Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non–Cell Autonomous Liver Carcinogenesis

por Makino, Yuki, Hikita, Hayato, Fukumoto, Kenji, Sung, Ji Hyun, Sakano, Yoshihiro, Murai, Kazuhiro, Sakane, Sadatsugu, Kodama, Takahiro, Sakamori, Ryotaro, Kondo, Jumpei, Kobayashi, Shogo, Tatsumi, Tomohide, Takehara, Tetsuo
Publicado 2022

The First Case of Coil Embolization for Left Gastric Vein Aneurysm with Liver Cirrhosis: A Case Report and Review of the Literature

por Kato, Seiya, Sakamori, Ryotaro, Yamada, Ryoko, Murai, Kazuhiro, Yoshioka, Teppei, Tahata, Yuki, Shigekawa, Minoru, Kodama, Takahiro, Hikita, Hayato, Hongyo, Hidenari, Ono, Yusuke, Higashihara, Hiroki, Tatsumi, Tomohide, Takehara, Tetsuo
Publicado 2021

Hyperglycemia enhances pancreatic cancer progression accompanied by elevations in phosphorylated STAT3 and MYC levels

por Sato, Katsuhiko, Hikita, Hayato, Myojin, Yuta, Fukumoto, Kenji, Murai, Kazuhiro, Sakane, Sadatsugu, Tamura, Takeshi, Yamai, Takuo, Nozaki, Yasutoshi, Yoshioka, Teppei, Kodama, Takahiro, Shigekawa, Minoru, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Publicado 2020

Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regener...

por Nozaki, Yasutoshi, Hikita, Hayato, Tanaka, Satoshi, Fukumoto, Kenji, Urabe, Makiko, Sato, Katsuhiko, Myojin, Yuta, Doi, Akira, Murai, Kazuhiro, Sakane, Sadatsugu, Saito, Yoshinobu, Kodama, Takahiro, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Publicado 2021

Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver

por Nakabori, Tasuku, Hikita, Hayato, Murai, Kazuhiro, Nozaki, Yasutoshi, Kai, Yugo, Makino, Yuki, Saito, Yoshinobu, Tanaka, Satoshi, Wada, Hiroshi, Eguchi, Hidetoshi, Takahashi, Takeshi, Suemizu, Hiroshi, Sakamori, Ryotaro, Hiramatsu, Naoki, Tatsumi, Tomohide, Takehara, Tetsuo
Publicado 2016

Capsid Allosteric Modulators Enhance the Innate Immune Response in Hepatitis B Virus–Infected Hepatocytes During Interferon Administration

por Fukutomi, Keisuke, Hikita, Hayato, Murai, Kazuhiro, Nakabori, Tasuku, Shimoda, Akiyoshi, Fukuoka, Makoto, Yamai, Takuo, Higuchi, Yuichiro, Miyakawa, Kei, Suemizu, Hiroshi, Ryo, Akihide, Yamada, Ryoko, Kodama, Takahiro, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Publicado 2021

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation...

por Shiode, Yuto, Kodama, Takahiro, Shigeno, Satoshi, Murai, Kazuhiro, Tanaka, Satoshi, Newberg, Justin Y., Kondo, Jumpei, Kobayashi, Shogo, Yamada, Ryoko, Hikita, Hayato, Sakamori, Ryotaro, Suemizu, Hiroshi, Tatsumi, Tomohide, Eguchi, Hidetoshi, Jenkins, Nancy A., Copeland, Neal G., Takehara, Tetsuo
Publicado 2023

Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway

por Murai, Kazuhiro, Hikita, Hayato, Kai, Yugo, Kondo, Yasuteru, Fukuoka, Makoto, Fukutomi, Keisuke, Doi, Akira, Yamai, Takuo, Nakabori, Tasuku, Fukuda, Ryo, Takahashi, Takeshi, Miyakawa, Kei, Suemizu, Hiroshi, Ryo, Akihide, Yamada, Ryoko, Kodama, Takahiro, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Publicado 2020

Inhibition of nonhomologous end joining‐mediated DNA repair enhances anti‐HBV CRISPR therapy

por Murai, Kazuhiro, Kodama, Takahiro, Hikita, Hayato, Shimoda, Akiyoshi, Fukuoka, Makoto, Fukutomi, Keisuke, Shigeno, Satoshi, Shiode, Yuto, Motooka, Daisuke, Higuchi, Yuichiro, Miyakawa, Kei, Suemizu, Hiroshi, Ryo, Akihide, Tahata, Yuki, Makino, Yuki, Yamada, Ryoko, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Publicado 2022

STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression

por Makino, Yuki, Hikita, Hayato, Kato, Seiya, Sugiyama, Masaya, Shigekawa, Minoru, Sakamoto, Tatsuya, Sasaki, Yoichi, Murai, Kazuhiro, Sakane, Sadatsugu, Kodama, Takahiro, Sakamori, Ryotaro, Kobayashi, Shogo, Eguchi, Hidetoshi, Takemura, Nobuyuki, Kokudo, Norihiro, Yokoi, Hideki, Mukoyama, Masashi, Tatsumi, Tomohide, Takehara, Tetsuo
Publicado 2022

Pentraxin 3 is an adipose tissue‐related serum marker for pancreatic cancer cachexia predicting subsequent muscle mass and visceral fat loss

por Sato, Katsuhiko, Hikita, Hayato, Shigekawa, Minoru, Kato, Seiya, Sasaki, Yoichi, Shinkai, Kazuma, Fukuoka, Makoto, Kudo, Shinnosuke, Sato, Yu, Fukumoto, Kenji, Shirai, Kumiko, Myojin, Yuta, Sakane, Sadatsugu, Murai, Kazuhiro, Yoshioka, Teppei, Nishio, Akira, Kodama, Takahiro, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Publicado 2022

Fucosylated haptoglobin is a novel predictive marker of hepatocellular carcinoma after hepatitis C virus elimination in patients with advanced liver fibrosis

por Shirai, Kumiko, Hikita, Hayato, Sakamori, Ryotaro, Doi, Akira, Tahata, Yuki, Sakane, Sadatsugu, Kamada, Yoshihiro, Murai, Kazuhiro, Nishio, Akira, Yamada, Ryoko, Kodama, Takahiro, Nozaki, Yasutoshi, Kakita, Naruyasu, Ishida, Hisashi, Nakanishi, Fumihiko, Morishita, Naoki, Imanaka, Kazuho, Sakakibara, Mitsuru, Tatsumi, Tomohide, Miyoshi, Eiji, Takehara, Tetsuo
Publicado 2022

Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment

por Kai, Yugo, Hikita, Hayato, Morishita, Naoki, Murai, Kazuhiro, Nakabori, Tasuku, Iio, Sadaharu, Hagiwara, Hideki, Imai, Yasuharu, Tamura, Shinji, Tsutsui, Syusaku, Naito, Masafumi, Nishiuchi, Meiko, Kondo, Yasuteru, Kato, Takanobu, Suemizu, Hiroshi, Yamada, Ryoko, Oze, Tsugiko, Yakushijin, Takayuki, Hiramatsu, Naoki, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Publicado 2017