Targeting USP-7 by a Novel Fluorinated 5-Pyrazolyl-Urea Derivative

por Morretta, Elva, Brullo, Chiara, Belvedere, Raffaella, Petrella, Antonello, Spallarossa, Andrea, Monti, Maria Chiara
Publicado 2023

Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches

por Morretta, Elva, Esposito, Roberta, Festa, Carmen, Riccio, Raffaele, Casapullo, Agostino, Monti, Maria Chiara
Publicado 2017

The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs

por Belvedere, Raffaella, Morretta, Elva, Novizio, Nunzia, Morello, Silvana, Bruno, Olga, Brullo, Chiara, Petrella, Antonello
Publicado 2021

Role of Intracellular and Extracellular Annexin A1 in MIA PaCa-2 Spheroids Formation and Drug Sensitivity

por Novizio, Nunzia, Belvedere, Raffaella, Morretta, Elva, Tomasini, Richard, Monti, Maria Chiara, Morello, Silvana, Petrella, Antonello
Publicado 2022

Label-Free Quantitative Proteomics to Explore the Action Mechanism of the Pharmaceutical-Grade Triticum vulgare Extract in Speeding Up Keratinocyte Healing

por Morretta, Elva, D’Agostino, Antonella, Cassese, Elisabetta, Maglione, Barbara, Petrella, Antonello, Schiraldi, Chiara, Monti, Maria Chiara
Publicado 2022

Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite

por Ceccacci, Sara, Deitersen, Jana, Mozzicafreddo, Matteo, Morretta, Elva, Proksch, Peter, Wesselborg, Sebastian, Stork, Björn, Monti, Maria Chiara
Publicado 2020

Drug affinity-responsive target stability unveils filamins as biological targets for artemetin, an anti-cancer flavonoid

por Ferraro, Giusy, Belvedere, Raffaella, Petrella, Antonello, Tosco, Alessandra, Stork, Björn, Salamone, Stefano, Minassi, Alberto, Pollastro, Federica, Morretta, Elva, Monti, Maria Chiara
Publicado 2022

Curcumin Has Beneficial Effects on Lysosomal Alpha-Galactosidase: Potential Implications for the Cure of Fabry Disease

por Monticelli, Maria, Hay Mele, Bruno, Allocca, Mariateresa, Liguori, Ludovica, Lukas, Jan, Monti, Maria Chiara, Morretta, Elva, Cubellis, Maria Vittoria, Andreotti, Giuseppina
Publicado 2023

Drug Repositioning for Fabry Disease: Acetylsalicylic Acid Potentiates the Stabilization of Lysosomal Alpha-Galactosidase by Pharmacological Chaperones

por Monticelli, Maria, Liguori, Ludovica, Allocca, Mariateresa, Bosso, Andrea, Andreotti, Giuseppina, Lukas, Jan, Monti, Maria Chiara, Morretta, Elva, Cubellis, Maria Vittoria, Hay Mele, Bruno
Publicado 2022

Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD-1 agents

por Turiello, Roberta, Capone, Mariaelena, Morretta, Elva, Monti, Maria Chiara, Madonna, Gabriele, Azzaro, Rosa, Del Gaudio, Pasquale, Simeone, Ester, Sorrentino, Antonio, Ascierto, Paolo A, Morello, Silvana
Publicado 2022

Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation

por Carino, Adriana, Marchianò, Silvia, Biagioli, Michele, Fiorucci, Chiara, Zampella, Angela, Monti, Maria Chiara, Morretta, Elva, Bordoni, Martina, Di Giorgio, Cristina, Roselli, Rosalinda, Ricci, Patrizia, Distrutti, Eleonora, Fiorucci, Stefano
Publicado 2019

Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH

por Marchianò, Silvia, Biagioli, Michele, Morretta, Elva, Di Giorgio, Cristina, Roselli, Rosalinda, Bordoni, Martina, Bellini, Rachele, Urbani, Ginevra, Massa, Carmen, Monti, Maria Chiara, Zampella, Angela, Distrutti, Eleonora, Fiorucci, Stefano
Publicado 2023

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma

por Di Giorgio, Cristina, Lupia, Antonio, Marchianò, Silvia, Bordoni, Martina, Bellini, Rachele, Massa, Carmen, Urbani, Ginevra, Roselli, Rosalinda, Moraca, Federica, Sepe, Valentina, Catalanotti, Bruno, Morretta, Elva, Monti, Maria Chiara, Biagioli, Michele, Distrutti, Eleonora, Zampella, Angela, Fiorucci, Stefano
Publicado 2022

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor

por Feoli, Alessandra, Iannelli, Giulia, Cipriano, Alessandra, Milite, Ciro, Shen, Lei, Wang, Zhihao, Hadjikyriacou, Andrea, Lowe, Troy L., Safaeipour, Cyrus, Viviano, Monica, Sarno, Giuliana, Morretta, Elva, Monti, Maria Chiara, Yang, Yanzhong, Clarke, Steven G., Cosconati, Sandro, Castellano, Sabrina, Sbardella, Gianluca
Publicado 2023

Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma

por Di Giorgio, Cristina, Bellini, Rachele, Lupia, Antonio, Massa, Carmen, Bordoni, Martina, Marchianò, Silvia, Rosselli, Rosalinda, Sepe, Valentina, Rapacciuolo, Pasquale, Moraca, Federica, Morretta, Elva, Ricci, Patrizia, Urbani, Ginevra, Monti, Maria Chiara, Biagioli, Michele, Distrutti, Eleonora, Catalanotti, Bruno, Zampella, Angela, Fiorucci, Stefano
Publicado 2023

Involvement of 3′,5′‐cyclic inosine monophosphate in cystathionine γ‐lyase‐dependent regulation of the vascular tone

por Mitidieri, Emma, Vellecco, Valentina, Brancaleone, Vincenzo, Vanacore, Domenico, Manzo, Onorina L., Martin, Emil, Sharina, Iraida, Krutsenko, Yekaterina, Monti, Maria Chiara, Morretta, Elva, Papapetropoulos, Andreas, Caliendo, Giuseppe, Frecentese, Francesco, Cirino, Giuseppe, Sorrentino, Raffaella, d'Emmanuele di Villa Bianca, Roberta, Bucci, Mariarosaria
Publicado 2021

Serum CD73 is a prognostic factor in patients with metastatic melanoma and is associated with response to anti-PD-1 therapy

por Turiello, Roberta, Capone, Mariaelena, Giannarelli, Diana, Morretta, Elva, Monti, Maria Chiara, Madonna, Gabriele, Mallardo, Domenico, Festino, Lucia, Azzaro, Rosa, Levesque, Mitchell P, Imhof, Laurence, Weide, Benjamin, Amaral, Teresa, Chevrier, Marc, Sucker, Antje, Rutkowski, Piotr, Schadendorf, Dirk, Lebbe, Celeste, Luke, Jason John, Wistuba-Hamprecht, Kilian, Dummer, Reinhard, Pinto, Aldo, Morello, Silvana, Ascierto, Paolo A
Publicado 2020