PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease

por Kazlauskaite, Agne, Muqit, Miratul M K
Publicado 2015

Ubiquitin and Parkinson's disease through the looking glass of genetics

por Walden, Helen, Muqit, Miratul M.K.
Publicado 2017

A meeting of minds: Overcoming roadblocks in the development of therapies for neurodegenerative disorders

por Muqit, Miratul M K, Alessi, Dario R
Publicado 2009

Whole proteome copy number dataset in primary mouse cortical neurons

por Antico, Odetta, Nirujogi, Raja S., Muqit, Miratul M.K.
Publicado 2023

A Versatile Strategy for the Semisynthetic Production of Ser65 Phosphorylated Ubiquitin and Its Biochemical and Structural Characterisation

por Han, Cong, Pao, Kuan-Chuan, Kazlauskaite, Agne, Muqit, Miratul M K, Virdee, Satpal
Publicado 2015

Are PARKIN patients ideal candidates for dopaminergic cell replacement therapies?

por Kunath, Tilo, Natalwala, Ammar, Chan, Claire, Chen, Yixi, Stecher, Benjamin, Taylor, Martin, Khan, Sadaquate, Muqit, Miratul M. K.
Publicado 2019

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser(65)

por Kazlauskaite, Agne, Kondapalli, Chandana, Gourlay, Robert, Campbell, David G., Ritorto, Maria Stella, Hofmann, Kay, Alessi, Dario R., Knebel, Axel, Trost, Matthias, Muqit, Miratul M. K.
Publicado 2014

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

por McWilliams, Thomas G., Prescott, Alan R., Allen, George F.G., Tamjar, Jevgenia, Munson, Michael J., Thomson, Calum, Muqit, Miratul M.K., Ganley, Ian G.
Publicado 2016

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

por McWilliams, Thomas G., Prescott, Alan R., Montava-Garriga, Lambert, Ball, Graeme, Singh, François, Barini, Erica, Muqit, Miratul M.K., Brooks, Simon P., Ganley, Ian G.
Publicado 2018

Probes of Ubiquitin E3 ligases distinguish different stages of Parkin activation

por Pao, Kuan-Chuan, Stanley, Mathew, Han, Cong, Lai, Yu-Chiang, Murphy, Paul, Balk, Kristin, Wood, Nicola T., Corti, Olga, Corvol, Jean-Christophe, Muqit, Miratul M.K., Virdee, Satpal
Publicado 2016

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

por Barini, Erica, Miccoli, Ageo, Tinarelli, Federico, Mulholland, Katie, Kadri, Hachemi, Khanim, Farhat, Stojanovski, Laste, Read, Kevin D., Burness, Kerry, Blow, Julian J., Mehellou, Youcef, Muqit, Miratul M. K.
Publicado 2018

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72

por Vieweg, Sophie, Mulholland, Katie, Bräuning, Bastian, Kachariya, Nitin, Lai, Yu-Chiang, Toth, Rachel, Singh, Pawan Kishor, Volpi, Ilaria, Sattler, Michael, Groll, Michael, Itzen, Aymelt, Muqit, Miratul M. K.
Publicado 2020

The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons

por Iovino, Mariangela, Pfisterer, Ulrich, Holton, Janice L., Lashley, Tammaryn, Swingler, Robert J., Calo, Laura, Treacy, Rebecca, Revesz, Tamas, Parmar, Malin, Goedert, Michel, Muqit, Miratul M. K., Spillantini, Maria Grazia
Publicado 2013

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

por Kazlauskaite, Agne, Kelly, Van, Johnson, Clare, Baillie, Carla, Hastie, C. James, Peggie, Mark, Macartney, Thomas, Woodroof, Helen I., Alessi, Dario R., Pedrioli, Patrick G. A., Muqit, Miratul M. K.
Publicado 2014

Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization

por Osgerby, Laura, Lai, Yu-Chiang, Thornton, Peter J., Amalfitano, Joseph, Le Duff, Cécile S., Jabeen, Iqra, Kadri, Hachemi, Miccoli, Ageo, Tucker, James H. R., Muqit, Miratul M. K., Mehellou, Youcef
Publicado 2017

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations

por Woodroof, Helen I., Pogson, Joe H., Begley, Mike, Cantley, Lewis C., Deak, Maria, Campbell, David G., van Aalten, Daan M. F., Whitworth, Alexander J., Alessi, Dario R., Muqit, Miratul M. K.
Publicado 2011

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1

por Antico, Odetta, Ordureau, Alban, Stevens, Michael, Singh, Francois, Nirujogi, Raja S., Gierlinski, Marek, Barini, Erica, Rickwood, Mollie L., Prescott, Alan, Toth, Rachel, Ganley, Ian G., Harper, J. Wade, Muqit, Miratul M. K.
Publicado 2021

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

por Kondapalli, Chandana, Kazlauskaite, Agne, Zhang, Ning, Woodroof, Helen I., Campbell, David G., Gourlay, Robert, Burchell, Lynn, Walden, Helen, Macartney, Thomas J., Deak, Maria, Knebel, Axel, Alessi, Dario R., Muqit, Miratul M. K.
Publicado 2012

Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells

por Kakade, Poonam, Ojha, Hina, Raimi, Olawale G., Shaw, Andrew, Waddell, Andrew D., Ault, James R., Burel, Sophie, Brockmann, Kathrin, Kumar, Atul, Ahangar, Mohd Syed, Krysztofinska, Ewelina M., Macartney, Thomas, Bayliss, Richard, Fitzgerald, Julia C., Muqit, Miratul M. K.
Publicado 2022

TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

por Flinn, Laura J., Keatinge, Marcus, Bretaud, Sandrine, Mortiboys, Heather, Matsui, Hideaki, De Felice, Elena, Woodroof, Helen I., Brown, Lucy, McTighe, Aimee, Soellner, Rosemarie, Allen, Claire E., Heath, Paul R., Milo, Marta, Muqit, Miratul M. K., Reichert, Andreas S., Köster, Reinhard W., Ingham, Philip W., Bandmann, Oliver
Publicado 2014