Histone Deacetylase Inhibition Decreases Cholesterol Levels in Neuronal Cells by Modulating Key Genes in Cholesterol Synthesis, Uptake and Efflux

por Nunes, Maria João, Moutinho, Miguel, Gama, Maria João, Rodrigues, Cecília M. P., Rodrigues, Elsa
Publicado 2013

Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining

por Palmela, Inês, Sasaki, Hiroyuki, Cardoso, Filipa L., Moutinho, Miguel, Kim, Kwang S., Brites, Dora, Brito, Maria A.
Publicado 2012

Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk

por Moutinho, Miguel, Nunes, Maria João, Correia, Jorge C., Gama, Maria João, Castro-Caldas, Margarida, Cedazo-Minguez, Angel, Rodrigues, Cecília M. P., Björkhem, Ingemar, Ruas, Jorge L, Rodrigues, Elsa
Publicado 2016

PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease

por Tsai, Andy P., Dong, Chuanpeng, Lin, Peter Bor-Chian, Messenger, Evan J., Casali, Brad T., Moutinho, Miguel, Liu, Yunlong, Oblak, Adrian L., Lamb, Bruce T., Landreth, Gary E., Bissel, Stephanie J., Nho, Kwangsik
Publicado 2022

CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease

por Puntambekar, Shweta S., Moutinho, Miguel, Lin, Peter Bor-Chian, Jadhav, Vaishnavi, Tumbleson-Brink, Danika, Balaji, Ananya, Benito, Martin Alvarado, Xu, Guixiang, Oblak, Adrian, Lasagna-Reeves, Cristian A., Landreth, Gary E., Lamb, Bruce T.
Publicado 2022

Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice

por Jadhav, Vaishnavi S., Lin, Peter B. C., Pennington, Taylor, Di Prisco, Gonzalo Viana, Jannu, Asha Jacob, Xu, Guixiang, Moutinho, Miguel, Zhang, Jie, Atwood, Brady K., Puntambekar, Shweta S., Bissel, Stephanie J., Oblak, Adrian L., Landreth, Gary E., Lamb, Bruce T.
Publicado 2020

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

por Cheng-Hathaway, Paul J., Reed-Geaghan, Erin G., Jay, Taylor R., Casali, Brad T., Bemiller, Shane M., Puntambekar, Shweta S., von Saucken, Victoria E., Williams, Roxanne Y., Karlo, J. Colleen, Moutinho, Miguel, Xu, Guixiang, Ransohoff, Richard M., Lamb, Bruce T., Landreth, Gary E.
Publicado 2018

TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation

por Moutinho, Miguel, Coronel, Israel, Tsai, Andy P., Di Prisco, Gonzalo Viana, Pennington, Taylor, Atwood, Brady K., Puntambekar, Shweta S., Smith, Daniel C., Martinez, Pablo, Han, Seonggyun, Lee, Younghee, Lasagna-Reeves, Cristian A., Lamb, Bruce T., Bissel, Stephanie J., Nho, Kwangsik, Landreth, Gary E.
Publicado 2023