Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits

por Herranz-Martin, Saul, Chandran, Jayanth, Lewis, Katherine, Mulcahy, Padraig, Higginbottom, Adrian, Walker, Callum, Valenzuela, Isabel Martinez-Pena y, Jones, Ross A., Coldicott, Ian, Iannitti, Tommaso, Akaaboune, Mohammed, El-Khamisy, Sherif F., Gillingwater, Thomas H., Shaw, Pamela J., Azzouz, Mimoun
Publicado 2017

C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten

por Stopford, Matthew J., Higginbottom, Adrian, Hautbergue, Guillaume M., Cooper-Knock, Johnathan, Mulcahy, Padraig J., De Vos, Kurt J., Renton, Alan E., Pliner, Hannah, Calvo, Andrea, Chio, Adriano, Traynor, Bryan J., Azzouz, Mimoun, Heath, Paul R., Kirby, Janine, Shaw, Pamela J.
Publicado 2017

C9orf72 Expansion Disrupts ATM-mediated Chromosomal Break Repair

por Walker, Callum, Herranz-Martin, Saul, Karyka, Evangelia, Liao, Chunyan, Lewis, Katherine, Elsayed, Waheba, Lukashchuk, Vera, Chiang, Shih-Chieh, Ray, Swagat, Mulcahy, Padraig J., Jurga, Mateusz, Tsagakis, Ioannis, Iannitti, Tommaso, Chandran, Jayanth, Coldicott, Ian, De Vos, Kurt J., Hassan, Mohamed K., Higginbottom, Adrian, Shaw, Pamela J., Hautbergue, Guillaume M., Azzouz, Mimoun, El-Khamisy, Sherif F.
Publicado 2017