Room-Temperature, Copper-Free Sonogashira Reactions Facilitated by Air-Stable, Monoligated Precatalyst [DTBNpP] Pd(crotyl)Cl

por Pohida, Katherine, Maloney, David J., Mott, Bryan T., Rai, Ganesha
Publicado 2018

Discovery of Novel Liver-Stage Antimalarials through Quantum Similarity

por Sullivan, David J., Liu, Yi, Mott, Bryan T., Kaludov, Nikola, Martinov, Martin N.
Publicado 2015

An Artemisinin-Derived Dimer Has Highly Potent Anti-Cytomegalovirus (CMV) and Anti-Cancer Activities

por He, Ran, Mott, Bryan T., Rosenthal, Andrew S., Genna, Douglas T., Posner, Gary H., Arav-Boger, Ravit
Publicado 2011

Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine

por Woodard, Lauren E., Mott, Bryan T., Singhal, Vandana, Kumar, Nirbhay, Shapiro, Theresa A., Posner, Gary H.
Publicado 2009

Drug resistant integrase mutants cause aberrant HIV integrations

por Varadarajan, Janani, McWilliams, Mary Jane, Mott, Bryan T., Thomas, Craig J., Smith, Steven J., Hughes, Stephen H.
Publicado 2016

A Novel 2-Carbon-Linked Dimeric Artemisinin With Potent Antileukemic Activity and Favorable Pharmacology

por Kagan, Amanda B., Moses, Blake S., Mott, Bryan T., Rai, Ganesha, Anders, Nicole M., Rudek, Michelle A., Civin, Curt I.
Publicado 2022

Complementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain Inhibitors

por Ferreira, Rafaela S., Simeonov, Anton, Jadhav, Ajit, Eidam, Oliv, Mott, Bryan T., Keiser, Michael J., McKerrow, James H., Maloney, David J., Irwin, John J., Shoichet, Brian K.
Publicado 2010

EPCT-22 SAFETY AND EFFICACY OF INTRAVENTRICULAR IMMUNOVIROTHERAPY WITH ONCOLYTIC HSV-1 G207 FOR TREATMENT OF LEPTOMENINGEAL DISEASE

por Kang, Kyung-Don, Bernstock, Joshua, Mott, Bryan, Nan, Li, Li, Rong, Totsch, Stacie, Gary, Sam, Ghajar-Rahimi, Gelare, Etminan, Tina, Eisemann, Tanja, Wechsler-Reya, Robert, Beierle, Elizabeth, Gillespie, George, Markert, James, Friedman, Gregory
Publicado 2021

Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs

por Fox, Jennifer M., Moynihan, James R., Mott, Bryan T., Mazzone, Jennifer R., Anders, Nicole M., Brown, Patrick A., Rudek, Michelle A., Liu, Jun O., Arav-Boger, Ravit, Posner, Gary H., Civin, Curt I., Chen, Xiaochun
Publicado 2016

mQC: A Heuristic Quality-Control Metric for High-Throughput Drug Combination Screening

por Chen, Lu, Wilson, Kelli, Goldlust, Ian, Mott, Bryan T., Eastman, Richard, Davis, Mindy I., Zhang, Xiaohu, McKnight, Crystal, Klumpp-Thomas, Carleen, Shinn, Paul, Simmons, John, Gormally, Mike, Michael, Sam, Thomas, Craig J., Ferrer, Marc, Guha, Rajarshi
Publicado 2016

Targeting Oncometabolism to Maximize Immunotherapy in Malignant Brain Tumors

por Bernstock, Joshua D., Kang, Kyung-Don, Klinger, Neil V., Olsen, Hannah E., Gary, Sam, Totsch, Stacie K., Ghajar-Rahimi, Gelare, Segar, David, Thompson, Eric M., Darley-Usmar, Victor, Mott, Bryan T., Peruzzotti-Jametti, Luca, Friedman, Gregory K.
Publicado 2022

A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1

por Schiller, Rachel, Scozzafava, Giuseppe, Tumber, Anthony, Wickens, James R, Bush, Jacob T, Rai, Ganesha, Lejeune, Clarisse, Choi, Hwanho, Yeh, Tzu-Lan, Chan, Mun Chiang, Mott, Bryan T, McCullagh, James S O, Maloney, David J, Schofield, Christopher J, Kawamura, Akane
Publicado 2014

Inhibiting WNT Ligand Production for Improved Immune Recognition in the Ovarian Tumor Microenvironment

por Goldsberry, Whitney N., Meza-Perez, Selene, Londoño, Angelina I., Katre, Ashwini A., Mott, Bryan T., Roane, Brandon M., Goel, Nidhi, Wall, Jaclyn A., Cooper, Sara J., Norian, Lyse A., Randall, Troy D., Birrer, Michael J., Arend, Rebecca C.
Publicado 2020

