A New Tumor Suppressor That Regulates Tissue Architecture

por Muthuswamy, Senthil K.
Publicado 2009

3D culture reveals a signaling network

por Muthuswamy, Senthil K
Publicado 2011

Oncogenic GNAS uses PKA-dependent and independent mechanisms to induce cell proliferation in human pancreatic ductal and acinar organoids

por Desai, Ridhdhi, Muthuswamy, Senthil
Publicado 2023

Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer

por Oliphant, Michael UJ, Akshinthala, Dipikaa, Muthuswamy, Senthil K
Publicado 2023

A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells

por Arias-Romero, Luis E., Villamar-Cruz, Olga, Pacheco, Almudena, Kosoff, Rachelle, Huang, Min, Muthuswamy, Senthil K., Chernoff, Jonathan
Publicado 2010

THE SPLICING FACTOR SRSF1 REGULATES APOPTOSIS AND PROLIFERATION TO PROMOTE MAMMARY EPITHELIAL CELL TRANSFORMATION

por Anczuków, Olga, Rosenberg, Avi Z., Akerman, Martin, Das, Shipra, Zhan, Lixing, Karni, Rotem, Muthuswamy, Senthil K., Krainer, Adrian R
Publicado 2012

Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer

por Saito, Yasuhiro, Matsuda, Shiori, Ohnishi, Naomi, Endo, Keiko, Ashitani, Sanae, Ohishi, Maki, Ueno, Ayano, Tomita, Masaru, Ueda, Koji, Soga, Tomoyoshi, Muthuswamy, Senthil K.
Publicado 2022

Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids

por Huang, Ling, Desai, Ridhdhi, Conrad, Daniel N., Leite, Nayara C., Akshinthala, Dipikaa, Lim, Christine Maria, Gonzalez, Raul, Muthuswamy, Lakshmi B., Gartner, Zev, Muthuswamy, Senthil K.
Publicado 2021

Dysregulation of Cell Polarity Proteins Synergize with Oncogenes or the Microenvironment to Induce Invasive Behavior in Epithelial Cells

por Chatterjee, Samit, Seifried, Laurie, Feigin, Michael E., Gibbons, Don L., Scuoppo, Claudio, Lin, Wei, Rizvi, Zain H., Lind, Evan, Dissanayake, Dilan, Kurie, Jonathan, Ohashi, Pam, Muthuswamy, Senthil K.
Publicado 2012

Targeting the disordered C-terminus of PTP1B with an allosteric inhibitor

por Krishnan, Navasona, Koveal, Dorothy, Miller, Daniel H., Xue, Bin, Akshinthala, Sai Dipikaa, Kragelj, Jaka, Jensen, Malene Ringkjøbing, Gauss, Carla-Maria, Page, Rebecca, Blackledge, Martin, Muthuswamy, Senthil K., Peti, Wolfgang, Tonks, Nicholas K.
Publicado 2014

Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids

por Meng, Qingda, Xie, Shanshan, Gray, G Kenneth, Dezfulian, Mohammad H, Gandarilla, Omar, Li, Weilin, Huang, Ling, Akshinthala, Dipikaa, Ferrer, Elizabeth, Conahan, Catherine, Perea Del Pino, Sofia, Grossman, Joseph, Elledge, Stephen J, Hidalgo, Manuel, Muthuswamy, Senthil K
Publicado 2021

Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors

por Chafe, Shawn C., Vizeacoumar, Frederick S., Venkateswaran, Geetha, Nemirovsky, Oksana, Awrey, Shannon, Brown, Wells S., McDonald, Paul C., Carta, Fabrizio, Metcalfe, Andrew, Karasinska, Joanna M., Huang, Ling, Muthuswamy, Senthil K., Schaeffer, David F., Renouf, Daniel J., Supuran, Claudiu T., Vizeacoumar, Franco J., Dedhar, Shoukat
Publicado 2021

Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo

por Sonzogni, Olmo, Haynes, Jennifer, Seifried, Laurie A., Kamel, Yahia M., Huang, Kai, BeGora, Michael D., Yeung, Faith Au, Robert-Tissot, Celine, Heng, Yujing J., Yuan, Xin, Wulf, Gerbug M., Kron, Ken J., Wagenblast, Elvin, Lupien, Mathieu, Kislinger, Thomas, Hannon, Gregory J., Muthuswamy, Senthil K.
Publicado 2018

