Pfeffer, Suzanne R
Publicado 2018

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

por Breslow, David K., Hoogendoorn, Sascha, Kopp, Adam R., Morgens, David W., Vu, Brandon K., Kennedy, Margaret C., Han, Kyuho, Li, Amy, Hess, Gaelen T., Bassik, Michael C., Chen, James K., Nachury, Maxence V.
Publicado 2018

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

por Deans, Richard M., Morgens, David W., Ökesli, Ayşe, Pillay, Sirika, Horlbeck, Max A., Kampmann, Martin, Gilbert, Luke A., Li, Amy, Mateo, Roberto, Smith, Mark, Glenn, Jeffrey S., Carette, Jan E., Khosla, Chaitan, Bassik, Michael C.
Publicado 2016

Functional characterization of the PI3K/AKT/MTOR signaling pathway for targeted therapy in B-precursor acute lymphoblastic leukemia

por Grüninger, Patricia K., Uhl, Franziska, Herzog, Heike, Gentile, Gaia, Andrade-Martinez, Marta, Schmidt, Tobias, Han, Kyuho, Morgens, David W., Bassik, Michael C., Cleary, Michael L., Gorka, Oliver, Zeiser, Robert, Groß, Olaf, Duque-Afonso, Jesús
Publicado 2022

Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

por Morgens, David W., Wainberg, Michael, Boyle, Evan A., Ursu, Oana, Araya, Carlos L., Tsui, C. Kimberly, Haney, Michael S., Hess, Gaelen T., Han, Kyuho, Jeng, Edwin E., Li, Amy, Snyder, Michael P., Greenleaf, William J., Kundaje, Anshul, Bassik, Michael C.
Publicado 2017

The N(6)-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity

por Yoshinaga, Masanori, Han, Kyuho, Morgens, David W., Horii, Takuro, Kobayashi, Ryosuke, Tsuruyama, Tatsuaki, Hia, Fabian, Yasukura, Shota, Kajiya, Asako, Cai, Ting, Cruz, Pedro H. C., Vandenbon, Alexis, Suzuki, Yutaka, Kawahara, Yukio, Hatada, Izuho, Bassik, Michael C., Takeuchi, Osamu
Publicado 2022

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9orf72 dipeptide repeat protein toxicity

por Kramer, Nicholas J., Haney, Michael S., Morgens, David W., Jovičić, Ana, Couthouis, Julien, Li, Amy, Ousey, James, Ma, Rosanna, Bieri, Gregor, Tsui, C. Kimberly, Shi, Yingxiao, Hertz, Nicholas T., Tessier-Lavigne, Marc, Ichida, Justin K., Bassik, Michael C., Gitler, Aaron D.
Publicado 2018

Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain

por Marschallinger, Julia, Iram, Tal, Zardeneta, Macy, Lee, Song E., Lehallier, Benoit, Haney, Michael S., Pluvinage, John V., Mathur, Vidhu, Hahn, Oliver, Morgens, David W., Kim, Justin, Tevini, Julia, Felder, Thomas K., Wolinski, Heimo, Bertozzi, Carolyn R., Bassik, Michael C., Aigner, Ludwig, Wyss-Coray, Tony
Publicado 2020

CD22 blockade restores homeostatic microglial phagocytosis in aging brains

por Pluvinage, John V., Haney, Michael S., Smith, Benjamin A. H., Sun, Jerry, Iram, Tal, Bonanno, Liana, Li, Lulin, Lee, Davis P., Morgens, David W., Yang, Andrew C., Shuken, Steven R., Gate, David, Scott, Madeleine, Khatri, Purvesh, Luo, Jian, Bertozzi, Carolyn R., Bassik, Michael C., Wyss-Coray, Tony
Publicado 2019

Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion

por Prolo, Laura M., Li, Amy, Owen, Scott F., Parker, Jonathon J., Foshay, Kara, Nitta, Ryan T., Morgens, David W., Bolin, Sara, Wilson, Christy M., Vega L, Johana C. M., Luo, Emily J., Nwagbo, Gigi, Waziri, Allen, Li, Gordon, Reimer, Richard J., Bassik, Michael C., Grant, Gerald A.
Publicado 2019

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

por Morgens, David W, Chan, Charlene, Kane, Andrew J, Weir, Nicholas R, Li, Amy, Dubreuil, Michael M, Tsui, C Kimberly, Hess, Gaelen T, Lavertu, Adam, Han, Kyuho, Polyakov, Nicole, Zhou, Jing, Handy, Emma L, Alabi, Philip, Dombroski, Amanda, Yao, David, Altman, Russ B, Sello, Jason K, Denic, Vladimir, Bassik, Michael C
Publicado 2019

Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements

por Tycko, Josh, Wainberg, Michael, Marinov, Georgi K., Ursu, Oana, Hess, Gaelen T., Ego, Braeden K., Aradhana, Li, Amy, Truong, Alisa, Trevino, Alexandro E., Spees, Kaitlyn, Yao, David, Kaplow, Irene M., Greenside, Peyton G., Morgens, David W., Phanstiel, Douglas H., Snyder, Michael P., Bintu, Lacramioara, Greenleaf, William J., Kundaje, Anshul, Bassik, Michael C.
Publicado 2019