High-Throughput Phenotyping Toolkit for Characterizing Cellular Models of Hypertrophic Cardiomyopathy In Vitro

por Mosqueira, Diogo, Lis-Slimak, Katarzyna, Denning, Chris
Publicado 2019

Transfection of hPSC-Cardiomyocytes Using Viafect™ Transfection Reagent

por Bodbin, Sara E., Denning, Chris, Mosqueira, Diogo
Publicado 2020

Mitochondrial Medicine: Genetic Underpinnings and Disease Modeling Using Induced Pluripotent Stem Cell Technology

por Kargaran, Parisa K., Mosqueira, Diogo, Kozicz, Tamas
Publicado 2021

Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour

por Bhagwan, Jamie R., Collins, Emma, Mosqueira, Diogo, Bakar, Mine, Johnson, Benjamin B., Thompson, Alexander, Smith, James G.W., Denning, Chris
Publicado 2020

Mitochondrial DNA: Hotspot for Potential Gene Modifiers Regulating Hypertrophic Cardiomyopathy

por Kargaran, Parisa K., Evans, Jared M., Bodbin, Sara E., Smith, James G. W., Nelson, Timothy J., Denning, Chris, Mosqueira, Diogo
Publicado 2020

Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics

por Bhagwan, Jamie R., Mosqueira, Diogo, Chairez-Cantu, Karolina, Mannhardt, Ingra, Bodbin, Sara E., Bakar, Mine, Smith, James G.W., Denning, Chris
Publicado 2020

Simplified Footprint-Free Cas9/CRISPR Editing of Cardiac-Associated Genes in Human Pluripotent Stem Cells

por Kondrashov, Alexander, Hoang, Minh Duc, Smith, James G.W., Bhagwan, Jamie R., Duncan, Gary, Mosqueira, Diogo, Munoz, Maria Barbadillo, Vo, Nguyen T.N., Denning, Chris
Publicado 2018

Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits

por Smith, James G.W., Owen, Thomas, Bhagwan, Jamie R., Mosqueira, Diogo, Scott, Elizabeth, Mannhardt, Ingra, Patel, Asha, Barriales-Villa, Roberto, Monserrat, Lorenzo, Hansen, Arne, Eschenhagen, Thomas, Harding, Sian E., Marston, Steve, Denning, Chris
Publicado 2018

Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format

por Mannhardt, Ingra, Saleem, Umber, Mosqueira, Diogo, Loos, Malte F., Ulmer, Bärbel M., Lemoine, Marc D., Larsson, Camilla, Améen, Caroline, de Korte, Tessa, Vlaming, Maria L.H., Harris, Kate, Clements, Peter, Denning, Chris, Hansen, Arne, Eschenhagen, Thomas
Publicado 2020

An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility

por Madsen, Alexandra, Höppner, Grit, Krause, Julia, Hirt, Marc N., Laufer, Sandra D., Schweizer, Michaela, Tan, Wilson Lek Wen, Mosqueira, Diogo, Anene-Nzelu, Chukwuemeka George, Lim, Ives, Foo, Roger S.Y., Hansen, Arne, Eschenhagen, Thomas, Stenzig, Justus
Publicado 2020

Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform()

por Denning, Chris, Borgdorff, Viola, Crutchley, James, Firth, Karl S.A., George, Vinoj, Kalra, Spandan, Kondrashov, Alexander, Hoang, Minh Duc, Mosqueira, Diogo, Patel, Asha, Prodanov, Ljupcho, Rajamohan, Divya, Skarnes, William C., Smith, James G.W., Young, Lorraine E.
Publicado 2016

Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing

por Santos, Jorge M, Camões, Sérgio P, Filipe, Elysse, Cipriano, Madalena, Barcia, Rita N, Filipe, Mariana, Teixeira, Mariana, Simões, Sandra, Gaspar, Manuela, Mosqueira, Diogo, Nascimento, Diana S, Pinto-do-Ó, Perpétua, Cruz, Pedro, Cruz, Helder, Castro, Matilde, Miranda, Joana P
Publicado 2015

Human umbilical cord tissue-derived mesenchymal stromal cells attenuate remodeling after myocardial infarction by proangiogenic, antiapoptotic, and endogenous cell-activation mecha...

por Nascimento, Diana Santos, Mosqueira, Diogo, Sousa, Luís Moura, Teixeira, Mariana, Filipe, Mariana, Resende, Tatiana Pinho, Araújo, Ana Francisca, Valente, Mariana, Almeida, Joana, Martins, José Paulo, Santos, Jorge Miguel, Bárcia, Rita Nogueira, Cruz, Pedro, Cruz, Helder, Pinto-do-Ó, Perpétua
Publicado 2014

CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic...

por Mosqueira, Diogo, Mannhardt, Ingra, Bhagwan, Jamie R, Lis-Slimak, Katarzyna, Katili, Puspita, Scott, Elizabeth, Hassan, Mustafa, Prondzynski, Maksymilian, Harmer, Stephen C, Tinker, Andrew, Smith, James G W, Carrier, Lucie, Williams, Philip M, Gaffney, Daniel, Eschenhagen, Thomas, Hansen, Arne, Denning, Chris
Publicado 2018

ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes

por Zech, Antonia T. L., Prondzynski, Maksymilian, Singh, Sonia R., Pietsch, Niels, Orthey, Ellen, Alizoti, Erda, Busch, Josefine, Madsen, Alexandra, Behrens, Charlotta S., Meyer-Jens, Moritz, Mearini, Giulia, Lemoine, Marc D., Krämer, Elisabeth, Mosqueira, Diogo, Virdi, Sanamjeet, Indenbirken, Daniela, Depke, Maren, Salazar, Manuela Gesell, Völker, Uwe, Braren, Ingke, Pu, William T., Eschenhagen, Thomas, Hammer, Elke, Schlossarek, Saskia, Carrier, Lucie
Publicado 2022

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation

por Cuello, Friederike, Knaust, Anika E, Saleem, Umber, Loos, Malte, Raabe, Janice, Mosqueira, Diogo, Laufer, Sandra, Schweizer, Michaela, van der Kraak, Petra, Flenner, Frederik, Ulmer, Bärbel M, Braren, Ingke, Yin, Xiaoke, Theofilatos, Konstantinos, Ruiz‐Orera, Jorge, Patone, Giannino, Klampe, Birgit, Schulze, Thomas, Piasecki, Angelika, Pinto, Yigal, Vink, Aryan, Hübner, Norbert, Harding, Sian, Mayr, Manuel, Denning, Chris, Eschenhagen, Thomas, Hansen, Arne
Publicado 2021

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo

por Sala, Luca, van Meer, Berend J., Tertoolen, Leon G.J., Bakkers, Jeroen, Bellin, Milena, Davis, Richard P., Denning, Chris, Dieben, Michel A.E., Eschenhagen, Thomas, Giacomelli, Elisa, Grandela, Catarina, Hansen, Arne, Holman, Eduard R., Jongbloed, Monique R.M., Kamel, Sarah M., Koopman, Charlotte D., Lachaud, Quentin, Mannhardt, Ingra, Mol, Mervyn P.H., Mosqueira, Diogo, Orlova, Valeria V., Passier, Robert, Ribeiro, Marcelo C., Saleem, Umber, Smith, Godfrey L., Burton, Francis L., Mummery, Christine L.
Publicado 2018