Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice

por Cao, Limin, Han, Gang, Lin, Caorui, Gu, Ben, Gao, Xianjun, Moulton, Hong M, Seow, Yiqi, Yin, HaiFang
Publicado 2016

Hexose Potentiates Peptide-Conjugated Morpholino Oligomer Efficacy in Cardiac Muscles of Dystrophic Mice in an Age-Dependent Manner

por Han, Gang, Gu, Ben, Lin, Caorui, Ning, Hanhan, Song, Jun, Gao, Xianjun, Moulton, Hong M., Yin, HaiFang
Publicado 2019

Fructose Promotes Uptake and Activity of Oligonucleotides with Different Chemistries in a Context-Dependent Manner in mdx Mice

por Cao, Limin, Han, Gang, Lin, Caorui, Gu, Ben, Gao, Xianjun, Moulton, Hong M., Seow, Yiqi, Yin, HaiFang
Publicado 2020

Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity

por Wu, Rebecca P., Youngblood, Derek S., Hassinger, Jed N., Lovejoy, Candace E., Nelson, Michelle H., Iversen, Patrick L., Moulton, Hong M.
Publicado 2007

Effective Dystrophin Restoration by a Novel Muscle-Homing Peptide-Morpholino Conjugate in Dystrophin-Deficient mdx Mice

por Gao, Xianjun, Zhao, Jingwen, Han, Gang, Zhang, Yajie, Dong, Xue, Cao, Limin, Wang, Qingsong, Moulton, Hong M., Yin, HaiFang
Publicado 2020

MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice

por Ran, Ning, Lin, Caorui, Leng, Ling, Han, Gang, Geng, Mengyuan, Wu, Yingjie, Bittner, Scott, Moulton, Hong M, Yin, HaiFang
Publicado 2020

Inhibition and Escape of SARS-CoV Treated with Antisense Morpholino Oligomers

por Neuman, Benjamin W., Stein, David A., Kroeker, Andrew D., Bestwick, Richard K., Iversen, Patrick L., Moulton, Hong M., Buchmeier, Michael J.
Publicado 2006

Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers

por Zhang, Yan-Jin, Wang, Kai-Yu, Stein, David A., Patel, Deendayal, Watkins, Rheba, Moulton, Hong M., Iversen, Patrick L., Matson, David O.
Publicado 2007

Cell-penetrating peptide-conjugated Morpholino rescues SMA in a symptomatic preclinical model

por Bersani, Margherita, Rizzuti, Mafalda, Pagliari, Elisa, Garbellini, Manuela, Saccomanno, Domenica, Moulton, Hong M., Bresolin, Nereo, Comi, Giacomo P., Corti, Stefania, Nizzardo, Monica
Publicado 2022

Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

por Yin, HaiFang, Boisguerin, Prisca, Moulton, Hong M, Betts, Corinne, Seow, Yiqi, Boutilier, Jordan, Wang, Qingsong, Walsh, Anthony, Lebleu, Bernard, Wood, Matthew JA
Publicado 2013

Functional Rescue of Dystrophin-Deficient mdx Mice by a Chimeric Peptide-PMO

por Yin, HaiFang, Moulton, Hong M., Betts, Corinne, Merritt, Thomas, Seow, Yiqi, Ashraf, Shirin, Wang, QingSong, Boutilier, Jordan, Wood, Matthew J.A.
Publicado 2020

Cell penetrating peptide conjugates of steric block oligonucleotides()

por Lebleu, Bernard, Moulton, Hong M., Abes, Rachida, Ivanova, Gabriela D., Abes, Said, Stein, David A., Iversen, Patrick L., Arzumanov, Andrey A., Gait, Michael J.
Publicado 2008

Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

por Yin, HaiFang, Boisguerin, Prisca, Moulton, Hong M., Betts, Corinne, Seow, Yiqi, Boutilier, Jordan, Wang, Qingsong, Walsh, Anthony, Lebleu, Bernard, Wood, Matthew J.A.
Publicado 2020

DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via a subcutaneous administration

por Aslesh, Tejal, Erkut, Esra, Ren, Jun, Lim, Kenji Rowel Q., Woo, Stanley, Hatlevig, Susan, Moulton, Hong M., Gosgnach, Simon, Greer, John, Maruyama, Rika, Yokota, Toshifumi
Publicado 2023

Delivery of steric block morpholino oligomers by (R-X-R)(4) peptides: structure–activity studies

por Abes, Rachida, Moulton, Hong M., Clair, Philippe, Yang, Sung-Tae, Abes, Said, Melikov, Kamran, Prevot, Paul, Youngblood, Derek S., Iversen, Patrick L., Chernomordik, Leonid V., Lebleu, Bernard
Publicado 2008

A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping

por Echigoya, Yusuke, Trieu, Nhu, Duddy, William, Moulton, Hong M., Yin, HaiFang, Partridge, Terence A., Hoffman, Eric P., Kornegay, Joe N., Rohret, Frank A., Rogers, Christopher S., Yokota, Toshifumi
Publicado 2021

Development of DG9 peptide-conjugated single- and multi-exon skipping therapies for the treatment of Duchenne muscular dystrophy

por Lim, Kenji Rowel Q., Woo, Stanley, Melo, Dyanna, Huang, Yiqing, Dzierlega, Kasia, Shah, Md Nur Ahad, Aslesh, Tejal, Roshmi, Rohini Roy, Echigoya, Yusuke, Maruyama, Rika, Moulton, Hong M., Yokota, Toshifumi
Publicado 2022

Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung

por Dang, Yan, van Heusden, Catharina, Nickerson, Veronica, Chung, Felicity, Wang, Yang, Quinney, Nancy L, Gentzsch, Martina, Randell, Scott H, Moulton, Hong M, Kole, Ryszard, Ni, Aiguo, Juliano, Rudolph L, Kreda, Silvia M
Publicado 2021

The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response

por Seifert, Leon Louis, Si, Clara, Saha, Debjani, Sadic, Mohammad, de Vries, Maren, Ballentine, Sarah, Briley, Aaron, Wang, Guojun, Valero-Jimenez, Ana M., Mohamed, Adil, Schaefer, Uwe, Moulton, Hong M., García-Sastre, Adolfo, Tripathi, Shashank, Rosenberg, Brad R., Dittmann, Meike
Publicado 2019

The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity

por Hage, Adam, Bharaj, Preeti, van Tol, Sarah, Giraldo, Maria I., Gonzalez-Orozco, Maria, Valerdi, Karl M., Warren, Abbey N., Aguilera-Aguirre, Leopoldo, Xie, Xuping, Widen, Steven G., Moulton, Hong M., Lee, Benhur, Johnson, Jeffrey R., Krogan, Nevan J., García-Sastre, Adolfo, Shi, Pei-Yong, Freiberg, Alexander N., Rajsbaum, Ricardo
Publicado 2022