Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy

por Najem, Hinda, Khasraw, Mustafa, Heimberger, Amy B.
Publicado 2021

LMD-20. Immune Suppressive Macrophages and Signal Transducer and Activator of Transcription 3 (STAT3) Expression are common in Melanoma Leptomeningeal Disease

por Najem, Hinda, Marisetty, Anantha, Horbinski, Craig, Burks, Jared, Heimberger, Amy B
Publicado 2021

The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma

por Sooreshjani, Moloud, Tripathi, Shashwat, Dussold, Corey, Najem, Hinda, de Groot, John, Lukas, Rimas V., Heimberger, Amy B.
Publicado 2023

The Eclectic Nature of Glioma-Infiltrating Macrophages and Microglia

por Arrieta, Víctor A., Najem, Hinda, Petrosyan, Edgar, Lee-Chang, Catalina, Chen, Peiwen, Sonabend, Adam M., Heimberger, Amy B.
Publicado 2021

Immunobiology and Cytokine Modulation of the Pediatric Brain Tumor Microenvironment: A Scoping Review

por Budhiraja, Shreya, Najem, Hinda, Tripathi, Shashwat, Wadhawani, Nitin R., Horbinski, Craig, McCord, Matthew, Lenzen, Alicia C., Heimberger, Amy B., DeCuypere, Michael
Publicado 2023

Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma

por Boudreau, C. Elizabeth, Najem, Hinda, Ott, Martina, Horbinski, Craig, Fang, Dexing, DeRay, Chase M., Levine, Jonathan M., Curran, Michael A., Heimberger, Amy B.
Publicado 2021

Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era

por Larkin, Collin J., Arrieta, Víctor A., Najem, Hinda, Li, Gongbo, Zhang, Peng, Miska, Jason, Chen, Peiwen, James, Charles David, Sonabend, Adam M., Heimberger, Amy B.
Publicado 2022

cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma

por Tripathi, Shashwat, Najem, Hinda, Mahajan, Akanksha Sanjay, Zhang, Peng, Low, Justin T, Stegh, Alexander H, Curran, Michael A, Ashley, David M, James, Charles David, Heimberger, Amy B
Publicado 2022

A Case Study of Chimeric Antigen Receptor T Cell Function: Donor Therapeutic Differences in Activity and Modulation with Verteporfin

por Liang, Jiyong, Fang, Dexing, Gumin, Joy, Najem, Hinda, Sooreshjani, Moloud, Song, Renduo, Sabbagh, Aria, Kong, Ling-Yuan, Duffy, Joseph, Balyasnikova, Irina V., Pollack, Seth M., Puduvalli, Vinay K., Heimberger, Amy B.
Publicado 2023

Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous system

por Wei, Jun, Song, Renduo, Sabbagh, Aria, Marisetty, Anantha, Shukla, Neal, Fang, Dexing, Najem, Hinda, Ott, Martina, Long, James, Zhai, Lijie, Lesniak, Maciej S., James, Charles David, Platanias, Leonidas, Curran, Michael, Heimberger, Amy B.
Publicado 2022

Clinical Management of Supratentorial Non-Skull Base Meningiomas

por Adekanmbi, Adefisayo, Youngblood, Mark W., Karras, Constantine L., Oyetunji, Ephraim A., Kalapurakal, John, Horbinski, Craig M., Najem, Hinda, Hill, Virginia B., Chandler, James P., Heimberger, Amy B., Magill, Stephen T., Lukas, Rimas V.
Publicado 2022

Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution

por Lucas, Calixto-Hope, Mirchia, Kanish, Seo, Kyounghee, Najem, Hinda, Chen, William, Zakimi, Naomi, Choudhury, Abrar, Liu, S. John, Phillips, Joanna, Magill, Stephen, Horbinski, Craig, Solomon, David, Perry, Arie, Vasudevan, Harish, Heimberger, Amy, Raleigh, David
Publicado 2023

CD11c+CD163+ Cells and Signal Transducer and Activator of Transcription 3 (STAT3) Expression Are Common in Melanoma Leptomeningeal Disease

por Najem, Hinda, Marisetty, Anantha, Horbinski, Craig, Long, James, Huse, Jason T., Glitza Oliva, Isabella C., Ferguson, Sherise D., Kumthekar, Priya U., Wainwright, Derek A., Chen, Peiwen, Lesniak, Maciej S., Burks, Jared K., Heimberger, Amy B.
Publicado 2021