A Large-Scale Proteomics Resource of Circulating Extracellular Vesicles for Biomarker Discovery in Pancreatic Cancer

por Bockorny, Bruno, Muthuswamy, Lakshmi, Huang, Ling, Hadisurya, Marco, Lim, Christine Maria, Tsai, Leo L., Gill, Ritu R., Wei, Jesse L., Bullock, Andrea J., Grossman, Joseph E., Besaw, Robert J., Narasimhan, Supraja, Tao, W. Andy, Perea, Sofia, Sawhney, Mandeep S., Freedman, Steven D., Hidalgo, Manuel, Iliuk, Anton, Muthuswamy, Senthil K.
Publicado 2023

Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT

por Paul, Indranil, Bolzan, Dante, Youssef, Ahmed, Gagnon, Keith A., Hook, Heather, Karemore, Gopal, Oliphant, Michael U. J., Lin, Weiwei, Liu, Qian, Phanse, Sadhna, White, Carl, Padhorny, Dzmitry, Kotelnikov, Sergei, Chen, Christopher S., Hu, Pingzhao, Denis, Gerald V., Kozakov, Dima, Raught, Brian, Siggers, Trevor, Wuchty, Stefan, Muthuswamy, Senthil K., Emili, Andrew
Publicado 2023

Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer

por Gil Del Alcazar, Carlos R., Trinh, Anne, Alečković, Maša, Rojas Jimenez, Ernesto, Harper, Nicholas W., Oliphant, Michael U.J., Xie, Shanshan, Krop, Ethan D., Lulseged, Bethlehem, Murphy, Katherine C., Keenan, Tanya E., Van Allen, Eliezer M., Tolaney, Sara M., Freeman, Gordon J., Dillon, Deborah A., Muthuswamy, Senthil K., Polyak, Kornelia
Publicado 2022

PDX-derived organoids model in vivo drug response and secrete biomarkers

por Huang, Ling, Bockorny, Bruno, Paul, Indranil, Akshinthala, Dipikaa, Frappart, Pierre-Oliver, Gandarilla, Omar, Bose, Arindam, Sanchez-Gonzalez, Veronica, Rouse, Emily E., Lehoux, Sylvain D., Pandell, Nicole, Lim, Christine M., Clohessy, John G., Grossman, Joseph, Gonzalez, Raul, Del Pino, Sofia Perea, Daaboul, George, Sawhney, Mandeep S., Freedman, Steven D., Kleger, Alexander, Cummings, Richard D., Emili, Andrew, Muthuswamy, Lakshmi B., Hidalgo, Manuel, Muthuswamy, Senthil K.
Publicado 2020

Elevated levels of mitochondrial CoQ(10) induce ROS-mediated apoptosis in pancreatic cancer

por Dadali, Tulin, Diers, Anne R., Kazerounian, Shiva, Muthuswamy, Senthil K., Awate, Pallavi, Ng, Ryan, Mogre, Saie, Spencer, Carrie, Krumova, Katerina, Rockwell, Hannah E., McDaniel, Justice, Chen, Emily Y., Gao, Fei, Diedrich, Karl T., Vemulapalli, Vijetha, Rodrigues, Leonardo O., Akmaev, Viatcheslav R., Thapa, Khampaseuth, Hidalgo, Manuel, Bose, Arindam, Vishnudas, Vivek K., Moser, A. James, Granger, Elder, Kiebish, Michael A., Gesta, Stephane, Narain, Niven R., Sarangarajan, Rangaprasad
Publicado 2021

Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

por Dai, Xiangpeng, Gan, Wenjian, Li, Xiaoning, Wang, Shangqian, Zhang, Wei, Huang, Ling, Liu, Shengwu, Zhong, Qing, Guo, Jianping, Zhang, Jinfang, Chen, Ting, Shimizu, Kouhei, Beca, Francisco, Blattner, Mirjam, Vasudevan, Divya, Buckley, Dennis L., Qi, Jun, Buser, Lorenz, Liu, Pengda, Inuzuka, Hiroyuki, Beck, Andrew H., Wang, Liewei, Wild, Peter J., Garraway, Levi A., Rubin, Mark A., Barbieri, Christopher E., Wong, Kwok-Kin, Muthuswamy, Senthil K., Huang, Jiaoti, Chen, Yu, Bradner, James E., Wei, Wenyi
Publicado 2017