Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice

por Namas, Rami A., Bartels, John, Hoffman, Rosemary, Barclay, Derek, Billiar, Timothy R., Zamora, Ruben, Vodovotz, Yoram
Publicado 2013

Unsupervised Clustering Analysis Based on MODS Severity Identifies Four Distinct Organ Dysfunction Patterns in Severely Injured Blunt Trauma Patients

por Liu, Dongmei, Namas, Rami A., Vodovotz, Yoram, Peitzman, Andrew B., Simmons, Richard L., Yuan, Hong, Mi, Qi, Billiar, Timothy R.
Publicado 2020

The independent prognostic value of global epigenetic alterations: An analysis of single-cell ATAC-seq of circulating leukocytes from trauma patients followed by validation in whol...

por Chen, Tianmeng, Conroy, Julia, Wang, Xinjun, Situ, Michelle, Namas, Rami A., Vodovotz, Yoram, Chen, Wei, Singh, Harinder, Billiar, Timothy R.
Publicado 2022

Protective/reparative cytokines are suppressed at high injury severity in human trauma

por Cai, Jinman, McKinley, Todd, Billiar, Isabel, Zenati, Mazen S, Gaski, Greg, Vodovotz, Yoram, Gruen, Danielle S, Billiar, Timothy R, Namas, Rami A
Publicado 2021

Central Role for MCP-1/CCL2 in Injury-Induced Inflammation Revealed by In Vitro, In Silico, and Clinical Studies

por Ziraldo, Cordelia, Vodovotz, Yoram, Namas, Rami A., Almahmoud, Khalid, Tapias, Victor, Mi, Qi, Barclay, Derek, Jefferson, Bahiyyah S., Chen, Guoqiang, Billiar, Timothy R., Zamora, Ruben
Publicado 2013

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model

por Xu, Jing, Guardado, Jesse, Hoffman, Rosemary, Xu, Hui, Namas, Rami, Vodovotz, Yoram, Xu, Li, Ramadan, Mostafa, Brown, Joshua, Turnquist, Heth R., Billiar, Timothy R.
Publicado 2017

MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes

por Schimunek, Lukas, Namas, Rami A., Yin, Jinling, Barclay, Derek, Liu, Dongmei, el-Dehaibi, Fayten, Abboud, Andrew, Cohen, Maria, Zamora, Ruben, Billiar, Timothy R., Vodovotz, Yoram
Publicado 2019

Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma

por Zaaqoq, Akram M., Namas, Rami A., Abdul-Malak, Othman, Almahmoud, Khalid, Barclay, Derek, Yin, Jinling, Zamora, Ruben, Rosengart, Matthew R., Billiar, Timothy R., Vodovotz, Yoram
Publicado 2019

Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients

por Abdul-Malak, Othman, Vodovotz, Yoram, Zaaqoq, Akram, Guardado, Jesse, Almahmoud, Khalid, Yin, Jinling, Zuckerbraun, Brian, Peitzman, Andrew B., Sperry, Jason, Billiar, Timothy R., Namas, Rami A.
Publicado 2016

“Thinking” vs. “Talking”: Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress

por Vodovotz, Yoram, Simmons, Richard L., Gandhi, Chandrashekhar R., Barclay, Derek, Jefferson, Bahiyyah S., Huang, Chao, Namas, Rami, el-Dehaibi, Fayten, Mi, Qi, Billiar, Timothy R., Zamora, Ruben
Publicado 2017

Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines...

por Bonaroti, Jillian, Billiar, Isabel, Moheimani, Hamed, Wu, Junru, Namas, Rami, Li, Shimena, Kar, Upendra K., Vodovotz, Yoram, Neal, Matthew D., Sperry, Jason L., Billiar, Timothy R.
Publicado 2022

Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes

por Schimunek, Lukas, Lindberg, Haley, Cohen, Maria, Namas, Rami A., Mi, Qi, Yin, Jinling, Barclay, Derek, El-Dehaibi, Fayten, Abboud, Andrew, Zamora, Ruben, Billiar, Timothy Robert, Vodovotz, Yoram
Publicado 2021