Alpha globin gene copy number and hypertension risk among Black Americans

por Ruhl, A. Parker, Jeffries, Neal, Yang, Yu, Gutierrez, Orlando M., Muntner, Paul, Naik, Rakhi P., Pecker, Lydia H., Mott, Bryan T., Zakai, Neil A., Safford, Monika M., Lange, Leslie A., Winkler, Cheryl A., Irvin, Marguerite R., Cushman, Mary, Ackerman, Hans C.
Publicado 2022

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

por King, Oliver N. F., Li, Xuan Shirley, Sakurai, Masaaki, Kawamura, Akane, Rose, Nathan R., Ng, Stanley S., Quinn, Amy M., Rai, Ganesha, Mott, Bryan T., Beswick, Paul, Klose, Robert J., Oppermann, Udo, Jadhav, Ajit, Heightman, Tom D., Maloney, David J., Schofield, Christopher J., Simeonov, Anton
Publicado 2010

Alpha globin gene copy number and incident ischemic stroke risk among Black Americans

por Ruhl, A. Parker, Jeffries, Neal, Yang, Yu, Brooks, Steven D., Naik, Rakhi P., Pecker, Lydia H., Mott, Bryan T., Winkler, Cheryl A., Armstrong, Nicole D., Zakai, Neil A., Gutierrez, Orlando M., Judd, Suzanne E., Howard, Virginia J., Howard, George, Irvin, Marguerite R., Cushman, Mary, Ackerman, Hans C.
Publicado 2023

KDM5 histone demethylases repress immune response via suppression of STING

por Wu, Lizhen, Cao, Jian, Cai, Wesley L., Lang, Sabine M., Horton, John R., Jansen, Daniel J., Liu, Zongzhi Z., Chen, Jocelyn F., Zhang, Meiling, Mott, Bryan T., Pohida, Katherine, Rai, Ganesha, Kales, Stephen C., Henderson, Mark J., Hu, Xin, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Zhu, Shu, Iwasaki, Akiko, Hall, Matthew D., Cheng, Xiaodong, Shadel, Gerald S., Yan, Qin
Publicado 2018

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations

por Mott, Bryan T., Eastman, Richard T., Guha, Rajarshi, Sherlach, Katy S., Siriwardana, Amila, Shinn, Paul, McKnight, Crystal, Michael, Sam, Lacerda-Queiroz, Norinne, Patel, Paresma R., Khine, Pwint, Sun, Hongmao, Kasbekar, Monica, Aghdam, Nima, Fontaine, Shaun D., Liu, Dongbo, Mierzwa, Tim, Mathews-Griner, Lesley A., Ferrer, Marc, Renslo, Adam R., Inglese, James, Yuan, Jing, Roepe, Paul D., Su, Xin-zhuan, Thomas, Craig J.
Publicado 2015

Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites

por Dorjsuren, Dorjbal, Eastman, Richard T., Wicht, Kathryn J., Jansen, Daniel, Talley, Daniel C., Sigmon, Benjamin A., Zakharov, Alexey V., Roncal, Norma, Girvin, Andrew T., Antonova-Koch, Yevgeniya, Will, Paul M., Shah, Pranav, Sun, Hongmao, Klumpp-Thomas, Carleen, Mok, Sachel, Yeo, Tomas, Meister, Stephan, Marugan, Juan Jose, Ross, Leila S., Xu, Xin, Maloney, David J., Jadhav, Ajit, Mott, Bryan T., Sciotti, Richard J., Winzeler, Elizabeth A., Waters, Norman C., Campbell, Robert F., Huang, Wenwei, Simeonov, Anton, Fidock, David A.
Publicado 2021

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

por Oshima, Nobu, Ishida, Ryo, Kishimoto, Shun, Beebe, Kristin, Brender, Jeffrey R., Yamamoto, Kazutoshi, Urban, Daniel, Rai, Ganesha, Johnson, Michelle S., Benavides, Gloria, Squadrito, Giuseppe L., Crooks, Dan, Jackson, Joseph, Joshi, Abhinav, Mott, Bryan T., Shrimp, Jonathan H., Moses, Michael A., Lee, Min-Jung, Yuno, Akira, Lee, Tobie D., Hu, Xin, Anderson, Tamara, Kusewitt, Donna, Hathaway, Helen H., Jadhav, Ajit, Picard, Didier, Trepel, Jane B., Mitchell, James B., Stott, Gordon M., Moore, William, Simeonov, Anton, Sklar, Larry A., Norenberg, Jeffrey P., Linehan, W. Marston, Maloney, David J., Dang, Chi V., Waterson, Alex G., Hall, Matthew, Darley-Usmar, Victor M., Krishna, Murali C., Neckers, Leonard M.
Publicado 2020