Pharmacology of Modulators of Alternative Splicing

por Bates, David O., Morris, Jonathan C., Oltean, Sebastian, Donaldson, Lucy F.
Publicado 2017

Vascular endothelial growth factor isoforms differentially protect neurons against neurotoxic events associated with Alzheimer’s disease

por Alalwany, Roaa H., Hawtrey, Tom, Morgan, Kevin, Morris, Jonathan C., Donaldson, Lucy F., Bates, David O.
Publicado 2023

Basal protein phosphatase 2A activity restrains cytokine expression: role for MAPKs and tristetraprolin

por Rahman, Md. Mostafizur, Rumzhum, Nowshin N., Morris, Jonathan C., Clark, Andrew R., Verrills, Nicole M., Ammit, Alaina J.
Publicado 2015

The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells

por Rahman, Md. Mostafizur, Prünte, Laura, Lebender, Leonard F., Patel, Brijeshkumar S., Gelissen, Ingrid, Hansbro, Philip M., Morris, Jonathan C., Clark, Andrew R., Verrills, Nicole M., Ammit, Alaina J.
Publicado 2016

TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis

por Collison, Adam M., Li, Junyao, de Siqueira, Ana Pereira, Lv, Xuejiao, Toop, Hamish D., Morris, Jonathan C., Starkey, Malcolm R., Hansbro, Philip M., Zhang, Jie, Mattes, Joerg
Publicado 2019

Enhancing tristetraprolin activity reduces the severity of cigarette smoke‐induced experimental chronic obstructive pulmonary disease

por Nair, Prema M, Starkey, Malcolm R, Haw, Tatt Jhong, Liu, Gang, Collison, Adam M, Mattes, Joerg, Wark, Peter A., Morris, Jonathan C, Verrills, Nikki M, Clark, Andrew R, Ammit, Alaina J, Hansbro, Philip M
Publicado 2019

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

por Turner, Nigel, Lim, Xin Ying, Toop, Hamish D., Osborne, Brenna, Brandon, Amanda E., Taylor, Elysha N., Fiveash, Corrine E., Govindaraju, Hemna, Teo, Jonathan D., McEwen, Holly P., Couttas, Timothy A., Butler, Stephen M., Das, Abhirup, Kowalski, Greg M., Bruce, Clinton R., Hoehn, Kyle L., Fath, Thomas, Schmitz-Peiffer, Carsten, Cooney, Gregory J., Montgomery, Magdalene K., Morris, Jonathan C., Don, Anthony S.
Publicado 2018

Shwachman–Bodian–Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia

por Dun, Matthew D., Mannan, Abdul, Rigby, Callum J., Butler, Stephen, Toop, Hamish D., Beck, Dominik, Connerty, Patrick, Sillar, Jonathan, Kahl, Richard G. S., Duchatel, Ryan J., Germon, Zacary, Faulkner, Sam, Chi, Mengna, Skerrett-Byrne, David, Murray, Heather C., Flanagan, Hayley, Almazi, Juhura G., Hondermarck, Hubert, Nixon, Brett, De Iuliis, Geoff, Chamberlain, Janis, Alvaro, Frank, de Bock, Charles E., Morris, Jonathan C., Enjeti, Anoop K., Verrills, Nicole M.
Publicado 2020

Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma

por Duchatel, Ryan J, Mannan, Abdul, Woldu, Ameha S, Hawtrey, Tom, Hindley, Phoebe A, Douglas, Alicia M, Jackson, Evangeline R, Findlay, Izac J, Germon, Zacary P, Staudt, Dilana, Kearney, Padraic S, Smith, Nathan D, Hindley, Kate E, Cain, Jason E, André, Nicolas, La Madrid, Andres Morales, Nixon, Brett, De Iuliis, Geoffry N, Nazarian, Javad, Irish, Kathleen, Alvaro, Frank, Eisenstat, David D, Beck, Alexander, Vitanza, Nicholas A, Mueller, Sabine, Morris, Jonathan C, Dun, Matthew D
Publicado 2021

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

por Tzelepis, Konstantinos, De Braekeleer, Etienne, Aspris, Demetrios, Barbieri, Isaia, Vijayabaskar, M. S., Liu, Wen-Hsin, Gozdecka, Malgorzata, Metzakopian, Emmanouil, Toop, Hamish D., Dudek, Monika, Robson, Samuel C., Hermida-Prado, Francisco, Yang, Yu Hsuen, Babaei-Jadidi, Roya, Garyfallos, Dimitrios A., Ponstingl, Hannes, Dias, Joao M. L., Gallipoli, Paolo, Seiler, Michael, Buonamici, Silvia, Vick, Binje, Bannister, Andrew J., Rad, Roland, Prinjha, Rab K., Marioni, John C., Huntly, Brian, Batson, Jennifer, Morris, Jonathan C., Pina, Cristina, Bradley, Allan, Jeremias, Irmela, Bates, David O., Yusa, Kosuke, Kouzarides, Tony, Vassiliou, George S.
Publicado 2018