Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties

por Alexandre, Thomas, Rayna, Bertrand, Munier-Lehmann, Hélène
Publicado 2015

Correction: Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties

por Alexandre, Thomas, Raynal, Bertrand, Munier-Lehmann, Hélène
Publicado 2015

Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation(†)

por Labesse, Gilles, Benkali, Khaled, Salard-Arnaud, Isabelle, Gilles, Anne-Marie, Munier-Lehmann, Hélène
Publicado 2011

1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase

por Jian, Yanlin, Risseeuw, Martijn D. P., Froeyen, Mathy, Song, Lijun, Cappoen, Davie, Cos, Paul, Munier-Lehmann, Hélène, van Calenbergh, Serge
Publicado 2019

1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

por Jian, Yanlin, Hulpia, Fabian, D. P. Risseeuw, Martijn, Forbes, He Eun, Caljon, Guy, Munier-Lehmann, Hélène, I. M. Boshoff, Helena, Van Calenbergh, Serge
Publicado 2020

Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response

por Lucas-Hourani, Marianne, Dauzonne, Daniel, Munier-Lehmann, Hélène, Khiar, Samira, Nisole, Sébastien, Dairou, Julien, Helynck, Olivier, Afonso, Philippe V., Tangy, Frédéric, Vidalain, Pierre-Olivier
Publicado 2017

Screening of potential antiviral molecules against equid herpesvirus-1 using cellular impedance measurement: Dataset of 2,891 compounds.

por Thieulent, Côme, Fortier, Christine, Munier-Lehmann, Hélène, Suzanne, Peggy, Dallemagne, Patrick, Zientara, Stephan, Hans, Aymeric, Paillot, Romain, Vidalain, Pierre-Olivier, Pronost, Stéphane, Hue, Erika
Publicado 2020

Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors

por Valle-Casuso, José-Carlos, Gaudaire, Delphine, Martin-Faivre, Lydie, Madeline, Anthony, Dallemagne, Patrick, Pronost, Stéphane, Munier-Lehmann, Hélène, Zientara, Stephan, Vidalain, Pierre-Olivier, Hans, Aymeric
Publicado 2020

Identification of a small molecule that primes the type I interferon response to cytosolic DNA

por Khiar, Samira, Lucas-Hourani, Marianne, Nisole, Sébastien, Smith, Nikaïa, Helynck, Olivier, Bourgine, Maryline, Ruffié, Claude, Herbeuval, Jean-Philippe, Munier-Lehmann, Hélène, Tangy, Frédéric, Vidalain, Pierre-Olivier
Publicado 2017

High Content Analysis of Primary Macrophages Hosting Proliferating Leishmania Amastigotes: Application to Anti-leishmanial Drug Discovery

por Aulner, Nathalie, Danckaert, Anne, Rouault-Hardoin, Eline, Desrivot, Julie, Helynck, Olivier, Commere, Pierre-Henri, Munier-Lehmann, Hélène, Späth, Gerald F., Shorte, Spencer L., Milon, Geneviève, Prina, Eric
Publicado 2013

AutomiG, a Biosensor to Detect Alterations in miRNA Biogenesis and in Small RNA Silencing Guided by Perfect Target Complementarity

por Carré, Clément, Jacquier, Caroline, Bougé, Anne-Laure, de Chaumont, Fabrice, Besnard-Guerin, Corinne, Thomassin, Hélène, Pidoux, Josette, Da Silva, Bruno, Chalatsi, Eleftheria, Zahra, Sarah, Olivo-Marin, Jean-Christophe, Munier-Lehmann, Hélène, Antoniewski, Christophe
Publicado 2013

Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands

por Zhou, Zhicheng, Staropoli, Isabelle, Brelot, Anne, Suzanne, Peggy, Lesnard, Aurélien, Fontaine, Fanny, Perato, Serge, Rault, Sylvain, Helynck, Olivier, Arenzana-Seisdedos, Fernando, Sopkova-de Oliveira Santos, Jana, Lagane, Bernard, Munier-Lehmann, Hélène, Colin, Philippe
Publicado 2023

