Sars-Cov-2 Infection Promotes Endothelial Dysfunction and Thrombosis in a Mouse Model of COVID-19

por Aiolfi, Roberto, Ahmed, Jeanine, de la Torre, Juan Carlos, Griffin, John H., Mosnier, Laurent O.
Publicado 2021

An engineered activated factor V for the prevention and treatment of acute traumatic coagulopathy and bleeding in mice

por Joseph, Bilgimol Chumappumkal, Miyazawa, Byron Y., Esmon, Charles T., Cohen, Mitchell J., von Drygalski, Annette, Mosnier, Laurent O.
Publicado 2022

An Engineered Factor Va Prevents Bleeding Induced by Anticoagulant wt Activated Protein C

por von Drygalski, Annette, Bhat, Vikas, Gale, Andrew J., Burnier, Laurent, Cramer, Thomas J., Griffin, John H., Mosnier, Laurent O.
Publicado 2014

Sex-Specific Differences in the Pathogenesis, Endothelial Dysfunction, and Hypercoagulability of Sars-Cov-2 Infection in K18-hACE2 Mice

por Aiolfi, Roberto, Deguchi, Hiroshi, Fernández, Jose F., Ahmed, Jeanine, Hauer-Jensen, Miriam, de la Torre, Juan Carlos, Mosnier, Laurent O.
Publicado 2022

Selective modulation of activated protein C activities by a nonactive site–targeting nanobody library

por Sim, Derek S., Shukla, Meenal, Mallari, Cornell R., Fernández, José A., Xu, Xiao, Schneider, Doug, Bauzon, Maxine, Hermiston, Terry W., Mosnier, Laurent O.
Publicado 2023

Endotoxemia and sepsis mortality reduction by non-anticoagulant–activated protein C

por Kerschen, Edward J., Fernandez, José A., Cooley, Brian C., Yang, Xia V., Sood, Rashmi, Mosnier, Laurent O., Castellino, Francis J., Mackman, Nigel, Griffin, John H., Weiler, Hartmut
Publicado 2007

Understanding COVID-19-associated coagulopathy

por Conway, Edward M., Mackman, Nigel, Warren, Ronald Q., Wolberg, Alisa S., Mosnier, Laurent O., Campbell, Robert A., Gralinski, Lisa E., Rondina, Matthew T., van de Veerdonk, Frank L., Hoffmeister, Karin M., Griffin, John H., Nugent, Diane, Moon, Kyung, Morrissey, James H.
Publicado 2022

Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis

por Williams, Darian, Mahmoud, Marwa, Liu, Renfa, Andueza, Aitor, Kumar, Sandeep, Kang, Dong-Won, Zhang, Jiahui, Tamargo, Ian, Villa-Roel, Nicolas, Baek, Kyung-In, Lee, Hwakyoung, An, Yongjin, Zhang, Leran, Tate, Edward W, Bagchi, Pritha, Pohl, Jan, Mosnier, Laurent O, Diamandis, Eleftherios P, Mihara, Koichiro, Hollenberg, Morley D, Dai, Zhifei, Jo, Hanjoong
Publicado 2022

Tumor-expressed factor VII is associated with survival and regulates tumor progression in breast cancer

por Kroone, Chantal, Tieken, Chris, Kocatürk, Begüm, Paauwe, Madelon, Blok, Erik J., Ünlü, Betül, van den Berg, Yascha W., Stanganello, Eliana, Kapteijn, Maaike Y., Swier, Nathalie, Zhang, Xi, Duits, Danique E. M., Lin, Yazhi, Oostenbrink, Lisa V. E., van den Akker, Rob F. P., Mosnier, Laurent O., Hawinkels, Lukas J., van Vlijmen, Bart J. M., Ruf, Wolfram, Kuppen, Peter J., Cannegieter, Suzanne C., Buijs, Jeroen T., Versteeg, Henri H.
Publicado 2023

Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia

por Zhao, Xiao-Yan, Wilmen, Andreas, Wang, Dongli, Wang, Xinquan, Bauzon, Maxine, Kim, Ji-Yun, Linden, Lars, Li, Liang, Egner, Ursula, Marquardt, Tobias, Moosmayer, Dieter, Tebbe, Jan, Glück, Julian Marius, Ellinger, Philipp, McLean, Kirk, Yuan, Shujun, Yegneswaran, Subramanian, Jiang, Xiaoqiao, Evans, Vince, Gu, Jian-Ming, Schneider, Doug, Zhu, Ying, Xu, Yifan, Mallari, Cornell, Hesslein, Ashley, Wang, Yan, Schmidt, Nicole, Gutberlet, Katrin, Ruehl-Fehlert, Christine, Freyberger, Alexius, Hermiston, Terry, Patel, Chandra, Sim, Derek, Mosnier, Laurent O., Laux, Volker
Publicado 2020