Modeling buprenorphine reduction of fentanyl-induced respiratory depression

por Olofsen, Erik, Algera, Marijke Hyke, Moss, Laurence, Dobbins, Robert L., Groeneveld, Geert J., van Velzen, Monique, Niesters, Marieke, Dahan, Albert, Laffont, Celine M.
Publicado 2022

Tolerance to Opioid‐Induced Respiratory Depression in Chronic High‐Dose Opioid Users: A Model‐Based Comparison With Opioid‐Naïve Individuals

por Algera, Marijke Hyke, Olofsen, Erik, Moss, Laurence, Dobbins, Robert L., Niesters, Marieke, van Velzen, Monique, Groeneveld, Geert Jan, Heuberger, Jules, Laffont, Celine M., Dahan, Albert
Publicado 2020

First‐in‐human trial to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of STR‐324, a dual enkephalinase inhibitor for pain management

por Moss, Laurence M., Berends, Cecile L., van Brummelen, Emilie M. J., Kamerling, Ingrid M. C., Klaassen, Erica S., Bergmann, Kirsten, Ville, Vanessa, Juarez‐Perez, Victor, Benichou, Annie‐Claude, Groeneveld, Geert Jan
Publicado 2021

A Randomized Trial Assessing the Safety, Pharmacokinetics, and Efficacy During Morning Off of AZ‐009

por Thijssen, Eva, den Heijer, Jonas, Puibert, David, Moss, Laurence, Lei, Mingzu, Hasegawa, David, Keum, Kyo, Mochel, Ken, Ezzeldin Sharaf, Mohammed, Alfredson, Tom, Zeng, Wenxiang, van Brummelen, Emilie, Naranda, Tatjana, Groeneveld, Geert Jan
Publicado 2022

Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-toler...

por Moss, Laurence M., Algera, Marijke Hyke, Dobbins, Robert, Gray, Frank, Strafford, Stephanie, Heath, Amy, van Velzen, Monique, Heuberger, Jules A. A. C., Niesters, Marieke, Olofsen, Erik, Laffont, Celine M., Dahan, Albert, Groeneveld, Geert Jan
Publicado 2022