Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington’s disease

por Norrbacka, Susanna, Lindholm, Dan, Myöhänen, Timo T.
Publicado 2019

Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo

por Svarcbahs, Reinis, Julku, Ulrika H., Norrbacka, Susanna, Myöhänen, Timo T.
Publicado 2018

Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease

por Kilpeläinen, Tommi, Julku, Ulrika H., Svarcbahs, Reinis, Myöhänen, Timo T.
Publicado 2019

Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner

por Julku, Ulrika H., Jäntti, Maria, Svarcbahs, Reinis, Myöhänen, Timo T.
Publicado 2021

Catechol-O-Methyltransferase (COMT) Protein Expression and Activity after Dopaminergic and Noradrenergic Lesions of the Rat Brain

por Schendzielorz, Nadia, Oinas, Juha-Pekka, Myöhänen, Timo T., Reenilä, Ilkka, Raasmaja, Atso, Männistö, Pekka T.
Publicado 2013

Prolyl oligopeptidase inhibition reduces alpha‐synuclein aggregation in a cellular model of multiple system atrophy

por Cui, Hengjing, Kilpeläinen, Tommi, Zouzoula, Lydia, Auno, Samuli, Trontti, Kalevi, Kurvonen, Sampo, Norrbacka, Susanna, Hovatta, Iiris, Jensen, Poul Henning, Myöhänen, Timo T.
Publicado 2021

2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors

por Pätsi, Henri T., Kilpeläinen, Tommi P., Auno, Samuli, Dillemuth, Pyry M. J., Arja, Khaled, Lahtela-Kakkonen, Maija K., Myöhänen, Timo T., Wallén, Erik A. A.
Publicado 2021

Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson’s Disease

por Kilpeläinen, Tommi P., Pätsi, Henri T., Svarcbahs, Reinis, Julku, Ulrika H., Eteläinen, Tony S., Cui, Hengjing, Auno, Samuli, Sipari, Nina, Norrbacka, Susanna, Leino, Teppo O., Jäntti, Maria, Myöhänen, Timo T., Wallén, Erik A. A.
Publicado 2023

Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis

por Zuo, Yiqin, Chun, Bongkwon, Potthoff, Sebastian A., Kazi, Naj, Brolin, Tyler J., Orhan, Diclehan, Yang, Hai-Chun, Ma, Li-Jun, Kon, Valentina, Myöhänen, Timo, Rhaleb, Nour-Eddine, Carretero, Oscar A., Fogo, Agnes B.
Publicado 2013

Mice Deficient in Transmembrane Prostatic Acid Phosphatase Display Increased GABAergic Transmission and Neurological Alterations

por Nousiainen, Heidi O., Quintero, Ileana B., Myöhänen, Timo T., Voikar, Vootele, Mijatovic, Jelena, Segerstråle, Mikael, Herrala, Annakaisa M., Kulesskaya, Natalia, Pulkka, Anitta E., Kivinummi, Tanja, Abo-Ramadan, Usama, Taira, Tomi, Piepponen, T. Petteri, Rauvala, Heikki, Vihko, Pirkko
Publicado 2014