DNA Damage Stress and Inhibition of Jak2-V617F Cause Its Degradation and Synergistically Induce Apoptosis through Activation of GSK3β

por Nagao, Toshikage, Oshikawa, Gaku, Wu, Nan, Kurosu, Tetsuya, Miura, Osamu
Publicado 2011

PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells

por WU, NAN, KUROSU, TETSUYA, OSHIKAWA, GAKU, NAGAO, TOSHIKAGE, MIURA, OSAMU
Publicado 2012

Inhibition of the PI3K/Akt/GSK3 Pathway Downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD Downregulates DNA Damage-Induced Chk1 Activation as Well as G2/M Arrest and Prominently Enhan...

por Kurosu, Tetsuya, Nagao, Toshikage, Wu, Nan, Oshikawa, Gaku, Miura, Osamu
Publicado 2013

Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells

por Umezawa, Yoshihiro, Kurosu, Tetsuya, Akiyama, Hiroki, Wu, Nang, Nogami, Ayako, Nagao, Toshikage, Miura, Osamu
Publicado 2016

Acute myeloid leukemia with t(3;21)(q26.2;q22) developing following low-dose methotrexate therapy for rheumatoid arthritis and expressing two AML1/MDS1/EVI1 fusion proteins: A case...

por Tanaka, Keisuke, Oshikawa, Gaku, Akiyama, Hiroki, Ishida, Shinya, Nagao, Toshikage, Yamamoto, Masahide, Miura, Osamu
Publicado 2017

Proliferation and Survival Signaling from Both Jak2-V617F and Lyn Involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 Cell Line Newly Established from Acute Myeloid Leukemia Transformed...

por Nagao, Toshikage, Kurosu, Tetsuya, Umezawa, Yoshihiro, Nogami, Ayako, Oshikawa, Gaku, Tohda, Shuji, Yamamoto, Masahide, Miura, Osamu
Publicado 2014

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia

por Nogami, Ayako, Oshikawa, Gaku, Okada, Keigo, Fukutake, Shusaku, Umezawa, Yoshihiro, Nagao, Toshikage, Kurosu, Tetsuya, Miura, Osamu
Publicado 2015

Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including ne...

por Ishida, Shinya, Akiyama, Hiroki, Umezawa, Yoshihiro, Okada, Keigo, Nogami, Ayako, Oshikawa, Gaku, Nagao, Toshikage, Miura, Osamu
Publicado 2018

An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy

por Izumi, Yuta, Kanayama, Masashi, Shen, Zhongchuzi, Kai, Masayuki, Kawamura, Shunsuke, Akiyama, Megumi, Yamamoto, Masahide, Nagao, Toshikage, Okada, Keigo, Kawamata, Norihiko, Toyota, Shigeo, Ohteki, Toshiaki
Publicado 2021

Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis

por Aftabizadeh, Maryam, Li, Yi-Jia, Zhao, Qianqian, Zhang, Chunyan, Ambaye, Nigus, Song, Jieun, Nagao, Toshikage, Lahtz, Christoph, Fakih, Marwan, Ann, David K., Yu, Hua, Herrmann, Andreas
Publicado 2021

Lymphoproliferative disorder risk after methotrexate treatment for rheumatoid arthritis

por Tanaka, Keisuke, Ichikawa, Ayako, Umezawa, Natsuka, Yamamoto, Kouhei, Yoshifuji, Kota, Okada, Keigo, Nogami, Ayako, Umezawa, Yoshihiro, Nagao, Toshikage, Sakashita, Chizuko, Mori, Takehiko, Tohda, Shuji, Koike, Ryuji, Yasuda, Shinsuke, Yamamoto, Masahide
Publicado 2023