A review of clinical efficacy data supporting emergency use authorization for COVID‐19 therapeutics and lessons for future pandemics

por Yoo, Seo‐Hyun, Kim, Lauren, Lu, Michelle, Nagoshi, Kira, Namchuk, Mark N.
Publicado 2022

In vivo Characterization of the Opioid Receptor–Binding Profiles of Samidorphan and Naltrexone in Rats: Comparisons at Clinically Relevant Concentrations

por Tan, Laura A, Gajipara, Nileshkumar, Sun, Lei, Bacolod, Maria, Zhou, Ying, Namchuk, Mark, Cunningham, Jacobi I
Publicado 2022

Samidorphan mitigates olanzapine-induced weight gain and metabolic dysfunction in rats and non-human primates

por Cunningham, Jacobi I, Eyerman, David J, Todtenkopf, Mark S, Dean, Reginald L, Deaver, Daniel R, Sanchez, Connie, Namchuk, Mark
Publicado 2019

Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteers

por Toledo, Frederico G. S., Martin, William F., Morrow, Linda, Beysen, Carine, Bajorunas, Daiva, Jiang, Ying, Silverman, Bernard L., McDonnell, David, Namchuk, Mark N., Newcomer, John W., Graham, Christine
Publicado 2021

Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization

por Patten, J.J., Keiser, Patrick T., Morselli-Gysi, Deisy, Menichetti, Giulia, Mori, Hiroyuki, Donahue, Callie J., Gan, Xiao, Valle, Italo do, Geoghegan-Barek, Kathleen, Anantpadma, Manu, Boytz, RuthMabel, Berrigan, Jacob L., Stubbs, Sarah H., Ayazika, Tess, O’Leary, Colin, Jalloh, Sallieu, Wagner, Florence, Ayehunie, Seyoum, Elledge, Stephen J., Anderson, Deborah, Loscalzo, Joseph, Zitnik, Marinka, Gummuluru, Suryaram, Namchuk, Mark N., Barabási, Albert-László, Davey, Robert A.
Publicado 2022

A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening

por Gorgulla, Christoph, Padmanabha Das, Krishna M., Leigh, Kendra E., Cespugli, Marco, Fischer, Patrick D., Wang, Zi-Fu, Tesseyre, Guilhem, Pandita, Shreya, Shnapir, Alec, Calderaio, Anthony, Gechev, Minko, Rose, Alexander, Lewis, Noam, Hutcheson, Colin, Yaffe, Erez, Luxenburg, Roni, Herce, Henry D., Durmaz, Vedat, Halazonetis, Thanos D., Fackeldey, Konstantin, Patten, Justin J., Chuprina, Alexander, Dziuba, Igor, Plekhova, Alla, Moroz, Yurii, Radchenko, Dmytro, Tarkhanova, Olga, Yavnyuk, Irina, Gruber, Christian, Yust, Ryan, Payne, Dave, Näär, Anders M., Namchuk, Mark N., Davey, Robert A., Wagner, Gerhard, Kinney, Jamie, Arthanari, Haribabu
Publicado 2020

A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening

por Gorgulla, Christoph, Padmanabha Das, Krishna M., Leigh, Kendra E., Cespugli, Marco, Fischer, Patrick D., Wang, Zi-Fu, Tesseyre, Guilhem, Pandita, Shreya, Shnapir, Alec, Calderaio, Anthony, Gechev, Minko, Rose, Alexander, Lewis, Noam, Hutcheson, Colin, Yaffe, Erez, Luxenburg, Roni, Herce, Henry D., Durmaz, Vedat, Halazonetis, Thanos D., Fackeldey, Konstantin, Patten, J.J., Chuprina, Alexander, Dziuba, Igor, Plekhova, Alla, Moroz, Yurii, Radchenko, Dmytro, Tarkhanova, Olga, Yavnyuk, Irina, Gruber, Christian, Yust, Ryan, Payne, Dave, Näär, Anders M., Namchuk, Mark N., Davey, Robert A., Wagner, Gerhard, Kinney, Jamie, Arthanari, Haribabu
Publicado 2021

An open toolkit for tracking open science partnership implementation and impact

por Gold, E. Richard, Ali-Khan, Sarah E., Allen, Liz, Ballell, Lluis, Barral-Netto, Manoel, Carr, David, Chalaud, Damien, Chaplin, Simon, Clancy, Matthew S., Clarke, Patricia, Cook-Deegan, Robert, Dinsmore, A. P., Doerr, Megan, Federer, Lisa, Hill, Steven A., Jacobs, Neil, Jean, Antoine, Jefferson, Osmat Azzam, Jones, Chonnettia, Kahl, Linda J., Kariuki, Thomas M., Kassel, Sophie N., Kiley, Robert, Kittrie, Elizabeth Robboy, Kramer, Bianca, Lee, Wen Hwa, MacDonald, Emily, Mangravite, Lara M., Marincola, Elizabeth, Mietchen, Daniel, Molloy, Jennifer C., Namchuk, Mark, Nosek, Brian A., Paquet, Sébastien, Pirmez, Claude, Seyller, Annabel, Skingle, Malcolm, Spadotto, S. Nicole, Staniszewska, Sophie, Thelwall, Mike
Publicado 2019