Clinical Trial Highlights: Modulators of Mitochondrial Function

por Capriglia, Francesco, Burgess, Toby, Bandmann, Oliver, Mortiboys, Heather
Publicado 2023

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

por Tain, Luke S, Mortiboys, Heather, Tao, Ran N, Ziviani, Elena, Bandmann, Oliver, Whitworth, Alexander J
Publicado 2009

Peripheral Glycolysis in Neurodegenerative Diseases

por Bell, Simon M., Burgess, Toby, Lee, James, Blackburn, Daniel J., Allen, Scott P., Mortiboys, Heather
Publicado 2020

The Complex I Subunit NDUFA10 Selectively Rescues Drosophila pink1 Mutants through a Mechanism Independent of Mitophagy

por Pogson, Joe H., Ivatt, Rachael M., Sanchez-Martinez, Alvaro, Tufi, Roberta, Wilson, Emma, Mortiboys, Heather, Whitworth, Alexander J.
Publicado 2014

A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo

por Morsli, Samir, Henriques, Catarina M., Ellis, Pamela S., Mortiboys, Heather, Baxendale, Sarah, Loynes, Catherine A., Renshaw, Stephen A., Bellantuono, Ilaria
Publicado 2023

Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy

por Rusilowicz-Jones, Emma V, Barone, Francesco G, Lopes, Fernanda Martins, Stephen, Elezabeth, Mortiboys, Heather, Urbé, Sylvie, Clague, Michael J
Publicado 2021

FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels

por Elcocks, Hannah, Brazel, Ailbhe J, McCarron, Katy R, Kaulich, Manuel, Husnjak, Koraljka, Mortiboys, Heather, Clague, Michael J, Urbé, Sylvie
Publicado 2023

Deficits in Mitochondrial Spare Respiratory Capacity Contribute to the Neuropsychological Changes of Alzheimer’s Disease

por Bell, Simon M., De Marco, Matteo, Barnes, Katy, Shaw, Pamela J., Ferraiuolo, Laura, Blackburn, Daniel J., Mortiboys, Heather, Venneri, Annalena
Publicado 2020

Mitochondrial Dysfunction in Alzheimer’s Disease: A Biomarker of the Future?

por Bell, Simon M., Barnes, Katy, De Marco, Matteo, Shaw, Pamela J., Ferraiuolo, Laura, Blackburn, Daniel J., Venneri, Annalena, Mortiboys, Heather
Publicado 2021

Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1 (−/−) zebrafish

por Soman, Smijin, Keatinge, Marcus, Moein, Mahsa, Da Costa, Marc, Mortiboys, Heather, Skupin, Alexander, Sugunan, Sreedevi, Bazala, Michal, Kuznicki, Jacek, Bandmann, Oliver
Publicado 2016

Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons

por Schwartzentruber, Aurelie, Boschian, Camilla, Lopes, Fernanda Martins, Myszczynska, Monika A., New, Elizabeth J., Beyrath, Julien, Smeitink, Jan, Ferraiuolo, Laura, Mortiboys, Heather
Publicado 2020

The Effect of SOD1 Mutation on Cellular Bioenergetic Profile and Viability in Response to Oxidative Stress and Influence of Mutation-Type

por Richardson, Katie, Allen, Scott P., Mortiboys, Heather, Grierson, Andrew J., Wharton, Stephen B., Ince, Paul G., Shaw, Pamela J., Heath, Paul R.
Publicado 2013

3α,7-Dihydroxy-14(13→12)abeo-5β,12α(H),13β(H)-cholan-24-oic Acids Display Neuroprotective Properties in Common Forms of Parkinson’s Disease

por Luxenburger, Andreas, Clemmens, Hannah, Hastings, Christopher, Harris, Lawrence D., Ure, Elizabeth M., Cameron, Scott A., Aasly, Jan, Bandmann, Oliver, Weymouth-Wilson, Alex, Furneaux, Richard H., Mortiboys, Heather
Publicado 2022

Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease

por Bell, Simon M., Barnes, Katy, Clemmens, Hannah, Al-Rafiah, Aziza R., Al-ofi, Ebtisam A., Leech, Vicki, Bandmann, Oliver, Shaw, Pamela J., Blackburn, Daniel J., Ferraiuolo, Laura, Mortiboys, Heather
Publicado 2018

Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons

por Ratcliffe, Laura E., Vázquez Villaseñor, Irina, Jennings, Luke, Heath, Paul R., Mortiboys, Heather, Schwartzentruber, Aurelie, Karyka, Evangelia, Simpson, Julie E., Ince, Paul G., Garwood, Claire J., Wharton, Stephen B.
Publicado 2018

Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency

por Keatinge, Marcus, Gegg, Matthew E., Watson, Lisa, Mortiboys, Heather, Li, Nan, Dunning, Mark, Ailani, Deepak, Bui, Hai, van Rens, Astrid, Lefeber, Dirk J., Schapira, Anthony H. V., MacDonald, Ryan B., Bandmann, Oliver
Publicado 2023

The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity

por Frison, Michele, Faccenda, Danilo, Abeti, Rosella, Rigon, Manuel, Strobbe, Daniela, England-Rendon, Britannie S., Cash, Diana, Barnes, Katy, Sadeghian, Mona, Sajic, Marija, Wells, Lisa A., Xia, Dong, Giunti, Paola, Smith, Kenneth, Mortiboys, Heather, Turkheimer, Federico E., Campanella, Michelangelo
Publicado 2021

Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease

por Gatto, Noemi, Dos Santos Souza, Cleide, Shaw, Allan C., Bell, Simon M., Myszczynska, Monika A., Powers, Samantha, Meyer, Kathrin, Castelli, Lydia M., Karyka, Evangelia, Mortiboys, Heather, Azzouz, Mimoun, Hautbergue, Guillaume M., Márkus, Nóra M., Shaw, Pamela J., Ferraiuolo, Laura
Publicado 2020

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

por Mihaylov, Simeon R., Castelli, Lydia M., Lin, Ya-Hui, Gül, Aytac, Soni, Nikita, Hastings, Christopher, Flynn, Helen R., Păun, Oana, Dickman, Mark J., Snijders, Ambrosius P., Goldstone, Robert, Bandmann, Oliver, Shelkovnikova, Tatyana A., Mortiboys, Heather, Ultanir, Sila K., Hautbergue, Guillaume M.
Publicado 2023

Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)

por Cox, Laura E., Ferraiuolo, Laura, Goodall, Emily F., Heath, Paul R., Higginbottom, Adrian, Mortiboys, Heather, Hollinger, Hannah C., Hartley, Judith A., Brockington, Alice, Burness, Christine E., Morrison, Karen E., Wharton, Stephen B., Grierson, Andrew J., Ince, Paul G., Kirby, Janine, Shaw, Pamela J.
Publicado 2010