Treatment options for second-stage gambiense human African trypanosomiasis

por Eperon, Gilles, Balasegaram, Manica, Potet, Julien, Mowbray, Charles, Valverde, Olaf, Chappuis, François
Publicado 2014

Film-Forming Systems for the Delivery of DNDI-0690 to Treat Cutaneous Leishmaniasis

por Van Bocxlaer, Katrien, McArthur, Kerri-Nicola, Harris, Andy, Alavijeh, Mo, Braillard, Stéphanie, Mowbray, Charles E., Croft, Simon L.
Publicado 2021

Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis

por Wijnant, Gert-Jan, Croft, Simon L., de la Flor, Raul, Alavijeh, Mo, Yardley, Vanessa, Braillard, Stéphanie, Mowbray, Charles, Van Bocxlaer, Katrien
Publicado 2019

Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis

por Caridha, Diana, Vesely, Brian, van Bocxlaer, Katrien, Arana, Byron, Mowbray, Charles E., Rafati, Sima, Uliana, Silvia, Reguera, Rosa, Kreishman-Deitrick, Mara, Sciotti, Richard, Buffet, Pierre, Croft, Simon L.
Publicado 2019

Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides

por Thompson, Andrew M., Marshall, Andrew J., Maes, Louis, Yarlett, Nigel, Bacchi, Cyrus J., Gaukel, Eric, Wring, Stephen A., Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Mowbray, Charles E., Denny, William A.
Publicado 2018

Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis

por Van Bocxlaer, Katrien, Caridha, Diana, Black, Chad, Vesely, Brian, Leed, Susan, Sciotti, Richard J., Wijnant, Gert-Jan, Yardley, Vanessa, Braillard, Stéphanie, Mowbray, Charles E., Ioset, Jean-Robert, Croft, Simon L.
Publicado 2019

Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series

por Van den Kerkhof, Magali, Leprohon, Philippe, Mabille, Dorien, Hendrickx, Sarah, Tulloch, Lindsay B., Wall, Richard J., Wyllie, Susan, Chatelain, Eric, Mowbray, Charles E., Braillard, Stéphanie, Ouellette, Marc, Maes, Louis, Caljon, Guy
Publicado 2021

Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents

por Koovits, Paul J., Dessoy, Marco A., Matheeussen, An, Maes, Louis, Caljon, Guy, Ferreira, Leonardo L. G., Chelucci, Rafael C., Michelan-Duarte, Simone, Andricopulo, Adriano D., Campbell, Simon, Kratz, Jadel M., Mowbray, Charles E., Dias, Luiz C.
Publicado 2020

The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

por Abdelnabi, Rana, Foo, Caroline S., Jochmans, Dirk, Vangeel, Laura, De Jonghe, Steven, Augustijns, Patrick, Mols, Raf, Weynand, Birgit, Wattanakul, Thanaporn, Hoglund, Richard M., Tarning, Joel, Mowbray, Charles E., Sjö, Peter, Escudié, Fanny, Scandale, Ivan, Chatelain, Eric, Neyts, Johan
Publicado 2022

The Pandemic Response Box—Accelerating Drug Discovery Efforts after Disease Outbreaks

por Samby, Kirandeep, Besson, Dominique, Dutta, Anirban, Patra, Buddhadev, Doy, Angelique, Glossop, Paul, Mills, James, Whitlock, Gavin, Hooft van Huijsduijnen, Rob, Monaco, Alessandra, Bilbe, Graeme, Mowbray, Charles, Perry, Benjamin, Adam, Anna, Wells, Timothy N. C., Willis, Paul A.
Publicado 2022

Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2

por Driouich, Jean-Sélim, Cochin, Maxime, Touret, Franck, Petit, Paul-Rémi, Gilles, Magali, Moureau, Grégory, Barthélémy, Karine, Laprie, Caroline, Wattanakul, Thanaporn, Chotsiri, Palang, Hoglund, Richard M., Tarning, Joel, Fraisse, Laurent, Sjö, Peter, Mowbray, Charles E., Escudié, Fanny, Scandale, Ivan, Chatelain, Eric, de Lamballerie, Xavier, Solas, Caroline, Nougairède, Antoine
Publicado 2022

