Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury

por Gibson, Andrew, Hammond, Sean, Jaruthamsophon, Kanoot, Roth, Sharin, Mosedale, Merrie, Naisbitt, Dean J.
Publicado 2020

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis

por Norona, Leah M., Nguyen, Deborah G., Gerber, David A., Presnell, Sharon C., Mosedale, Merrie, Watkins, Paul B.
Publicado 2019

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

por Longo, Diane M, Woodhead, Jeffrey L, Walker, Paul, Herédi-Szabó, Krisztina, Mogyorósi, Károly, Wolenski, Francis S, Dragan, Yvonne P, Mosedale, Merrie, Siler, Scott Q, Watkins, Paul B, Howell, Brett A
Publicado 2019

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

por Woodhead, Jeffrey L., Brock, William J., Roth, Sharin E., Shoaf, Susan E., Brouwer, Kim L.R., Church, Rachel, Grammatopoulos, Tom N., Stiles, Linsey, Siler, Scott Q., Howell, Brett A., Mosedale, Merrie, Watkins, Paul B., Shoda, Lisl K.M.
Publicado 2017