The Anticancer Drug Ellipticine Activated with Cytochrome P450 Mediates DNA Damage Determining Its Pharmacological Efficiencies: Studies with Rats, Hepatic Cytochrome P450 Reductas...

por Stiborová, Marie, Černá, Věra, Moserová, Michaela, Mrízová, Iveta, Arlt, Volker M., Frei, Eva
Publicado 2014

Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine

por Mrízová, Iveta, Moserová, Michaela, Milichovský, Jan, Šulc, Miroslav, Kizek, René, Kubáčková, Kateřina, Arlt, Volker M., Stiborová, Marie
Publicado 2016

The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/−) and...

por Willis, Alexandra J., Indra, Radek, Wohak, Laura E., Sozeri, Osman, Feser, Kerstin, Mrizova, Iveta, Phillips, David H., Stiborova, Marie, Arlt, Volker M.
Publicado 2018

Application of hepatic cytochrome b(5)/P450 reductase null (HBRN) mice to study the role of cytochrome b(5) in the cytochrome P450-mediated bioactivation of the anticancer drug ell...

por Reed, Lindsay, Indra, Radek, Mrizova, Iveta, Moserova, Michaela, Schmeiser, Heinz H., Wolf, C. Roland, Henderson, Colin J., Stiborova, Marie, Phillips, David H., Arlt, Volker M.
Publicado 2019

Induced expression of microsomal cytochrome b(5) determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I)

por Stiborová, Marie, Moserová, Michaela, Mrízová, Iveta, Dračínská, Helena, Martínek, Václav, Indra, Radek, Frei, Eva, Adam, Vojtěch, Kizek, René, Schmeiser, Heinz H., Kubáčková, Kateřina, Arlt, Volker M.
Publicado 2016

Cytochrome b(5) impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b(5)/P450 reductase null (HBRN) mice

por Reed, Lindsay, Mrizova, Iveta, Barta, Frantisek, Indra, Radek, Moserova, Michaela, Kopka, Klaus, Schmeiser, Heinz H., Wolf, C. Roland, Henderson, Colin J., Stiborova, Marie, Phillips, David H., Arlt, Volker M.
Publicado 2018

Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene

por Arlt, Volker M., Krais, Annette M., Godschalk, Roger W., Riffo-Vasquez, Yanira, Mrizova, Iveta, Roufosse, Candice A., Corbin, Charmaine, Shi, Quan, Frei, Eva, Stiborova, Marie, van Schooten, Frederik-Jan, Phillips, David H., Spina, Domenico
Publicado 2015

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone

por Arlt, Volker M., Meinl, Walter, Florian, Simone, Nagy, Eszter, Barta, Frantisek, Thomann, Marlies, Mrizova, Iveta, Krais, Annette M., Liu, Maggie, Richards, Meirion, Mirza, Amin, Kopka, Klaus, Phillips, David H., Glatt, Hansruedi, Stiborova, Marie, Schmeiser, Heinz H.
Publicado 2016