Fasting activates macroautophagy in neurons of Alzheimer’s disease mouse model but is insufficient to degrade amyloid-beta

por Chen, Xigui, Kondo, Kanoh, Motoki, Kazumi, Homma, Hidenori, Okazawa, Hitoshi
Publicado 2015

Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant

por Motoki, Kazumi, Kume, Hideaki, Oda, Akiko, Tamaoka, Akira, Hosaka, Ai, Kametani, Fuyuki, Araki, Wataru
Publicado 2012

LRP1 Downregulates the Alzheimer’s β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking1,2,3

por Tanokashira, Daisuke, Motoki, Kazumi, Minegishi, Seiji, Hosaka, Ai, Mamada, Naomi, Tamaoka, Akira, Okada, Takashi, Lakshmana, Madepalli K., Araki, Wataru
Publicado 2015

HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease

por Fujita, Kyota, Motoki, Kazumi, Tagawa, Kazuhiko, Chen, Xigui, Hama, Hiroshi, Nakajima, Kazuyuki, Homma, Hidenori, Tamura, Takuya, Watanabe, Hirohisa, Katsuno, Masahisa, Matsumi, Chiemi, Kajikawa, Masunori, Saito, Takashi, Saido, Takaomi, Sobue, Gen, Miyawaki, Atsushi, Okazawa, Hitoshi
Publicado 2016

Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries

por Imamura, Tomomi, Fujita, Kyota, Tagawa, Kazuhiko, Ikura, Teikichi, Chen, Xigui, Homma, Hidenori, Tamura, Takuya, Mao, Ying, Taniguchi, Juliana Bosso, Motoki, Kazumi, Nakabayashi, Makoto, Ito, Nobutoshi, Yamada, Kazunori, Tomii, Kentaro, Okano, Hideyuki, Kaye, Julia, Finkbeiner, Steven, Okazawa, Hitoshi
Publicado 2016