Enteropeptidase inhibition improves kidney function in a rat model of diabetic kidney disease

por Sugama, Jun, Katayama, Yuko, Moritoh, Yusuke, Watanabe, Masanori
Publicado 2020

Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, ameliorates type 2 diabetes via reduced gluconeogenesis

por Katayama, Yuko, Kawata, Yayoi, Moritoh, Yusuke, Watanabe, Masanori
Publicado 2022

An Exploratory Randomized Trial of SCO-792, an Enteropeptidase Inhibitor, in Patients With Type 2 Diabetes and Albuminuria

por Kagawa, Tomoya, Sugama, Jun, Nishizaki, Harunobu, Moritoh, Yusuke, Watanabe, Masanori
Publicado 2022

SCO-267, a GPR40 Full Agonist, Stimulates Islet and Gut Hormone Secretion and Improves Glycemic Control in Humans

por Nishizaki, Harunobu, Matsuoka, Osamu, Kagawa, Tomoya, Kobayashi, Akihiro, Watanabe, Masanori, Moritoh, Yusuke
Publicado 2021

Inositol Hexakisphosphate Kinase 3 Regulates Metabolism and Lifespan in Mice

por Moritoh, Yusuke, Oka, Masahiro, Yasuhara, Yoshitaka, Hozumi, Hiroyuki, Iwachidow, Kimihiko, Fuse, Hiromitsu, Tozawa, Ryuichi
Publicado 2016

Enteropeptidase inhibitor SCO-792 effectively prevents kidney function decline and fibrosis in a rat model of chronic kidney disease

por Katayama, Yuko, Sugama, Jun, Suzuki, Tomohisa, Ishimura, Yoshimasa, Kobayashi, Akihiro, Moritoh, Yusuke, Watanabe, Masanori
Publicado 2020

The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals

por Moritoh, Yusuke, Abe, Shin-ichi, Akiyama, Hiroki, Kobayashi, Akihiro, Koyama, Ryokichi, Hara, Ryoma, Kasai, Shizuo, Watanabe, Masanori
Publicado 2021

Nuclear Hormone Retinoid X Receptor (RXR) Negatively Regulates the Glucose-Stimulated Insulin Secretion of Pancreatic β-Cells

por Miyazaki, Satsuki, Taniguchi, Hidenori, Moritoh, Yusuke, Tashiro, Fumi, Yamamoto, Tsunehiko, Yamato, Eiji, Ikegami, Hiroshi, Ozato, Keiko, Miyazaki, Jun-ichi
Publicado 2010

SCO‐792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice

por Yashiro, Hiroaki, Hamagami, Kenichi, Hiyoshi, Hideyuki, Sugama, Jun, Tsuchimori, Kazue, Yamaguchi, Fuminari, Moritoh, Yusuke, Sasaki, Minoru, Maekawa, Tsuyoshi, Yamada, Yukio, Watanabe, Masanori
Publicado 2019

GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve

por Ueno, Hikaru, Ito, Ryo, Abe, Shin-ichi, Ogino, Hitomi, Maruyama, Minoru, Miyashita, Hirohisa, Miyamoto, Yasufumi, Moritoh, Yusuke, Tsujihata, Yoshiyuki, Takeuchi, Koji, Nishigaki, Nobuhiro
Publicado 2019

Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792

por Sasaki, Masako, Miyahisa, Ikuo, Itono, Sachiko, Yashiro, Hiroaki, Hiyoshi, Hideyuki, Tsuchimori, Kazue, Hamagami, Ken‐ichi, Moritoh, Yusuke, Watanabe, Masanori, Tohyama, Kimio, Sasaki, Minoru, Sakamoto, Jun‐ichi, Kawamoto, Tomohiro
Publicado 2019

GLP‐1 suppresses glucagon secretion in human pancreatic alpha‐cells by inhibition of P/Q‐type Ca(2+) channels

por Ramracheya, Reshma, Chapman, Caroline, Chibalina, Margarita, Dou, Haiqiang, Miranda, Caroline, González, Alejandro, Moritoh, Yusuke, Shigeto, Makoto, Zhang, Quan, Braun, Matthias, Clark, Anne, Johnson, Paul R., Rorsman, Patrik, Briant, Linford J. B.
Publicado 2018