Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy

por Fu, Zhe, Mowday, Alexandra M., Smaill, Jeff B., Hermans, Ian F., Patterson, Adam V.
Publicado 2021

Use of a Luciferase-Expressing Orthotopic Rat Brain Tumor Model to Optimize a Targeted Irradiation Strategy for Efficacy Testing with Temozolomide

por Mowday, Alexandra M., Lieuwes, Natasja G., Biemans, Rianne, Marcus, Damiënne, Rezaeifar, Behzad, Reniers, Brigitte, Verhaegen, Frank, Theys, Jan, Dubois, Ludwig J.
Publicado 2020

Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia

por Guise, Christopher P., Mowday, Alexandra M., Ashoorzadeh, Amir, Yuan, Ran, Lin, Wan-Hua, Wu, Dong-Hai, Smaill, Jeff B., Patterson, Adam V., Ding, Ke
Publicado 2014

Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress

por Mowday, Alexandra M., Guise, Christopher P., Ackerley, David F., Minton, Nigel P., Lambin, Philippe, Dubois, Ludwig J., Theys, Jan, Smaill, Jeff B., Patterson, Adam V.
Publicado 2016

Pseudomonas aeruginosa NfsB and nitro-CBI-DEI – a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy

por Green, Laura K, Syddall, Sophie P, Carlin, Kendall M, Bell, Glenn D, Guise, Christopher P, Mowday, Alexandra M, Hay, Michael P, Smaill, Jeffrey B, Patterson, Adam V, Ackerley, David F
Publicado 2013

Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

por Ashoorzadeh, Amir, Mowday, Alexandra M., Guise, Christopher P., Silva, Shevan, Bull, Matthew R., Abbattista, Maria R., Copp, Janine N., Williams, Elsie M., Ackerley, David F., Patterson, Adam V., Smaill, Jeff B.
Publicado 2022

Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3

por Abbattista, Maria R., Ashoorzadeh, Amir, Guise, Christopher P., Mowday, Alexandra M., Mittra, Rituparna, Silva, Shevan, Hicks, Kevin O., Bull, Matthew R., Jackson-Patel, Victoria, Lin, Xiaojing, Prosser, Gareth A., Lambie, Neil K., Dachs, Gabi U., Ackerley, David F., Smaill, Jeff B., Patterson, Adam V.
Publicado 2021

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

por van der Wiel, Alexander M.A., Jackson-Patel, Victoria, Niemans, Raymon, Yaromina, Ala, Liu, Emily, Marcus, Damiënne, Mowday, Alexandra M., Lieuwes, Natasja G., Biemans, Rianne, Lin, Xiaojing, Fu, Zhe, Kumara, Sisira, Jochems, Arthur, Ashoorzadeh, Amir, Anderson, Robert F., Hicks, Kevin O., Bull, Matthew R., Abbattista, Maria R., Guise, Christopher P., Deschoemaeker, Sofie, Thiolloy, Sophie, Heyerick, Arne, Solivio, Morwena J., Balbo, Silvia, Smaill, Jeff B., Theys, Jan, Dubois, Ludwig J., Patterson, Adam V., Lambin, Philippe
Publicado 2021