HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies

por Tracey, Natasha, Creedon, Helen, Kemp, Alain J., Culley, Jayne, Muir, Morwenna, Klinowska, Teresa, Brunton, Valerie G.
Publicado 2019

Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models

por Webb, Emily R, Dodd, Georgia L, Noskova, Michaela, Bullock, Esme, Muir, Morwenna, Frame, Margaret C, Serrels, Alan, Brunton, Valerie G
Publicado 2023

Evaluation of the dual mTOR/PI3K inhibitors Gedatolisib (PF-05212384) and PF-04691502 against ovarian cancer xenograft models

por Langdon, Simon P., Kay, Charlene, Um, In Hwa, Dodds, Michael, Muir, Morwenna, Sellar, Grant, Kan, Julie, Gourley, Charlie, Harrison, David J.
Publicado 2019

Transcript and protein profiling identifies signaling, growth arrest, apoptosis, and NF-κB survival signatures following GNRH receptor activation

por Meyer, Colette, Sims, Andrew H, Morgan, Kevin, Harrison, Beth, Muir, Morwenna, Bai, Jianing, Faratian, Dana, Millar, Robert P, Langdon, Simon P
Publicado 2013

Diversity of Matriptase Expression Level and Function in Breast Cancer

por Welman, Arkadiusz, Sproul, Duncan, Mullen, Peter, Muir, Morwenna, Kinnaird, Andrew R., Harrison, David J., Faratian, Dana, Brunton, Valerie G., Frame, Margaret C.
Publicado 2012

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment

por Dawson, John C., Munro, Alison, Macleod, Kenneth, Muir, Morwenna, Timpson, Paul, Williams, Robert J., Frame, Margaret, Brunton, Valerie G., Carragher, Neil O.
Publicado 2021

Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer

por Creedon, Helen, Balderstone, Lucy A., Muir, Morwenna, Balla, Jozef, Gomez-Cuadrado, Laura, Tracey, Natasha, Loane, Joseph, Klinowska, Teresa, Muller, William J., Brunton, Valerie G.
Publicado 2016

Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer

por Taylor, Karen J, Sims, Andrew H, Liang, Liang, Faratian, Dana, Muir, Morwenna, Walker, Graeme, Kuske, Barbara, Dixon, J Michael, Cameron, David A, Harrison, David J, Langdon, Simon P
Publicado 2010

WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel

por Artibani, Mara, Sims, Andrew H., Slight, Joan, Aitken, Stuart, Thornburn, Anna, Muir, Morwenna, Brunton, Valerie G., Del-Pozo, Jorge, Morrison, Linda R., Katz, Elad, Hastie, Nicholas D., Hohenstein, Peter
Publicado 2017

Development of mouse models of angiosarcoma driven by p53

por Salter, Donald M., Griffin, Meredyth, Muir, Morwenna, Teo, Katy, Culley, Jayne, Smith, James R., Gomez-Cuadrado, Laura, Matchett, Kylie, Sims, Andrew H., Hayward, Larry, Henderson, Neil C., Brunton, Valerie G.
Publicado 2019

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence

por Fernández-Duran, Irene, Quintanilla, Andrea, Tarrats, Núria, Birch, Jodie, Hari, Priya, Millar, Fraser R., Lagnado, Anthony B., Smer-Barreto, Vanessa, Muir, Morwenna, Brunton, Valerie G., Passos, João F., Acosta, Juan Carlos
Publicado 2021

ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

por Bolado-Carrancio, Alfonso, Lee, Martin, Ewing, Ailith, Muir, Morwenna, Macleod, Kenneth G., Gallagher, William M., Nguyen, Lan K., Carragher, Neil O., Semple, Colin A., Brunton, Valerie G., Caswell, Patrick T., von Kriegsheim, Alex
Publicado 2021

Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors

por Beetham, Henry, Griffith, Billie G.C., Murina, Olga, Loftus, Alexander E.P., Parry, David A., Temps, Carolin, Culley, Jayne, Muir, Morwenna, Unciti-Broceta, Asier, Sims, Andrew H., Byron, Adam, Brunton, Valerie G.
Publicado 2022

11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis

por Davidson, Callam T., Miller, Eileen, Muir, Morwenna, Dawson, John C., Lee, Martin, Aitken, Stuart, Serrels, Alan, Webster, Scott P., Homer, Natalie Z. M., Andrew, Ruth, Brunton, Valerie G., Hadoke, Patrick W. F., Walker, Brian R.
Publicado 2023

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

por Hari, Priya, Millar, Fraser R., Tarrats, Nuria, Birch, Jodie, Quintanilla, Andrea, Rink, Curtis J., Fernández-Duran, Irene, Muir, Morwenna, Finch, Andrew J., Brunton, Valerie G., Passos, João F., Morton, Jennifer P., Boulter, Luke, Acosta, Juan Carlos
Publicado 2019

Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity...

por Fraser, Craig, Dawson, John C., Dowling, Reece, Houston, Douglas R., Weiss, Jason T., Munro, Alison F., Muir, Morwenna, Harrington, Lea, Webster, Scott P., Frame, Margaret C., Brunton, Valerie G., Patton, E. Elizabeth, Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2016

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

por Serrels, Alan, Lund, Tom, Serrels, Bryan, Byron, Adam, McPherson, Rhoanne C., von Kriegsheim, Alexander, Gómez-Cuadrado, Laura, Canel, Marta, Muir, Morwenna, Ring, Jennifer E., Maniati, Eleni, Sims, Andrew H., Pachter, Jonathan A., Brunton, Valerie G., Gilbert, Nick, Anderton, Stephen M., Nibbs, Robert J.B., Frame, Margaret C.
Publicado 2015

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

por Zimmermann, Michal, Murina, Olga, Reijns, Martin A. M., Agathanggelou, Angelo, Challis, Rachel, Tarnauskaitė, Žygimantė, Muir, Morwenna, Fluteau, Adeline, Aregger, Michael, McEwan, Andrea, Yuan, Wei, Clarke, Matthew, Lambros, Maryou B., Paneesha, Shankara, Moss, Paul, Chandrashekhar, Megha, Angers, Stephane, Moffat, Jason, Brunton, Valerie G., Hart, Traver, de Bono, Johann, Stankovic, Tatjana, Jackson, Andrew P., Durocher, Daniel
Publicado 2018

Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer

por Millar, Fraser R., Pennycuick, Adam, Muir, Morwenna, Quintanilla, Andrea, Hari, Priya, Freyer, Elisabeth, Gautier, Philippe, Meynert, Alison, Grimes, Graeme, Coll, Carla Salomo, Zdral, Sofia, Victorelli, Stella, Teixeira, Vitor H., Connelly, John, Passos, João F., Ros, Marian A., Wallace, William A.H., Frame, Margaret C., Sims, Andrew H., Boulter, Luke, Janes, Sam M., Wilkinson, Simon, Acosta, Juan Carlos
Publicado 2022

A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

por Temps, Carolin, Lietha, Daniel, Webb, Emily R., Li, Xue-Feng, Dawson, John C., Muir, Morwenna, Macleod, Kenneth G., Valero, Teresa, Munro, Alison F., Contreras-Montoya, Rafael, Luque-Ortega, Juan R., Fraser, Craig, Beetham, Henry, Schoenherr, Christina, Lopalco, Maria, Arends, Mark J., Frame, Margaret C., Qian, Bin-Zhi, Brunton, Valerie G., Carragher, Neil O., Unciti-Broceta, Asier
Publicado 2021