Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

por Pandyra, Aleksandra A., Mullen, Peter J., Goard, Carolyn A., Ericson, Elke, Sharma, Piyush, Kalkat, Manpreet, Yu, Rosemary, Pong, Janice T., Brown, Kevin R., Hart, Traver, Gebbia, Marinella, Lang, Karl S., Giaever, Guri, Nislow, Corey, Moffat, Jason, Penn, Linda Z.
Publicado 2015

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer

por Longo, Joseph, Mullen, Peter J., Yu, Rosemary, van Leeuwen, Jenna E., Masoomian, Mehdi, Woon, Dixon T.S., Wang, Yuzhuo, Chen, Eric X., Hamilton, Robert J., Sweet, Joan M., van der Kwast, Theodorus H., Fleshner, Neil E., Penn, Linda Z.
Publicado 2019

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

por Mullen, Peter J., Garcia, Gustavo, Purkayastha, Arunima, Matulionis, Nedas, Schmid, Ernst W., Momcilovic, Milica, Sen, Chandani, Langerman, Justin, Ramaiah, Arunachalam, Shackelford, David B., Damoiseaux, Robert, French, Samuel W., Plath, Kathrin, Gomperts, Brigitte N., Arumugaswami, Vaithilingaraja, Christofk, Heather R.
Publicado 2021

A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer

por Longo, Joseph, Hamilton, Robert J., Masoomian, Mehdi, Khurram, Najia, Branchard, Emily, Mullen, Peter J., Elbaz, Mohamad, Hersey, Karen, Chadwick, Dianne, Ghai, Sangeet, Andrews, David W., Chen, Eric X., van der Kwast, Theodorus H., Fleshner, Neil E., Penn, Linda Z.
Publicado 2020

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

por Halbrook, Christopher J., Thurston, Galloway, Boyer, Seth, Anaraki, Cecily, Jiménez, Jennifer A., McCarthy, Amy, Steele, Nina G., Kerk, Samuel A., Hong, Hanna S., Lin, Lin, Law, Fiona V., Felton, Catherine, Scipioni, Lorenzo, Sajjakulnukit, Peter, Andren, Anthony, Beutel, Alica K., Singh, Rima, Nelson, Barbara S., Van Den Bergh, Fran, Krall, Abigail S., Mullen, Peter J., Zhang, Li, Batra, Sandeep, Morton, Jennifer P., Stanger, Ben Z., Christofk, Heather R., Digman, Michelle A., Beard, Daniel A., Viale, Andrea, Zhang, Ji, Crawford, Howard C., Pasca di Magliano, Marina, Jorgensen, Claus, Lyssiotis, Costas A.
Publicado 2022