Dynamic Stromal Alterations Influence Tumor-Stroma Crosstalk to Promote Pancreatic Cancer and Treatment Resistance

por Murphy, Kendelle J., Chambers, Cecilia R., Herrmann, David, Timpson, Paul, Pereira, Brooke A.
Publicado 2021

Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy

por Murphy, Kendelle J., Zhu, Jessie, Trpceski, Michael, Pereira, Brooke A., Timpson, Paul, Herrmann, David
Publicado 2022

Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology

por Conway, James R. W., Vennin, Claire, Cazet, Aurélie S., Herrmann, David, Murphy, Kendelle J., Warren, Sean C., Wullkopf, Lena, Boulghourjian, Alice, Zaratzian, Anaiis, Da Silva, Andrew M., Pajic, Marina, Morton, Jennifer P., Cox, Thomas R., Timpson, Paul
Publicado 2017

Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions

por Jose, Jaimy, Hoque, Monira, Engel, Johanna, Beevi, Syed S., Wahba, Mohamed, Georgieva, Mariya Ilieva, Murphy, Kendelle J., Hughes, William E., Cochran, Blake J., Lu, Albert, Tebar, Francesc, Hoy, Andrew J., Timpson, Paul, Rye, Kerry-Anne, Enrich, Carlos, Rentero, Carles, Grewal, Thomas
Publicado 2022

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma

por Castillo, Lesley, Young, Adelaide I. J., Mawson, Amanda, Schafranek, Pia, Steinmann, Angela M., Nessem, Danielle, Parkin, Ashleigh, Johns, Amber, Chou, Angela, Law, Andrew M. K., Lucas, Morghan C., Murphy, Kendelle J., Deng, Niantao, Gallego-Ortega, David, Caldon, Catherine E., Timpson, Paul, Pajic, Marina, Ormandy, Christopher J., Oakes, Samantha R.
Publicado 2019

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer

por Kennedy, Sean P., Han, Jeremy Z. R., Portman, Neil, Nobis, Max, Hastings, Jordan F., Murphy, Kendelle J., Latham, Sharissa L., Cadell, Antonia L., Miladinovic, Dushan, Marriott, Gabriella R., O’Donnell, Yolande E. I., Shearer, Robert F., Williams, James T., Munoz, Amaya Garcia, Cox, Thomas R., Watkins, D. Neil, Saunders, Darren N., Timpson, Paul, Lim, Elgene, Kolch, Walter, Croucher, David R.
Publicado 2019

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer

por Conway, James R.W., Warren, Sean C., Herrmann, David, Murphy, Kendelle J., Cazet, Aurélie S., Vennin, Claire, Shearer, Robert F., Killen, Monica J., Magenau, Astrid, Mélénec, Pauline, Pinese, Mark, Nobis, Max, Zaratzian, Anaiis, Boulghourjian, Alice, Da Silva, Andrew M., del Monte-Nieto, Gonzalo, Adam, Arne S.A., Harvey, Richard P., Haigh, Jody J., Wang, Yingxiao, Croucher, David R., Sansom, Owen J., Pajic, Marina, Caldon, C. Elizabeth, Morton, Jennifer P., Timpson, Paul
Publicado 2018

Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer

por Chou, Angela, Froio, Danielle, Nagrial, Adnan M, Parkin, Ashleigh, Murphy, Kendelle J, Chin, Venessa T, Wohl, Dalia, Steinmann, Angela, Stark, Rhys, Drury, Alison, Walters, Stacey N, Vennin, Claire, Burgess, Andrew, Pinese, Mark, Chantrill, Lorraine A, Cowley, Mark J, Molloy, Timothy J, Waddell, Nicola, Johns, Amber, Grimmond, Sean M, Chang, David K, Biankin, Andrew V, Sansom, Owen J, Morton, Jennifer P, Grey, Shane T, Cox, Thomas R, Turchini, John, Samra, Jaswinder, Clarke, Stephen J, Timpson, Paul, Gill, Anthony J, Pajic, Marina
Publicado 2018

Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis

por Papanicolaou, Michael, Parker, Amelia L., Yam, Michelle, Filipe, Elysse C., Wu, Sunny Z., Chitty, Jessica L., Wyllie, Kaitlin, Tran, Emmi, Mok, Ellie, Nadalini, Audrey, Skhinas, Joanna N., Lucas, Morghan C., Herrmann, David, Nobis, Max, Pereira, Brooke A., Law, Andrew M. K., Castillo, Lesley, Murphy, Kendelle J., Zaratzian, Anaiis, Hastings, Jordan F., Croucher, David R., Lim, Elgene, Oliver, Brian G., Mora, Fatima Valdes, Parker, Benjamin L., Gallego-Ortega, David, Swarbrick, Alexander, O’Toole, Sandra, Timpson, Paul, Cox, Thomas R.
Publicado 2022