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries

por Almahmoud, Khalid, Abboud, Andrew, Namas, Rami A., Zamora, Ruben, Sperry, Jason, Peitzman, Andrew B., Truitt, Michael S., Gaski, Greg E., McKinley, Todd O., Billiar, Timothy R., Vodovotz, Yoram
Publicado 2019

Insights into the association between coagulopathy and inflammation: abnormal clot mechanics are a warning of immunologic dysregulation following major injury

por Savage, Stephanie A., Zarzaur, Ben L., Gaski, Greg E., McCarroll, Tyler, Zamora, Ruben, Namas, Rami A., Vodovotz, Yoram, Callcut, Rachael A., Billiar, Timothy R., McKinley, Todd O.
Publicado 2020

A putative “chemokine switch” that regulates systemic acute inflammation in humans

por Azhar, Nabil, Namas, Rami A., Almahmoud, Khalid, Zaaqoq, Akram, Malak, Othman A., Barclay, Derek, Yin, Jinling, El-Dehaibi, Fayten, Abboud, Andrew, Simmons, Richard L., Zamora, Ruben, Billiar, Timothy R., Vodovotz, Yoram
Publicado 2021

A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes

por El-Dehaibi, Fayten, Zamora, Ruben, Radder, Josiah, Yin, Jinling, Shah, Ashti M., Namas, Rami A., Situ, Michelle, Zhao, Yanwu, Bain, William, Morris, Alison, McVerry, Bryan J., Barclay, Derek A., Billiar, Timothy R., Zhang, Yingze, Kitsios, Georgios D., Vodovotz, Yoram
Publicado 2023

A road map from single-cell transcriptome to patient classification for the immune response to trauma

por Chen, Tianmeng, Delano, Matthew J., Chen, Kong, Sperry, Jason L., Namas, Rami A., Lamparello, Ashley J., Deng, Meihong, Conroy, Julia, Moldawer, Lyle L., Efron, Philip A., Loughran, Patricia, Seymour, Christopher, Angus, Derek C., Vodovotz, Yoram, Chen, Wei, Billiar, Timothy R.
Publicado 2021

Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness

por Wu, Junru, Cyr, Anthony, Gruen, Danielle S., Lovelace, Tyler C., Benos, Panayiotis V., Chen, Tianmeng, Guyette, Francis X., Yazer, Mark H., Daley, Brian J., Miller, Richard S., Harbrecht, Brian G., Claridge, Jeffrey A., Phelan, Herb A., Zuckerbraun, Brian S., Neal, Matthew D., Johansson, Pär I., Stensballe, Jakob, Namas, Rami A., Vodovotz, Yoram, Sperry, Jason L., Billiar, Timothy R.
Publicado 2021

Lipidomic signatures align with inflammatory patterns and outcomes in critical illness

por Wu, Junru, Cyr, Anthony, Gruen, Danielle S., Lovelace, Tyler C., Benos, Panayiotis V., Das, Jishnu, Kar, Upendra K., Chen, Tianmeng, Guyette, Francis X., Yazer, Mark H., Daley, Brian J., Miller, Richard S., Harbrecht, Brian G., Claridge, Jeffrey A., Phelan, Herb A., Zuckerbraun, Brian S., Neal, Matthew D., Johansson, Pär I., Stensballe, Jakob, Namas, Rami A., Vodovotz, Yoram, Sperry, Jason L., Billiar, Timothy R.
Publicado 2022

Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses

por Wu, Junru, Vodovotz, Yoram, Abdelhamid, Sultan, Guyette, Francis X., Yaffe, Michael B., Gruen, Danielle S., Cyr, Anthony, Okonkwo, David O., Kar, Upendra K., Krishnamoorthi, Neha, Voinchet, Robert G., Billiar, Isabel M., Yazer, Mark H., Namas, Rami A., Daley, Brian J., Miller, Richard S., Harbrecht, Brian G., Claridge, Jeffrey A., Phelan, Herbert A., Zuckerbraun, Brian S., Johansson, Pär I., Stensballe, Jakob, Morrissey, James H., Tracy, Russell P., Wisniewski, Stephen R., Neal, Matthew D., Sperry, Jason L., Billiar, Timothy R.
Publicado 2021