Macrophage–endothelial cell crosstalk orchestrates neutrophil recruitment in inflamed mucosa

por Ren, Xingsheng, Manzanares, Laura D., Piccolo, Enzo B., Urbanczyk, Jessica M., Sullivan, David P., Yalom, Lenore K., Bui, Triet M., Lantz, Connor, Najem, Hinda, Dulai, Parambir S., Heimberger, Amy B., Thorp, Edward B., Sumagin, Ronen
Publicado 2023

IMMU-10. PILOCYTIC ASTROCYTOMAS SHOW EVIDENCE OF INTRINSIC IMMUNE SURVEILLANCE AND ACTIVATION WITHIN THE TUMOR MICROENVIRONMENT

por Najem, Hinda, Tripathi, Shashwat, McCortney, Kathleen, Horak, Victoria Jane, Leonard, Kaethe, Steffens, Alicia, Walshon, Jordain, Horbinski, Craig M, Wadhwani, Nitin R, James, Charles David, Lam, Sandi, Lesniak, Maciej S, Burks, Jared K, Heimberger, Amy B, DeCuypere, Michael G
Publicado 2023

A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma

por de Groot, John, Ott, Martina, Wei, Jun, Kassab, Cynthia, Fang, Dexing, Najem, Hinda, O'Brien, Barbara, Weathers, Shiao-Pei, Matsouka, Carlos Kamiya, Majd, Nazanin K, Harrison, Rebecca A, Fuller, Gregory N, Huse, Jason T, Long, James P, Sawaya, Raymond, Rao, Ganesh, MacDonald, Tobey J, Priebe, Waldemar, DeCuypere, Michael, Heimberger, Amy B
Publicado 2022

NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy

por Choudhury, Abrar, Cady, Martha A., Lucas, Calixto-Hope G., Najem, Hinda, Phillips, Joanna J., Palikuqi, Brisa, Zakimi, Naomi, Joseph, Tara, Birrueta, Janeth Ochoa, Chen, William C., Bush, Nancy Ann Oberheim, Hervey-Jumper, Shawn L., Klein, Ophir D., Toedebusch, Christine M., Horbinski, Craig M., Magill, Stephen T., Bhaduri, Aparna, Perry, Arie, Dickinson, Peter J., Heimberger, Amy B., Ashworth, Alan, Crouch, Elizabeth E., Raleigh, David R.
Publicado 2023

Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expression

por Najem, Hinda, Ott, Martina, Kassab, Cynthia, Rao, Arvind, Rao, Ganesh, Marisetty, Anantha, Sonabend, Adam M., Horbinski, Craig, Verhaak, Roel, Shankar, Anand, Krishnan, Santhoshi N., Varn, Frederick S., Arrieta, Víctor A., Gupta, Pravesh, Ferguson, Sherise D., Huse, Jason T., Fuller, Gregory N., Long, James P., Winkowski, Daniel E., Freiberg, Ben A., James, Charles David, Platanias, Leonidas C., Lesniak, Maciej S., Burks, Jared K., Heimberger, Amy B.
Publicado 2022

Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas

por Youngblood, Mark W., Erson-Omay, Zeynep, Li, Chang, Najem, Hinda, Coșkun, Süleyman, Tyrtova, Evgeniya, Montejo, Julio D., Miyagishima, Danielle F., Barak, Tanyeri, Nishimura, Sayoko, Harmancı, Akdes Serin, Clark, Victoria E., Duran, Daniel, Huttner, Anita, Avşar, Timuçin, Bayri, Yasar, Schramm, Johannes, Boetto, Julien, Peyre, Matthieu, Riche, Maximilien, Goldbrunner, Roland, Amankulor, Nduka, Louvi, Angeliki, Bilgüvar, Kaya, Pamir, M. Necmettin, Özduman, Koray, Kilic, Türker, Knight, James R., Simon, Matthias, Horbinski, Craig, Kalamarides, Michel, Timmer, Marco, Heimberger, Amy B., Mishra-Gorur, Ketu, Moliterno, Jennifer, Yasuno, Katsuhito, Günel, Murat
Publicado 2023