Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion

por Sekiya, Motohiro, Matsuda, Takaaki, Yamamoto, Yuki, Furuta, Yasuhisa, Ohyama, Mariko, Murayama, Yuki, Sugano, Yoko, Ohsaki, Yoshinori, Iwasaki, Hitoshi, Yahagi, Naoya, Yatoh, Shigeru, Suzuki, Hiroaki, Shimano, Hitoshi
Publicado 2020

FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin

por Takeuchi, Yoshinori, Yahagi, Naoya, Aita, Yuichi, Mehrazad-Saber, Zahra, Ho, Man Hei, Huyan, Yiren, Murayama, Yuki, Shikama, Akito, Masuda, Yukari, Izumida, Yoshihiko, Miyamoto, Takafumi, Matsuzaka, Takashi, Kawakami, Yasushi, Shimano, Hitoshi
Publicado 2021

New balance capability index as a screening tool for mild cognitive impairment

por Suzuki, Yasuhiro, Tsubaki, Takumi, Nakaya, Kensuke, Kondo, Genta, Takeuchi, Yoshinori, Aita, Yuichi, Murayama, Yuki, Shikama, Akito, Masuda, Yukari, Suzuki, Hiroaki, Kawakami, Yasushi, Shimano, Hitoshi, Arai, Tetsuaki, Hada, Yasushi, Yahagi, Naoya
Publicado 2023

A case of early-onset diabetes with impaired insulin secretion carrying a PAX6 gene Gln135* mutation

por Sekiya, Motohiro, Yuhara, Mikiko, Murayama, Yuki, Ohyama Osawa, Mariko, Nakajima, Rikako, Ohuchi, Nami, Matsumoto, Nako, Yamazaki, Daichi, Mori, Sayuri, Matsuda, Takaaki, Sugano, Yoko, Osaki, Yoshinori, Iwasaki, Hitoshi, Suzuki, Hiroaki, Shimano, Hitoshi
Publicado 2022

Selective peroxisome proliferator‐activated receptor‐α modulator K‐877 efficiently activates the peroxisome proliferator‐activated receptor‐α pathway and improves lipid metabolism...

por Takei, Kenta, Han, Song‐iee, Murayama, Yuki, Satoh, Aoi, Oikawa, Fusaka, Ohno, Hiroshi, Osaki, Yoshinori, Matsuzaka, Takashi, Sekiya, Motohiro, Iwasaki, Hitoshi, Yatoh, Shigeru, Yahagi, Naoya, Suzuki, Hiroaki, Yamada, Nobuhiro, Nakagawa, Yoshimi, Shimano, Hitoshi
Publicado 2017

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms

por Satoh, Aoi, Han, Song-iee, Araki, Masaya, Nakagawa, Yoshimi, Ohno, Hiroshi, Mizunoe, Yuhei, Kumagai, Kae, Murayama, Yuki, Osaki, Yoshinori, Iwasaki, Hitoshi, Sekiya, Motohiro, Konishi, Morichika, Itoh, Nobuyuki, Matsuzaka, Takashi, Sone, Hirohito, Shimano, Hitoshi
Publicado 2020

Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition

por Nakagawa, Yoshimi, Wang, Yunong, Han, Song-iee, Okuda, Kanako, Oishi, Asayo, Yagishita, Yuka, Kumagai, Kae, Ohno, Hiroshi, Osaki, Yoshinori, Mizunoe, Yuhei, Araki, Masaya, Murayama, Yuki, Iwasaki, Hitoshi, Konishi, Morichika, Itoh, Nobuyuki, Matsuzaka, Takashi, Sone, Hirohito, Yamada, Nobuhiro, Shimano, Hitoshi
Publicado 2020

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids

por Han, Song-Iee, Nakakuki, Masanori, Nakagawa, Yoshimi, Wang, Yunong, Araki, Masaya, Yamamoto, Yuta, Tokiwa, Hiroaki, Takeda, Hiroyuki, Mizunoe, Yuhei, Motomura, Kaori, Ohno, Hiroshi, Kainoh, Kenta, Murayama, Yuki, Aita, Yuichi, Takeuchi, Yoshinori, Osaki, Yoshinori, Miyamoto, Takafumi, Sekiya, Motohiro, Matsuzaka, Takashi, Yahagi, Naoya, Sone, Hirohito, Daitoku, Hiroaki, Sato, Ryuichiro, Kawano, Hiroyuki, Shimano, Hitoshi
Publicado 2023

Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity

por Saito, Kenji, Sekiya, Motohiro, Kainoh, Kenta, Yoshino, Ryunosuke, Hayashi, Akio, Han, Song-Iee, Araki, Masaya, Ohno, Hiroshi, Takeuchi, Yoshinori, Tsuyuzaki, Tomomi, Yamazaki, Daichi, Wanpei, Chen, Hada, Lisa, Watanabe, Sho, Paramita Adi Putri, Putu Indah, Murayama, Yuki, Sugano, Yoko, Osaki, Yoshinori, Iwasaki, Hitoshi, Yahagi, Naoya, Suzuki, Hiroaki, Miyamoto, Takafumi, Matsuzaka, Takashi, Shimano, Hitoshi
Publicado 2023

A case of NASH with genetic predisposition successfully treated with an SGLT2 inhibitor: a possible involvement of mitochondrial dysfunction

por Nakajima, Rikako, Sekiya, Motohiro, Furuta, Yasuhisa, Miyamoto, Takafumi, Sato, Masashi, Fukuda, Kuniaki, Hattori, Keiichiro, Suehara, Yasuhito, Sakata-Yanagimoto, Mamiko, Chiba, Shigeru, Okajima, Yuka, Matsuzaka, Takashi, Takase, Satoru, Takanashi, Mikio, Okazaki, Hiroaki, Takashima, Yusuke, Yuhara, Mikiko, Mitani, Yuta, Matsumoto, Nako, Murayama, Yuki, Ohyama Osawa, Mariko, Ohuchi, Nami, Yamazaki, Daichi, Mori, Sayuri, Sugano, Yoko, Osaki, Yoshinori, Iwasaki, Hitoshi, Suzuki, Hiroaki, Shimano, Hitoshi
Publicado 2022