Novel Antiviral Molecules against Ebola Virus Infection

por Collados Rodríguez, Mila, Maillard, Patrick, Journeaux, Alexandra, Komarova, Anastassia V., Najburg, Valérie, David, Raul-Yusef Sanchez, Helynck, Olivier, Guo, Mingzhe, Zhong, Jin, Baize, Sylvain, Tangy, Frédéric, Jacob, Yves, Munier-Lehmann, Hélène, Meurs, Eliane F.
Publicado 2023

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A

por Harigua-Souiai, Emna, Abdelkrim, Yosser Zina, Bassoumi-Jamoussi, Imen, Zakraoui, Ons, Bouvier, Guillaume, Essafi-Benkhadir, Khadija, Banroques, Josette, Desdouits, Nathan, Munier-Lehmann, Hélène, Barhoumi, Mourad, Tanner, N. Kyle, Nilges, Michael, Blondel, Arnaud, Guizani, Ikram
Publicado 2018

Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity

por Lucas-Hourani, Marianne, Dauzonne, Daniel, Jorda, Pierre, Cousin, Gaëlle, Lupan, Alexandru, Helynck, Olivier, Caignard, Grégory, Janvier, Geneviève, André-Leroux, Gwénaëlle, Khiar, Samira, Escriou, Nicolas, Desprès, Philippe, Jacob, Yves, Munier-Lehmann, Hélène, Tangy, Frédéric, Vidalain, Pierre-Olivier
Publicado 2013

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

por Lucas-Hourani, Marianne, Munier-Lehmann, Hélène, El Mazouni, Farah, Malmquist, Nicholas A., Harpon, Jane, Coutant, Eloi P., Guillou, Sandrine, Helynck, Olivier, Noel, Anne, Scherf, Artur, Phillips, Margaret A., Tangy, Frédéric, Vidalain, Pierre-Olivier, Janin, Yves L.
Publicado 2015

SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression

por Cioetto-Mazzabò, Laura, Boldrin, Francesca, Beauvineau, Claire, Speth, Martin, Marina, Alberto, Namouchi, Amine, Segafreddo, Greta, Cimino, Mena, Favre-Rochex, Sandrine, Balasingham, Seetha, Trastoy, Beatriz, Munier-Lehmann, Hélène, Griffiths, Gareth, Gicquel, Brigitte, Guerin, Marcelo E, Manganelli, Riccardo, Alonso-Rodríguez, Noelia
Publicado 2022

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT

por Dabo, Stephanie, Maillard, Patrick, Collados Rodriguez, Milagros, Hansen, Marianne Doré, Mazouz, Sabrina, Bigot, Donna-Joe, Tible, Marion, Janvier, Geneviève, Helynck, Olivier, Cassonnet, Patricia, Jacob, Yves, Bellalou, Jacques, Gatignol, Anne, Patel, Rekha C., Hugon, Jacques, Munier-Lehmann, Hélène, Meurs, Eliane F.
Publicado 2017

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

por Lavigne, Marc, Helynck, Olivier, Rigolet, Pascal, Boudria-Souilah, Rofia, Nowakowski, Mireille, Baron, Bruno, Brülé, Sébastien, Hoos, Sylviane, Raynal, Bertrand, Guittat, Lionel, Beauvineau, Claire, Petres, Stéphane, Granzhan, Anton, Guillon, Jean, Pratviel, Geneviève, Teulade-Fichou, Marie-Paule, England, Patrick, Mergny, Jean-Louis, Munier-Lehmann, Hélène
Publicado 2021

Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

por Magnotti, Flora, Chirita, Daria, Dalmon, Sarah, Martin, Amandine, Bronnec, Pauline, Sousa, Jeremy, Helynck, Olivier, Lee, Wonyong, Kastner, Daniel L., Chae, Jae Jin, McDermott, Michael F., Belot, Alexandre, Popoff, Michel, Sève, Pascal, Georgin-Lavialle, Sophie, Munier-Lehmann, Hélène, Tran, Tu Anh, De Langhe, Ellen, Wouters, Carine, Jamilloux, Yvan, Henry, Thomas
Publicado 2022