Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosis

por Yamane, Mototeru, Moriya, Shota, Kokuba, Hiroko
Publicado 2017

Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression

por Moriya, Shota, Kazama, Hiromi, Hino, Hirotsugu, Takano, Naoharu, Hiramoto, Masaki, Aizawa, Shin, Miyazawa, Keisuke
Publicado 2023

Cell proliferation potency is independent of FGF4 signaling in trophoblast stem cells derived from androgenetic embryos

por OGAWA, Hidehiko, TAKYU, Ryuichi, MORIMOTO, Hiromu, TOEI, Shuntaro, SAKON, Hiroshi, GOTO, Shiori, MORIYA, Shota, KONO, Tomohiro
Publicado 2015

Induction of synergistic non-apoptotic cell death by simultaneously targeting proteasomes with bortezomib and histone deacetylase 6 with ricolinostat in head and neck tumor cells

por Hattori, Kazuhiro, Takano, Naoharu, Kazama, Hiromi, Moriya, Shota, Miyake, Keitaro, Hiramoto, Masaki, Tsukahara, Kiyoaki, Miyazawa, Keisuke
Publicado 2021

Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells

por Toriyama, Kazutoshi, Takano, Naoharu, Kokuba, Hiroko, Kazama, Hiromi, Moriya, Shota, Hiramoto, Masaki, Abe, Shinji, Miyazawa, Keisuke
Publicado 2021

Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells

por KOMATSU, SEIICHIRO, MIYAZAWA, KEISUKE, MORIYA, SHOTA, TAKASE, AKIKO, NAITO, MUNEKAZU, INAZU, MASATO, KOHNO, NORIO, ITOH, MASAHIRO, TOMODA, AKIO
Publicado 2011

Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with az...

por Tanaka, Hideki, Hino, Hirotsugu, Moriya, Shota, Kazama, Hiromi, Miyazaki, Masaya, Takano, Naoharu, Hiramoto, Masaki, Tsukahara, Kiyoaki, Miyazawa, Keisuke
Publicado 2020

Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes

por Hino, Hirotsugu, Iriyama, Noriyoshi, Kokuba, Hiroko, Kazama, Hiromi, Moriya, Shota, Takano, Naoharu, Hiramoto, Masaki, Aizawa, Shin, Miyazawa, Keisuke
Publicado 2020

Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization-associated cell death

por Takeda, Atsuo, Takano, Naoharu, Kokuba, Hiroko, Hino, Hirotsugu, Moriya, Shota, Abe, Akihisa, Hiramoto, Masaki, Tsukahara, Kiyoaki, Miyazawa, Keisuke
Publicado 2020

Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells

por MORIYA, SHOTA, CHE, XIAO-FANG, KOMATSU, SEIICHIRO, ABE, AKIHISA, KAWAGUCHI, TOMOHIRO, GOTOH, AKIHIKO, INAZU, MASATO, TOMODA, AKIO, MIYAZAWA, KEISUKE
Publicado 2013

Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines

por Hirasawa, Kazuhiro, Moriya, Shota, Miyahara, Kana, Kazama, Hiromi, Hirota, Ayako, Takemura, Jun, Abe, Akihisa, Inazu, Masato, Hiramoto, Masaki, Tsukahara, Kiyoaki, Miyazawa, Keisuke
Publicado 2016

Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress-mediated cell death in multiple myeloma cells

por MORIYA, SHOTA, KOMATSU, SEIICHIRO, YAMASAKI, KAHO, KAWAI, YUSUKE, KOKUBA, HIROKO, HIROTA, AYAKO, CHE, XIAO-FANG, INAZU, MASATO, GOTOH, AKIHIKO, HIRAMOTO, MASAKI, MIYAZAWA, KEISUKE
Publicado 2014

Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines

por Miyahara, Kana, Kazama, Hiromi, Kokuba, Hiroko, Komatsu, Seiichiro, Hirota, Ayako, Takemura, Jun, Hirasawa, Kazuhiro, Moriya, Shota, Abe, Akihisa, Hiramoto, Masaki, Ishikawa, Takashi, Miyazawa, Keisuke
Publicado 2016

Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis

por Saito, Yu, Moriya, Shota, Kazama, Hiromi, Hirasawa, Kazuhiro, Miyahara, Kana, Kokuba, Hiroko, Hino, Hirotsugu, Kikuchi, Hiroyuki, Takano, Naoharu, Hiramoto, Masaki, Tsukahara, Kiyoaki, Miyazawa, Keisuke
Publicado 2018

Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines

por MUKAI, SHUNTARO, MORIYA, SHOTA, HIRAMOTO, MASAKI, KAZAMA, HIROMI, KOKUBA, HIROKO, CHE, XIAO-FANG, YOKOYAMA, TOMOHISA, SAKAMOTO, SATOSHI, SUGAWARA, AKIHIRO, SUNAZUKA, TOSHIAKI, ŌMURA, SATOSHI, HANDA, HIROSHI, ITOI, TAKAO, MIYAZAWA, KEISUKE
Publicado 2015

Specific autoantigens identified by sera obtained from mice that are immunized with testicular germ cells alone

por Terayama, Hayato, Hirai, Shuichi, Naito, Munekazu, Qu, Ning, Katagiri, Chiaki, Nagahori, Kenta, Hayashi, Shogo, Sasaki, Hiraku, Moriya, Shota, Hiramoto, Masaki, Miyazawa, Keisuke, Hatayama, Naoyuki, Li, Zhong-Lian, Sakabe, Kou, Matsushita, Masayuki, Itoh, Masahiro
Publicado 2016