ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation

por Saika, Makoto, Inoue, Daichi, Nagase, Reina, Sato, Naru, Tsuchiya, Akiho, Yabushita, Tomohiro, Kitamura, Toshio, Goyama, Susumu
Publicado 2018

SETBP1 Mutations Drive Leukemic Transformation in ASXL1-Mutated MDS

por Inoue, Daichi, Kitaura, Jiro, Matsui, Hirotaka, Hou, Hsin-An, Chou, Wen-Chien, Nagamachi, Akiko, Kawabata, Kimihito Cojin, Togami, Katsuhiro, Nagase, Reina, Horikawa, Sayuri, Saika, Makoto, Micol, Jean-Baptiste, Hayashi, Yasutaka, Harada, Yuka, Harada, Hironori, Inaba, Toshiya, Tien, Hwei-Fang, Abdel-Wahab, Omar, Kitamura, Toshio
Publicado 2014

Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation

por Nagase, Reina, Inoue, Daichi, Pastore, Alessandro, Fujino, Takeshi, Hou, Hsin-An, Yamasaki, Norimasa, Goyama, Susumu, Saika, Makoto, Kanai, Akinori, Sera, Yasuyuki, Horikawa, Sayuri, Ota, Yasunori, Asada, Shuhei, Hayashi, Yasutaka, Kawabata, Kimihito Cojin, Takeda, Reina, Tien, Hwei-Fang, Honda, Hiroaki, Abdel-Wahab, Omar, Kitamura, Toshio
Publicado 2018

The molecular basis of myeloid malignancies

por KITAMURA, Toshio, INOUE, Daichi, OKOCHI-WATANABE, Naoko, KATO, Naoko, KOMENO, Yukiko, LU, Yang, ENOMOTO, Yutaka, DOKI, Noriko, UCHIDA, Tomoyuki, KAGIYAMA, Yuki, TOGAMI, Katsuhiro, KAWABATA, Kimihito C., NAGASE, Reina, HORIKAWA, Sayuri, HAYASHI, Yasutaka, SAIKA, Makoto, FUKUYAMA, Tomofusa, IZAWA, Kumi, OKI, Toshihiko, NAKAHARA, Fumio, KITAURA, Jiro
Publicado 2014

A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1

por Numata, Masashi, Haginoya, Noriyasu, Shiroishi, Machiko, Hirata, Tsuyoshi, Sato-Otsubo, Aiko, Yoshikawa, Kenji, Takata, Yoshimi, Nagase, Reina, Kashimoto, Yoshinori, Suzuki, Makoto, Schulte, Nina, Polier, Gernot, Kurimoto, Akiko, Tomoe, Yumiko, Toyota, Akiko, Yoneyama, Tomoko, Imai, Emi, Watanabe, Kenji, Hamada, Tomoaki, Kanada, Ryutaro, Watanabe, Jun, Kagoshima, Yoshiko, Tokumaru, Eri, Murata, Kenji, Baba, Takayuki, Shinozaki, Taeko, Ohtsuka, Masami, Goto, Koichi, Karibe, Tsuyoshi, Deguchi, Takao, Gocho, Yoshihiro, Yoshida, Masanori, Tomizawa, Daisuke, Kato, Motohiro, Tsutsumi, Shinji, Kitagawa, Mayumi, Abe, Yuki
Publicado 2023