Improvement of antibody affinity by introduction of basic amino acid residues into the framework region

por Fukunaga, Atsushi, Maeta, Shingo, Reema, Bajaj, Nakakido, Makoto, Tsumoto, Kouhei
Publicado 2018

Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain V(H)H antibodies

por Ikeuchi, Emina, Kuroda, Daisuke, Nakakido, Makoto, Murakami, Akikazu, Tsumoto, Kouhei
Publicado 2021

Development of a high-throughput method to screen novel antiviral materials

por Nakakido, Makoto, Tanaka, Naoki, Shimojo, Ayako, Miyamae, Nobuhiro, Tsumoto, Kouhei
Publicado 2022

Conformational features and interaction mechanisms of V(H)H antibodies with β‐hairpin CDR3: A case of Nb8‐HigB2 interaction

por Yamamoto, Koichi, Nagatoishi, Satoru, Matsunaga, Ryo, Nakakido, Makoto, Kuroda, Daisuke, Tsumoto, Kouhei
Publicado 2023

Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN()()

por Nakakido, Makoto, Deng, Zhenzhong, Suzuki, Takehiro, Dohmae, Naoshi, Nakamura, Yusuke, Hamamoto, Ryuji
Publicado 2015

PRMT6 increases cytoplasmic localization of p21(CDKN1A) in cancer cells through arginine methylation and makes more resistant to cytotoxic agents

por Nakakido, Makoto, Deng, Zhenzhong, Suzuki, Takehiro, Dohmae, Naoshi, Nakamura, Yusuke, Hamamoto, Ryuji
Publicado 2015

Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins

por Piao, Lianhua, Nakakido, Makoto, Suzuki, Takehiro, Dohmae, Naoshi, Nakamura, Yusuke, Hamamoto, Ryuji
Publicado 2016

Structure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations, using interaction analysis

por Chiba, Shuntaro, Tanabe, Aki, Nakakido, Makoto, Okuno, Yasushi, Tsumoto, Kouhei, Ohta, Masateru
Publicado 2020

Author Correction: Structure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations, using interaction analysis

por Chiba, Shuntaro, Tanabe, Aki, Nakakido, Makoto, Okuno, Yasushi, Tsumoto, Kouhei, Ohta, Masateru
Publicado 2021

Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene

por Yui, Anna, Kuroda, Daisuke, Maruno, Takahiro, Nakakido, Makoto, Nagatoishi, Satoru, Uchiyama, Susumu, Tsumoto, Kouhei
Publicado 2023

Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair

por Sone, Kenbun, Piao, Lianhua, Nakakido, Makoto, Ueda, Koji, Jenuwein, Thomas, Nakamura, Yusuke, Hamamoto, Ryuji
Publicado 2014

Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors

por Nakakido, Makoto, Tamura, Kenji, Chung, Suyoun, Ueda, Koji, Fujii, Risa, Kiyotani, Kazuma, Nakamura, Yusuke
Publicado 2016

Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3

por Kinoshita, Seisho, Nakakido, Makoto, Mori, Chinatsu, Kuroda, Daisuke, Caaveiro, Jose M.M., Tsumoto, Kouhei
Publicado 2022

Proteomic identification and validation of novel interactions of the putative tumor suppressor PRELP with membrane proteins including IGFI-R and p75NTR

por Kosuge, Hirofumi, Nakakido, Makoto, Nagatoishi, Satoru, Fukuda, Tetsuya, Bando, Yasuhiko, Ohnuma, Shin-ichi, Tsumoto, Kouhei
Publicado 2021

Arginine cluster introduction on framework region in anti‐lysozyme antibody improved association rate constant by changing conformational diversity of CDR loops

por Maeta, Shingo, Nakakido, Makoto, Matsuura, Hiroaki, Sakai, Naoki, Hirata, Kunio, Kuroda, Daisuke, Fukunaga, Atsushi, Tsumoto, Kouhei
Publicado 2023

Exploring designability of electrostatic complementarity at an antigen-antibody interface directed by mutagenesis, biophysical analysis, and molecular dynamics simulations

por Yoshida, Kouhei, Kuroda, Daisuke, Kiyoshi, Masato, Nakakido, Makoto, Nagatoishi, Satoru, Soga, Shinji, Shirai, Hiroki, Tsumoto, Kouhei
Publicado 2019

Targeting hemoglobin receptors IsdH and IsdB of Staphylococcus aureus with a single VHH antibody inhibits bacterial growth

por Valenciano-Bellido, Sandra, Caaveiro, Jose M.M., Nakakido, Makoto, Kuroda, Daisuke, Aikawa, Chihiro, Nakagawa, Ichiro, Tsumoto, Kouhei
Publicado 2023

Structure and role of the linker domain of the iron surface-determinant protein IsdH in heme transportation in Staphylococcus aureus

por Valenciano-Bellido, Sandra, Caaveiro, Jose M.M., Morante, Koldo, Sushko, Tatyana, Nakakido, Makoto, Nagatoishi, Satoru, Tsumoto, Kouhei
Publicado 2022

Ligand Installation to Polymeric Micelles for Pediatric Brain Tumor Targeting

por Watanabe, Takayoshi, Mizuno, Hayato Laurence, Norimatsu, Jumpei, Obara, Takumi, Cabral, Horacio, Tsumoto, Kouhei, Nakakido, Makoto, Kawauchi, Daisuke, Anraku, Yasutaka
Publicado 2023

PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP

por Deng, Xiaolan, Von Keudell, Gottfried, Suzuki, Takehiro, Dohmae, Naoshi, Nakakido, Makoto, Piao, Lianhua, Yoshioka, Yuichiro, Nakamura, Yusuke, Hamamoto, Ryuji
Publicado 2015