Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk

por Morotti, Stefano, Grandi, Eleonora
Publicado 2016

Ca(2+) current facilitation is CaMKII-dependent and has arrhythmogenic consequences

por Bers, Donald M., Morotti, Stefano
Publicado 2014

A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research

por Ni, Haibo, Morotti, Stefano, Grandi, Eleonora
Publicado 2018

In Silico Assessment of Efficacy and Safety of I(Kur) Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding

por Ellinwood, Nicholas, Dobrev, Dobromir, Morotti, Stefano, Grandi, Eleonora
Publicado 2017

Editorial: Safety Pharmacology – Risk Assessment QT Interval Prolongation and Beyond

por Grandi, Eleonora, Morotti, Stefano, Pueyo, Esther, Rodriguez, Blanca
Publicado 2018

Dual effects of the small-conductance Ca(2+)-activated K(+) current on human atrial electrophysiology and Ca(2+)-driven arrhythmogenesis: an in silico study

por Herrera, Nathaniel T., Zhang, Xianwei, Ni, Haibo, Maleckar, Mary M., Heijman, Jordi, Dobrev, Dobromir, Grandi, Eleonora, Morotti, Stefano
Publicado 2023

The funny current I(f) is essential for the fight-or-flight response in cardiac pacemaker cells

por Peters, Colin H., Rickert, Christian, Morotti, Stefano, Grandi, Eleonora, Aronow, Kurt A., Beam, Kurt G., Proenza, Catherine
Publicado 2022

Intracellular Na(+) Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis

por Morotti, Stefano, Ni, Haibo, Peters, Colin H., Rickert, Christian, Asgari-Targhi, Ameneh, Sato, Daisuke, Glukhov, Alexey V., Proenza, Catherine, Grandi, Eleonora
Publicado 2021

A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources

por Kernik, Divya C., Morotti, Stefano, Wu, HaoDi, Garg, Priyanka, Duff, Henry J., Kurokawa, Junko, Jalife, José, Wu, Joseph C., Grandi, Eleonora, Clancy, Colleen E.
Publicado 2019

Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications

por Morotti, Stefano, Liu, Caroline, Hegyi, Bence, Ni, Haibo, Fogli Iseppe, Alex, Wang, Lianguo, Pritoni, Marco, Ripplinger, Crystal M., Bers, Donald M., Edwards, Andrew G., Grandi, Eleonora
Publicado 2021

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

por Surdo, Nicoletta C., Berrera, Marco, Koschinski, Andreas, Brescia, Marcella, Machado, Matias R., Carr, Carolyn, Wright, Peter, Gorelik, Julia, Morotti, Stefano, Grandi, Eleonora, Bers, Donald M., Pantano, Sergio, Zaccolo, Manuela
Publicado 2017

Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes

por Tazmini, Kiarash, Frisk, Michael, Lewalle, Alexandre, Laasmaa, Martin, Morotti, Stefano, Lipsett, David B., Manfra, Ornella, Skogestad, Jonas, Aronsen, Jan M., Sejersted, Ole M., Sjaastad, Ivar, Edwards, Andrew G., Grandi, Eleonora, Niederer, Steven A., Øie, Erik, Louch, William E.
Publicado 2020

A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene

por Ding, Yonghe, Lang, Di, Yan, Jianhua, Bu, Haisong, Li, Hongsong, Jiao, Kunli, Yang, Jingchun, Ni, Haibo, Morotti, Stefano, Le, Tai, Clark, Karl J, Port, Jenna, Ekker, Stephen C, Cao, Hung, Zhang, Yuji, Wang, Jun, Grandi, Eleonora, Li, Zhiqiang, Shi, Yongyong, Li, Yigang, Glukhov, Alexey V, Xu, Xiaolei
Publicado 2022

CaMKIIδC Drives Early Adaptive Ca(2+) Change and Late Eccentric Cardiac Hypertrophy

por Ljubojevic-Holzer, Senka, Herren, Anthony W., Djalinac, Natasa, Voglhuber, Julia, Morotti, Stefano, Holzer, Michael, Wood, Brent M., Abdellatif, Mahmoud, Matzer, Ingrid, Sacherer, Michael, Radulovic, Snjezana, Wallner, Markus, Ivanov, Milan, Wagner, Stefan, Sossalla, Samuel, von Lewinski, Dirk, Pieske, Burkert, Brown, Joan Heller, Sedej, Simon, Bossuyt, Julie, Bers, Donald M.
Publicado 2020

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

por Li, Zhihua, Mirams, Gary R., Yoshinaga, Takashi, Ridder, Bradley J., Han, Xiaomei, Chen, Janell E., Stockbridge, Norman L., Wisialowski, Todd A., Damiano, Bruce, Severi, Stefano, Morissette, Pierre, Kowey, Peter R., Holbrook, Mark, Smith, Godfrey, Rasmusson, Randall L., Liu, Michael, Song, Zhen, Qu, Zhilin, Leishman, Derek J., Steidl‐Nichols, Jill, Rodriguez, Blanca, Bueno‐Orovio, Alfonso, Zhou, Xin, Passini, Elisa, Edwards, Andrew G., Morotti, Stefano, Ni, Haibo, Grandi, Eleonora, Clancy, Colleen E., Vandenberg, Jamie, Hill, Adam, Nakamura, Mikiko, Singer, Thomas, Polonchuk, Liudmila, Greiter‐Wilke, Andrea, Wang, Ken, Nave, Stephane, Fullerton, Aaron, Sobie, Eric A., Paci, Michelangelo, Musuamba Tshinanu, Flora, Strauss, David G.
Publicado 2019