Collaborative virtual screening to elaborate an imidazo[1,2-a]pyridine hit series for visceral leishmaniasis

por Akao, Yuichiro, Canan, Stacie, Cao, Yafeng, Condroski, Kevin, Engkvist, Ola, Itono, Sachiko, Kaki, Rina, Kimura, Chiaki, Kogej, Thierry, Nagaoka, Kazuya, Naito, Akira, Nakai, Hiromi, Pairaudeau, Garry, Radu, Constantin, Roberts, Ieuan, Shimada, Mitsuyuki, Shum, David, Watanabe, Nao-aki, Xie, Huanxu, Yonezawa, Shuji, Yoshida, Osamu, Yoshida, Ryu, Mowbray, Charles, Perry, Benjamin
Publicado 2021

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

por Mowbray, Charles E., Braillard, Stéphanie, Glossop, Paul A., Whitlock, Gavin A., Jacobs, Robert T., Speake, Jason, Pandi, Bharathi, Nare, Bakela, Maes, Louis, Yardley, Vanessa, Freund, Yvonne, Wall, Richard J., Carvalho, Sandra, Bello, Davide, Van den Kerkhof, Magali, Caljon, Guy, Gilbert, Ian H., Corpas-Lopez, Victoriano, Lukac, Iva, Patterson, Stephen, Zuccotto, Fabio, Wyllie, Susan
Publicado 2021

2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling

por Ferreira, Rafael Augusto Alves, Junior, Celso de Oliveira Rezende, Martinez, Pablo David Grigol, Koovits, Paul John, Soares, Bruna Miranda, Ferreira, Leonardo L. G., Michelan-Duarte, Simone, Chelucci, Rafael Consolin, Andricopulo, Adriano D., Galuppo, Mariana K., Uliana, Silvia R. B., Matheeussen, An, Caljon, Guy, Maes, Louis, Campbell, Simon, Kratz, Jadel M., Mowbray, Charles E., Dias, Luiz Carlos
Publicado 2021

Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection

por Tawaraishi, Taisuke, Ochida, Atsuko, Akao, Yuichiro, Itono, Sachiko, Kamaura, Masahiro, Akther, Thamina, Shimada, Mitsuyuki, Canan, Stacie, Chowdhury, Sanjoy, Cao, Yafeng, Condroski, Kevin, Engkvist, Ola, Francisco, Amanda, Ghosh, Sunil, Kaki, Rina, Kelly, John M., Kimura, Chiaki, Kogej, Thierry, Nagaoka, Kazuya, Naito, Akira, Pairaudeau, Garry, Radu, Constantin, Roberts, Ieuan, Shum, David, Watanabe, Nao-aki, Xie, Huanxu, Yonezawa, Shuji, Yoshida, Osamu, Yoshida, Ryu, Mowbray, Charles, Perry, Benjamin
Publicado 2023

Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19

por Assmus, Frauke, Driouich, Jean-Sélim, Abdelnabi, Rana, Vangeel, Laura, Touret, Franck, Adehin, Ayorinde, Chotsiri, Palang, Cochin, Maxime, Foo, Caroline S., Jochmans, Dirk, Kim, Seungtaek, Luciani, Léa, Moureau, Grégory, Park, Soonju, Pétit, Paul-Rémi, Shum, David, Wattanakul, Thanaporn, Weynand, Birgit, Fraisse, Laurent, Ioset, Jean-Robert, Mowbray, Charles E., Owen, Andrew, Hoglund, Richard M., Tarning, Joel, de Lamballerie, Xavier, Nougairède, Antoine, Neyts, Johan, Sjö, Peter, Escudié, Fanny, Scandale, Ivan, Chatelain, Eric
Publicado 2022