Possibilities and challenges of small molecule organic compounds for the treatment of repeat diseases

por NAKATANI, Kazuhiko
Publicado 2022

A small-molecule fluorescence probe ANP77 for sensing RNA internal loop of C, U and A/CC motifs and their binding molecules

por Das, Bimolendu, Murata, Asako, Nakatani, Kazuhiko
Publicado 2021

Photoswitchable molecular glue for RNA: reversible photocontrol of structure and function of the ribozyme

por Dohno, Chikara, Kimura, Maki, Fujiwara, Yusuke, Nakatani, Kazuhiko
Publicado 2023

Naphthyridine tetramer with a pre-organized structure for 1:1 binding to a CGG/CGG sequence

por Dohno, Chikara, Kohyama, Izumi, Hong, Changfeng, Nakatani, Kazuhiko
Publicado 2012

Cyclic mismatch binding ligand CMBL4 binds to the 5′-T-3′/5′-GG-3′ site by inducing the flipping out of thymine base

por Mukherjee, Sanjukta, Dohno, Chikara, Asano, Kaori, Nakatani, Kazuhiko
Publicado 2016

Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes

por Bai, Li-Ping, Hagihara, Masaki, Nakatani, Kazuhiko, Jiang, Zhi-Hong
Publicado 2014

Small synthetic molecule-stabilized RNA pseudoknot as an activator for –1 ribosomal frameshifting

por Matsumoto, Saki, Caliskan, Neva, Rodnina, Marina V, Murata, Asako, Nakatani, Kazuhiko
Publicado 2018

The Dimeric Form of 1,3‐Diaminoisoquinoline Derivative Rescued the Mis‐splicing of Atp2a1 and Clcn1 Genes in Myotonic Dystrophy Type 1 Mouse Model

por Matsumoto, Jun, Nakamori, Masayuki, Okamoto, Tatsumasa, Murata, Asako, Dohno, Chikara, Nakatani, Kazuhiko
Publicado 2020

Premature translation termination mediated non-ER stress induced ATF6 activation by a ligand-dependent ribosomal frameshifting circuit

por Hsu, Hsiu-Ting, Murata, Asako, Dohno, Chikara, Nakatani, Kazuhiko, Chang, KungYao
Publicado 2022

NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA

por Yamada, Takeshi, Furuita, Kyoko, Sakurabayashi, Shuhei, Nomura, Makoto, Kojima, Chojiro, Nakatani, Kazuhiko
Publicado 2022

Method for Identifying Sequence Motifs in Pre-miRNAs for Small-Molecule Binding

por Takashima, Yusuke, Murata, Asako, Iida, Kei, Sugai, Ayako, Hagiwara, Masatoshi, Nakatani, Kazuhiko
Publicado 2022

HT-SELEX-based identification of binding pre-miRNA hairpin-motif for small molecules

por Mukherjee, Sanjukta, Murata, Asako, Ishida, Ryoga, Sugai, Ayako, Dohno, Chikara, Hamada, Michiaki, Krishna, Sudhir, Nakatani, Kazuhiko
Publicado 2021

Structural insights into synthetic ligands targeting A–A pairs in disease-related CAG RNA repeats

por Mukherjee, Sanjukta, Błaszczyk, Leszek, Rypniewski, Wojciech, Falschlunger, Christoph, Micura, Ronald, Murata, Asako, Dohno, Chikara, Nakatani, Kazuhiko, Kiliszek, Agnieszka
Publicado 2019

Small molecule targeting r(UGGAA)(n) disrupts RNA foci and alleviates disease phenotype in Drosophila model

por Shibata, Tomonori, Nagano, Konami, Ueyama, Morio, Ninomiya, Kensuke, Hirose, Tetsuro, Nagai, Yoshitaka, Ishikawa, Kinya, Kawai, Gota, Nakatani, Kazuhiko
Publicado 2021

Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer

por Simeth, Nadja A., Kobayashi, Shotaro, Kobauri, Piermichele, Crespi, Stefano, Szymanski, Wiktor, Nakatani, Kazuhiko, Dohno, Chikara, Feringa, Ben L.
Publicado 2021

Cyclic mismatch binding ligands interact with disease-associated CGG trinucleotide repeats in RNA and suppress their translation

por Konieczny, Patryk, Mukherjee, Sanjukta, Stepniak-Konieczna, Ewa, Taylor, Katarzyna, Niewiadomska, Daria, Piasecka, Agnieszka, Walczak, Agnieszka, Baud, Anna, Dohno, Chikara, Nakatani, Kazuhiko, Sobczak, Krzysztof
Publicado 2021

Development of 2, 7-Diamino-1, 8-Naphthyridine (DANP) Anchored Hairpin Primers for RT-PCR Detection of Chikungunya Virus Infection

por Chen, Huixin, Parimelalagan, Mariya, Takei, Fumie, Hapuarachchi, Hapuarachchige Chanditha, Koay, Evelyn Siew-Chuan, Ng, Lee Ching, Ho, Phui San, Nakatani, Kazuhiko, Chu, Justin Jang Hann
Publicado 2016

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD

por Fujino, Yuzo, Ueyama, Morio, Ishiguro, Taro, Ozawa, Daisaku, Ito, Hayato, Sugiki, Toshihiko, Murata, Asako, Ishiguro, Akira, Gendron, Tania, Mori, Kohji, Tokuda, Eiichi, Taminato, Tomoya, Konno, Takuya, Koyama, Akihide, Kawabe, Yuya, Takeuchi, Toshihide, Furukawa, Yoshiaki, Fujiwara, Toshimichi, Ikeda, Manabu, Mizuno, Toshiki, Mochizuki, Hideki, Mizusawa, Hidehiro, Wada, Keiji, Ishikawa, Kinya, Onodera, Osamu, Nakatani, Kazuhiko, Petrucelli, Leonard, Taguchi, Hideki, Nagai, Yoshitaka
Publicado 2023

Slipped-CAG DNA binding small molecule induces trinucleotide repeat contractions in vivo

por Nakamori, Masayuki, Panigrahi, Gagan B., Lanni, Stella, Gall-Duncan, Terence, Hayakawa, Hideki, Tanaka, Hana, Luo, Jennifer, Otabe, Takahiro, Li, Jinxing, Sakata, Akihiro, Caron, Marie-Christine, Joshi, Niraj, Prasolava, Tanya, Chiang, Karen, Masson, Jean-Yves, Wold, Marc S., Wang, Xiaoxiao, Lee, Marietta Y. W. T., Huddleston, John, Munson, Katherine M., Davidson, Scott, Layeghifard, Mehdi, Edward, Lisa-Monique, Gallon, Richard, Santibanez-Koref, Mauro, Murata, Asako, Takahashi, Masanori P., Eichler, Evan E., Shlien, Adam, Nakatani, Kazuhiko, Mochizuki, Hideki, Pearson, Christopher E.
Publicado 2020