Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

por Kumar, Varun, Qin, June, Jiang, Yongfeng, Duncan, Richard G, Brigham, Benjamin, Fishman, Shannon, Nair, Jayaprakash K, Akinc, Akin, Barros, Scott A, Kasperkovitz, Pia V
Publicado 2014

Generation and validation of structurally defined antibody–siRNA conjugates

por Nanna, Alex R, Kel’in, Alexander V, Theile, Christopher, Pierson, Justin M, Voo, Zhi Xiang, Garg, Ashish, Nair, Jayaprakash K, Maier, Martin A, Fitzgerald, Kevin, Rader, Christoph
Publicado 2020

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo

por Lee, Justin B, Zhang, Kaixin, Tam, Yuen Yi C, Quick, Joslyn, Tam, Ying K, Lin, Paulo JC, Chen, Sam, Liu, Yan, Nair, Jayaprakash K, Zlatev, Ivan, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Rennie, Paul S, Cullis, Pieter R
Publicado 2016

Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression

por Willoughby, Jennifer L.S., Chan, Amy, Sehgal, Alfica, Butler, James S., Nair, Jayaprakash K., Racie, Tim, Shulga-Morskaya, Svetlana, Nguyen, Tuyen, Qian, Kun, Yucius, Kristina, Charisse, Klaus, van Berkel, Theo J.C., Manoharan, Muthiah, Rajeev, Kallanthottathil G., Maier, Martin A., Jadhav, Vasant, Zimmermann, Tracy S.
Publicado 2018

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

por Nair, Jayaprakash K., Attarwala, Husain, Sehgal, Alfica, Wang, Qianfan, Aluri, Krishna, Zhang, Xuemei, Gao, Minggeng, Liu, Ju, Indrakanti, Ramesh, Schofield, Sally, Kretschmer, Philip, Brown, Christopher R., Gupta, Swati, Willoughby, Jennifer L.S., Boshar, Julie A., Jadhav, Vasant, Charisse, Klaus, Zimmermann, Tracy, Fitzgerald, Kevin, Manoharan, Muthiah, Rajeev, Kallanthottathil G., Akinc, Akin, Hutabarat, Renta, Maier, Martin A.
Publicado 2017

Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

por Brown, Christopher R, Gupta, Swati, Qin, June, Racie, Timothy, He, Guo, Lentini, Scott, Malone, Ryan, Yu, Mikyung, Matsuda, Shigeo, Shulga-Morskaya, Svetlana, Nair, Anil V, Theile, Christopher S, Schmidt, Karyn, Shahraz, Azar, Goel, Varun, Parmar, Rubina G, Zlatev, Ivan, Schlegel, Mark K, Nair, Jayaprakash K, Jayaraman, Muthusamy, Manoharan, Muthiah, Brown, Dennis, Maier, Martin A, Jadhav, Vasant
Publicado 2020