Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function

por Kowalczyk, Dominika, Nakasone, Mark A, Smith, Brian O, Huang, Danny T
Publicado 2022

Structure of UBE2K–Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension

por Nakasone, Mark A., Majorek, Karolina A., Gabrielsen, Mads, Sibbet, Gary J., Smith, Brian O., Huang, Danny T.
Publicado 2022

A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants

por Gabrielsen, Mads, Buetow, Lori, Nakasone, Mark A., Ahmed, Syed Feroj, Sibbet, Gary J., Smith, Brian O., Zhang, Wei, Sidhu, Sachdev S., Huang, Danny T.
Publicado 2017

Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases

por Chatrin, Chatrin, Gabrielsen, Mads, Buetow, Lori, Nakasone, Mark A., Ahmed, Syed F., Sumpton, David, Sibbet, Gary J., Smith, Brian O., Huang, Danny T.
Publicado 2020

Extended ubiquitin species are protein-based DUB inhibitors

por Krutauz, Daria, Reis, Noa, Nakasone, Mark A., Siman, Peter, Zhang, Daoning, Kirkpatrick, Donald S., Gygi, Steven P., Brik, Ashraf, Fushman, David, Glickman, Michael H.
Publicado 2014

Base-CP proteasome can serve as a platform for stepwise lid formation

por Yu, Zanlin, Livnat-Levanon, Nurit, Kleifeld, Oded, Mansour, Wissam, Nakasone, Mark A., Castaneda, Carlos A., Dixon, Emma K., Fushman, David, Reis, Noa, Pick, Elah, Glickman, Michael H.
Publicado 2015

Hepatic glutamine synthetase controls N(5)-methylglutamine in homeostasis and cancer

por Villar, Victor H., Allega, Maria Francesca, Deshmukh, Ruhi, Ackermann, Tobias, Nakasone, Mark A., Vande Voorde, Johan, Drake, Thomas M., Oetjen, Janina, Bloom, Algernon, Nixon, Colin, Müller, Miryam, May, Stephanie, Tan, Ee Hong, Vereecke, Lars, Jans, Maude, Blancke, Gillian, Murphy, Daniel J., Huang, Danny T., Lewis, David Y., Bird, Thomas G., Sansom, Owen J., Blyth, Karen, Sumpton, David, Tardito, Saverio
Publicado 2022