Membrane Association Allosterically Regulates Phospholipase A(2) Enzymes and Their Specificity

por Mouchlis, Varnavas D., Dennis, Edward A.
Publicado 2022

Substrate-Specific Inhibition Constants for Phospholipase A(2) Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics

por Mouchlis, Varnavas D., Armando, Aaron, Dennis, Edward A.
Publicado 2019

Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase A(2)s

por Hayashi, Daiki, Mouchlis, Varnavas D., Dennis, Edward A.
Publicado 2021

Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer’s Therapeutics

por Mouchlis, Varnavas D., Melagraki, Georgia, Zacharia, Lefteris C., Afantitis, Antreas
Publicado 2020

Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity

por Mouchlis, Varnavas D., Chen, Yuan, McCammon, J. Andrew, Dennis, Edward A.
Publicado 2018

Insertion of the Ca(2+)-Independent Phospholipase A(2) into a Phospholipid Bilayer via Coarse-Grained and Atomistic Molecular Dynamics Simulations

por Bucher, Denis, Hsu, Yuan-Hao, Mouchlis, Varnavas D., Dennis, Edward A., McCammon, J. Andrew
Publicado 2013

Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A(2) (GIVA cPLA(2))

por Psarra, Anastasia, Kokotou, Maroula G., Galiatsatou, Gerasimia, Mouchlis, Varnavas D., Dennis, Edward A., Kokotos, George
Publicado 2018

Correction to “Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A(2) (GIVA cPLA(2))”

por Psarra, Anastasia, Kokotou, Maroula G., Galiatsatou, Gerasimia, Mouchlis, Varnavas D., Dennis, Edward A., Kokotos, George
Publicado 2019

2-Oxoester Phospholipase A(2) Inhibitors with Enhanced Metabolic Stability

por Koutoulogenis, Giorgos S., Kokotou, Maroula G., Hayashi, Daiki, Mouchlis, Varnavas D., Dennis, Edward A., Kokotos, George
Publicado 2020

Lipoprotein-associated phospholipase A(2): A paradigm for allosteric regulation by membranes

por Mouchlis, Varnavas D., Hayashi, Daiki, Vasquez, Alexis M., Cao, Jian, McCammon, J. Andrew, Dennis, Edward A.
Publicado 2022

Advances in De Novo Drug Design: From Conventional to Machine Learning Methods

por Mouchlis, Varnavas D., Afantitis, Antreas, Serra, Angela, Fratello, Michele, Papadiamantis, Anastasios G., Aidinis, Vassilis, Lynch, Iseult, Greco, Dario, Melagraki, Georgia
Publicado 2021

2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A(2)

por Kokotou, Maroula G., Galiatsatou, Gerasimia, Magrioti, Victoria, Koutoulogenis, Giorgos, Barbayianni, Efrosini, Limnios, Dimitris, Mouchlis, Varnavas D., Satpathy, Banita, Navratil, Aaron, Dennis, Edward A., Kokotos, George
Publicado 2017