The biological function of an insect antifreeze protein simulated by molecular dynamics

por Kuiper, Michael J, Morton, Craig J, Abraham, Sneha E, Gray-Weale, Angus
Publicado 2015

An Intermolecular π-Stacking Interaction Drives Conformational Changes Necessary to β-Barrel Formation in a Pore-Forming Toxin

por Burns, Joshua R., Morton, Craig J., Parker, Michael W., Tweten, Rodney K.
Publicado 2019

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA

por Ascher, David B., Wielens, Jerome, Nero, Tracy L., Doughty, Larissa, Morton, Craig J., Parker, Michael W.
Publicado 2014

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

por McMahon, Roisin M., Coinçon, Mathieu, Tay, Stephanie, Heras, Begoña, Morton, Craig J., Scanlon, Martin J., Martin, Jennifer L.
Publicado 2015

A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins

por Evans, Jordan C., Johnstone, Bronte A., Lawrence, Sara L., Morton, Craig J., Christie, Michelle P., Parker, Michael W., Tweten, Rodney K.
Publicado 2020

Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

por Conway, Ashlee J., Brown, Fiona C., Hortle, Elinor J., Burgio, Gaetan, Foote, Simon J., Morton, Craig J., Jane, Stephen M., Curtis, David J.
Publicado 2018

Single-molecule analysis of the entire perfringolysin O pore formation pathway

por McGuinness, Conall, Walsh, James C, Bayly-Jones, Charles, Dunstone, Michelle A, Christie, Michelle P, Morton, Craig J, Parker, Michael W, Böcking, Till
Publicado 2022

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

por Lawrence, Sara L., Feil, Susanne C., Morton, Craig J., Farrand, Allison J., Mulhern, Terrence D., Gorman, Michael A., Wade, Kristin R., Tweten, Rodney K., Parker, Michael W.
Publicado 2015

C-reactive protein, immunothrombosis and venous thromboembolism

por Dix, Caroline, Zeller, Johannes, Stevens, Hannah, Eisenhardt, Steffen U., Shing, Karen S. Cheung Tung, Nero, Tracy L., Morton, Craig J., Parker, Michael W., Peter, Karlheinz, McFadyen, James D.
Publicado 2022

Copper binding to the Alzheimer’s disease amyloid precursor protein

por Kong, Geoffrey K.-W., Miles, Luke A., Crespi, Gabriela A. N., Morton, Craig J., Ng, Hooi Ling, Barnham, Kevin J., McKinstry, William J., Cappai, Roberto, Parker, Michael W.
Publicado 2007

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

por Mohanty, Biswaranjan, Rimmer, Kieran, McMahon, Róisín M., Headey, Stephen J., Vazirani, Mansha, Shouldice, Stephen R., Coinçon, Mathieu, Tay, Stephanie, Morton, Craig J., Simpson, Jamie S., Martin, Jennifer L., Scanlon, Martin J.
Publicado 2017

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

por Wade, Kristin R., Lawrence, Sara L., Farrand, Allison J., Hotze, Eileen M., Kuiper, Michael J., Gorman, Michael A., Christie, Michelle P., Panjikar, Santosh, Morton, Craig J., Parker, Michael W., Tweten, Rodney K.
Publicado 2019

Heparin Inhibits SARS-CoV-2 Replication in Human Nasal Epithelial Cells

por Lee, Leo Yi Yang, Suryadinata, Randy, McCafferty, Conor, Ignjatovic, Vera, Purcell, Damian F. J., Robinson, Phil, Morton, Craig J., Parker, Michael W., Anderson, Gary P., Monagle, Paul, Subbarao, Kanta, Neil, Jessica A.
Publicado 2022

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

por De Luca, Anastasia, Parker, Lorien J., Ang, Wee Han, Rodolfo, Carlo, Gabbarini, Valentina, Hancock, Nancy C., Palone, Francesca, Mazzetti, Anna P., Menin, Laure, Morton, Craig J., Parker, Michael W., Lo Bello, Mario, Dyson, Paul J.
Publicado 2019

Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant

por Metcalfe, Riley D., Hanssen, Eric, Fung, Ka Yee, Aizel, Kaheina, Kosasih, Clara C., Zlatic, Courtney O., Doughty, Larissa, Morton, Craig J., Leis, Andrew P., Parker, Michael W., Gooley, Paul R., Putoczki, Tracy L., Griffin, Michael D. W.
Publicado 2023

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

por Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Kan, Winnie L., Barry, Emma F., Dottore, Mara, Cheung Tung Shing, Karen S., Morton, Craig J., Dhagat, Urmi, Hardy, Matthew P., Wilson, Nicholas J., Downton, Matthew T., Schieber, Christine, Hughes, Timothy P., Lopez, Angel F., Parker, Michael W.
Publicado 2018

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

por Braig, David, Nero, Tracy L., Koch, Hans-Georg, Kaiser, Benedict, Wang, Xiaowei, Thiele, Jan R., Morton, Craig J., Zeller, Johannes, Kiefer, Jurij, Potempa, Lawrence A., Mellett, Natalie A., Miles, Luke A., Du, Xiao-Jun, Meikle, Peter J., Huber-Lang, Markus, Stark, G. Björn, Parker, Michael W., Peter, Karlheinz, Eisenhardt, Steffen U.
Publicado 2017

A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein

por Zeller, Johannes, Cheung Tung Shing, Karen S, Nero, Tracy L, McFadyen, James D, Krippner, Guy, Bogner, Balázs, Kreuzaler, Sheena, Kiefer, Jurij, Horner, Verena K, Braig, David, Danish, Habiba, Baratchi, Sara, Fricke, Mark, Wang, Xiaowei, Kather, Michel G, Kammerer, Bernd, Woollard, Kevin J, Sharma, Prerna, Morton, Craig J, Pietersz, Geoffrey, Parker, Michael W, Peter, Karlheinz, Eisenhardt, Steffen U
Publicado 2022

Reaction hijacking of tyrosine tRNA synthetase as a whole-of-life-cycle antimalarial strategy

por Xie, Stanley C., Metcalfe, Riley D., Dunn, Elyse, Morton, Craig J., Huang, Shih-Chung, Puhalovich, Tanya, Du, Yawei, Wittlin, Sergio, Nie, Shuai, Luth, Madeline R., Ma, Liting, Kim, Mi-Sook, Pasaje, Charisse Flerida A., Kumpornsin, Krittikorn, Giannangelo, Carlo, Houghton, Fiona J., Churchyard, Alisje, Famodimu, Mufuliat T., Barry, Daniel C., Gillett, David L., Dey, Sumanta, Kosasih, Clara C., Newman, William, Niles, Jacquin C., Lee, Marcus C.S., Baum, Jake, Ottilie, Sabine, Winzeler, Elizabeth A., Creek, Darren J., Williamson, Nicholas, Parker, Michael W., Brand, Stephen L., Langston, Steven P., Dick, Lawrence R., Griffin, Michael D.W., Gould, Alexandra E., Tilley, Leann
Publicado 2022

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

por Xie, Stanley C., Metcalfe, Riley D., Mizutani, Hirotake, Puhalovich, Tanya, Hanssen, Eric, Morton, Craig J., Du, Yawei, Dogovski, Con, Huang, Shih-Chung, Ciavarri, Jeffrey, Hales, Paul, Griffin, Robert J., Cohen, Lawrence H., Chuang, Bei-Ching, Wittlin, Sergio, Deni, Ioanna, Yeo, Tomas, Ward, Kurt E., Barry, Daniel C., Liu, Boyin, Gillett, David L., Crespo-Fernandez, Benigno F., Ottilie, Sabine, Mittal, Nimisha, Churchyard, Alisje, Ferguson, Daniel, Aguiar, Anna Caroline C., Guido, Rafael V. C., Baum, Jake, Hanson, Kirsten K., Winzeler, Elizabeth A., Gamo, Francisco-Javier, Fidock, David A., Baud, Delphine, Parker, Michael W., Brand, Stephen, Dick, Lawrence R., Griffin, Michael D. W., Gould, Alexandra E., Tilley, Leann
Publicado 2021