Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits

por Shafqat, Naeem, Muniz, Joao R. C., Pilka, Ewa S., Papagrigoriou, Evangelos, vonDelft, Frank, Oppermann, Udo, Yue, Wyatt W.
Publicado 2013

Enzymatic and Structural Characterization of rTSγ Provides Insights into the Function of rTSβ

por Wichelecki, Daniel J., Froese, D. Sean, Kopec, Jolanta, Muniz, Joao R.C., Yue, Wyatt W., Gerlt, John A.
Publicado 2014

Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases

por Muniz, João R.C., Guo, Kunde, Kershaw, Nadia J., Ayinampudi, Vikram, von Delft, Frank, Babon, Jeffrey J., Bullock, Alex N.
Publicado 2013

The two eIF4A helicases in Trypanosoma brucei are functionally distinct

por Dhalia, Rafael, Marinsek, Nina, Reis, Christian R. S., Katz, Rodolfo, Muniz, João R. C., Standart, Nancy, Carrington, Mark, de Melo Neto, Osvaldo P.
Publicado 2006

Systematic studies of the interactions between a model polyphenol compound and microbial β-glucosidases

por da Silva, Viviam M., Sato, Juliana A. P., Araujo, Juscemácia N., Squina, Fabio M., Muniz, João R. C., Riske, Karin A., Garcia, Wanius
Publicado 2017

Structure of a KirBac potassium channel with an open bundle-crossing indicates a mechanism of channel gating

por Bavro, Vassiliy N., De Zorzi, Rita, Schmidt, Matthias R., Muniz, Joao R.C., Zubcevic, Lejla, Sansom, Mark S.P., Vénien-Bryan, Catherine, Tucker, Stephen J.
Publicado 2012

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

por Ferguson, Fleur M., Fedorov, Oleg, Chaikuad, Apirat, Philpott, Martin, Muniz, Joao R. C., Felletar, Ildiko, von Delft, Frank, Heightman, Tom, Knapp, Stefan, Abell, Chris, Ciulli, Alessio
Publicado 2013

Control of KirBac3.1 Potassium Channel Gating at the Interface between Cytoplasmic Domains

por Zubcevic, Lejla, Bavro, Vassiliy N., Muniz, Joao R. C., Schmidt, Matthias R., Wang, Shizhen, De Zorzi, Rita, Venien-Bryan, Catherine, Sansom, Mark S. P., Nichols, Colin G., Tucker, Stephen J.
Publicado 2014

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using en...

por Tsoumpra, Maria K., Muniz, Joao R., Barnett, Bobby L., Kwaasi, Aaron A., Pilka, Ewa S., Kavanagh, Kathryn L., Evdokimov, Artem, Walter, Richard L., Von Delft, Frank, Ebetino, Frank H., Oppermann, Udo, Russell, R. Graham G., Dunford, James E.
Publicado 2015

Ribosomal Oxygenases are Structurally Conserved from Prokaryotes to Humans

por Chowdhury, Rasheduzzaman, Sekirnik, Rok, Brissett, Nigel C., Krojer, Tobias, Ho, Chia-hua, Ng, Stanley S., Clifton, Ian J., Ge, Wei, Kershaw, Nadia J., Fox, Gavin C., Muniz, Joao R. C., Vollmar, Melanie, Phillips, Claire, Pilka, Ewa S., Kavanagh, Kathryn L., von Delft, Frank, Oppermann, Udo, McDonough, Michael A., Doherty, Aiden J., Schofield, Christopher J.
Publicado 2014