Insulin amyloid fibrils interact directly with the NLRP3, resulting in inflammasome activation and pyroptotic cell death

por Mori, Wakako, Kaneko, Naoe, Nakanishi, Ayaka, Zako, Tamotsu, Masumoto, Junya
Publicado 2021

IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation

por Morikawa, Shinnosuke, Kaneko, Naoe, Okumura, Chikara, Taguchi, Haruka, Kurata, Mie, Yamamoto, Toshihiro, Osawa, Haruhiko, Nakanishi, Ayaka, Zako, Tamotsu, Masumoto, Junya
Publicado 2018

Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

por Nakanishi, Ayaka, Kaneko, Naoe, Takeda, Hiroyuki, Sawasaki, Tatsuya, Morikawa, Shinnosuke, Zhou, Wei, Kurata, Mie, Yamamoto, Toshihiro, Akbar, Sheikh Mohammad Fazle, Zako, Tamotsu, Masumoto, Junya
Publicado 2018