Bioinformatic identification of previously unrecognized amyloidogenic proteins

por Rosenberg, Gregory M., Murray, Kevin A., Salwinski, Lukasz, Hughes, Michael P., Abskharon, Romany, Eisenberg, David S.
Publicado 2022

Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation

por Shin, Woo Shik, Di, Jing, Murray, Kevin A., Sun, Chuanqi, Li, Binsen, Bitan, Gal, Jiang, Lin
Publicado 2019

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

por Shin, Woo Shik, Di, Jing, Cao, Qin, Li, Binsen, Seidler, Paul M., Murray, Kevin A., Bitan, Gal, Jiang, Lin
Publicado 2019

Correction to: Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

por Shin, Woo Shik, Di, Jing, Cao, Qin, Li, Binsen, Seidler, Paul M., Murray, Kevin A., Bitan, Gal, Jiang, Lin
Publicado 2021

Inhibition of synucleinopathic seeding by rationally designed inhibitors

por Sangwan, Smriti, Sahay, Shruti, Murray, Kevin A, Morgan, Sophie, Guenther, Elizabeth L, Jiang, Lin, Williams, Christopher K, Vinters, Harry V, Goedert, Michel, Eisenberg, David S
Publicado 2020

Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies

por Murray, Kevin A., Hughes, Michael P., Hu, Carolyn J., Sawaya, Michael R., Salwinski, Lukasz, Pan, Hope, French, Samuel W., Seidler, Paul M., Eisenberg, David S.
Publicado 2022

De novo designed protein inhibitors of amyloid aggregation and seeding

por Murray, Kevin A., Hu, Carolyn J., Griner, Sarah L., Pan, Hope, Bowler, Jeannette T., Abskharon, Romany, Rosenberg, Gregory M., Cheng, Xinyi, Seidler, Paul M., Eisenberg, David S.
Publicado 2022

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

por Li, Binsen, Ge, Peng, Murray, Kevin A., Sheth, Phorum, Zhang, Meng, Nair, Gayatri, Sawaya, Michael R., Shin, Woo Shik, Boyer, David R., Ye, Shulin, Eisenberg, David S., Zhou, Z. Hong, Jiang, Lin
Publicado 2018

Structure-based inhibitors of amyloid beta core suggest a common interface with tau

por Griner, Sarah L, Seidler, Paul, Bowler, Jeannette, Murray, Kevin A, Yang, Tianxiao Peter, Sahay, Shruti, Sawaya, Michael R, Cascio, Duilio, Rodriguez, Jose A, Philipp, Stephan, Sosna, Justyna, Glabe, Charles G, Gonen, Tamir, Eisenberg, David S
Publicado 2019

Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils

por Murray, Kevin A., Hu, Carolyn J., Pan, Hope, Lu, Jiahui, Abskharon, Romany, Bowler, Jeannette T., Rosenberg, Gregory M., Williams, Christopher K., Elezi, Gazmend, Balbirnie, Melinda, Faull, Kym F., Vinters, Harry V., Seidler, Paul M., Eisenberg, David S.
Publicado 2023

Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro

por Seidler, Paul M., Murray, Kevin A., Boyer, David R., Ge, Peng, Sawaya, Michael R., Hu, Carolyn J., Cheng, Xinyi, Abskharon, Romany, Pan, Hope, DeTure, Michael A., Williams, Christopher K., Dickson, Dennis W., Vinters, Harry V., Eisenberg, David S.
Publicado 2022

Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

por Tayeb-Fligelman, Einav, Bowler, Jeannette T., Tai, Christen E., Sawaya, Michael R., Jiang, Yi Xiao, Garcia, Gustavo, Griner, Sarah L., Cheng, Xinyi, Salwinski, Lukasz, Lutter, Liisa, Seidler, Paul M., Lu, Jiahui, Rosenberg, Gregory M., Hou, Ke, Abskharon, Romany, Pan, Hope, Zee, Chih-Te, Boyer, David R., Li, Yan, Anderson, Daniel H., Murray, Kevin A., Falcon, Genesis, Cascio, Duilio, Saelices, Lorena, Damoiseaux, Robert, Arumugaswami, Vaithilingaraja, Guo, Feng, Eisenberg, David S.
Publicado 2023

Structure-based design of nanobodies that inhibit seeding of Alzheimer’s patient–extracted tau fibrils

por Abskharon, Romany, Pan, Hope, Sawaya, Michael R., Seidler, Paul M., Olivares, Eileen J., Chen, Yu, Murray, Kevin A., Zhang, Jeffrey, Lantz, Carter, Bentzel, Megan, Boyer, David R., Cascio, Duilio, Nguyen, Binh A., Hou, Ke, Cheng, Xinyi, Pardon, Els, Williams, Christopher K., Nana, Alissa L., Vinters, Harry V., Spina, Salvatore, Grinberg, Lea T., Seeley, William W., Steyaert, Jan, Glabe, Charles G., Ogorzalek Loo, Rachel R., Loo, Joseph A., Eisenberg, David S.
Publicado 2023