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

por Vennin, Claire, Mélénec, Pauline, Rouet, Romain, Nobis, Max, Cazet, Aurélie S., Murphy, Kendelle J., Herrmann, David, Reed, Daniel A., Lucas, Morghan C., Warren, Sean C., Elgundi, Zehra, Pinese, Mark, Kalna, Gabriella, Roden, Daniel, Samuel, Monisha, Zaratzian, Anaiis, Grey, Shane T., Da Silva, Andrew, Leung, Wilfred, Mathivanan, Suresh, Wang, Yingxiao, Braithwaite, Anthony W., Christ, Daniel, Benda, Ales, Parkin, Ashleigh, Phillips, Phoebe A., Whitelock, John M., Gill, Anthony J., Sansom, Owen J., Croucher, David R., Parker, Benjamin L., Pajic, Marina, Morton, Jennifer P., Cox, Thomas R., Timpson, Paul
Publicado 2019

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

por Erami, Zahra, Herrmann, David, Warren, Sean C., Nobis, Max, McGhee, Ewan J., Lucas, Morghan C., Leung, Wilfred, Reischmann, Nadine, Mrowinska, Agata, Schwarz, Juliane P., Kadir, Shereen, Conway, James R.W., Vennin, Claire, Karim, Saadia A., Campbell, Andrew D., Gallego-Ortega, David, Magenau, Astrid, Murphy, Kendelle J., Ridgway, Rachel A., Law, Andrew M., Walters, Stacey N., Grey, Shane T., Croucher, David R., Zhang, Lei, Herzog, Herbert, Hardeman, Edna C., Gunning, Peter W., Ormandy, Christopher J., Evans, T.R. Jeffry, Strathdee, Douglas, Sansom, Owen J., Morton, Jennifer P., Anderson, Kurt I., Timpson, Paul
Publicado 2015

Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse

por Conway, James R. W., Warren, Sean C., Lee, Young-Kyung, McCulloch, Andrew T., Magenau, Astrid, Lee, Victoria, Metcalf, Xanthe L., Stoehr, Janett, Haigh, Katharina, Abdulkhalek, Lea, Guaman, Cristian S., Reed, Daniel A., Murphy, Kendelle J., Pereira, Brooke A., Mélénec, Pauline, Chambers, Cecilia, Latham, Sharissa L., Lenthall, Helen, Deenick, Elissa K., Ma, Yuanqing, Phan, Tri, Lim, Elgene, Joshua, Anthony M., Walters, Stacey, Grey, Shane T., Shi, Yan-Chuan, Zhang, Lei, Herzog, Herbert, Croucher, David R., Philp, Andy, Scheele, Colinda L.G.J., Herrmann, David, Sansom, Owen J., Morton, Jennifer P., Papa, Antonella, Haigh, Jody J., Nobis, Max, Timpson, Paul
Publicado 2023

Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status

por Murphy, Kendelle J., Reed, Daniel A., Vennin, Claire, Conway, James R. W., Nobis, Max, Yin, Julia X., Chambers, Cecilia R., Pereira, Brooke A., Lee, Victoria, Filipe, Elysse C., Trpceski, Michael, Ritchie, Shona, Lucas, Morghan C., Warren, Sean C., Skhinas, Joanna N., Magenau, Astrid, Metcalf, Xanthe L., Stoehr, Janett, Major, Gretel, Parkin, Ashleigh, Bidanel, Romain, Lyons, Ruth J., Zaratzian, Anaiis, Tayao, Michael, Da Silva, Andrew, Abdulkhalek, Lea, Gill, Anthony J., Johns, Amber L., Biankin, Andrew V., Samra, Jaswinder, Grimmond, Sean M., Chou, Angela, Goetz, Jacky G., Samuel, Michael S., Lyons, J. Guy, Burgess, Andrew, Caldon, C. Elizabeth, Horvath, Lisa G., Daly, Roger J., Gadegaard, Nikolaj, Wang, Yingxiao, Sansom, Owen J., Morton, Jennifer P., Cox, Thomas R., Pajic, Marina, Herrmann, David, Timpson, Paul
Publicado 2021

A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

por Chitty, Jessica L., Yam, Michelle, Perryman, Lara, Parker, Amelia L., Skhinas, Joanna N., Setargew, Yordanos F. I., Mok, Ellie T. Y., Tran, Emmi, Grant, Rhiannon D., Latham, Sharissa L., Pereira, Brooke A., Ritchie, Shona C., Murphy, Kendelle J., Trpceski, Michael, Findlay, Alison D., Melenec, Pauline, Filipe, Elysse C., Nadalini, Audrey, Velayuthar, Sipiththa, Major, Gretel, Wyllie, Kaitlin, Papanicolaou, Michael, Ratnaseelan, Shivanjali, Phillips, Phoebe A., Sharbeen, George, Youkhana, Janet, Russo, Alice, Blackwell, Antonia, Hastings, Jordan F., Lucas, Morghan C., Chambers, Cecilia R., Reed, Daniel A., Stoehr, Janett, Vennin, Claire, Pidsley, Ruth, Zaratzian, Anaiis, Da Silva, Andrew M., Tayao, Michael, Charlton, Brett, Herrmann, David, Nobis, Max, Clark, Susan J., Biankin, Andrew V., Johns, Amber L., Croucher, David R., Nagrial, Adnan, Gill, Anthony J., Grimmond, Sean M., Pajic, Marina, Timpson, Paul, Jarolimek, Wolfgang, Cox, Thomas R.
Publicado 2023