The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer

por He, Ting, Gao, Yinglei, Fang, Yanfen, Zhang, Yangming, Zhang, Shuwei, Nan, Fajun, Ding, Jian, Chen, Yi
Publicado 2022

Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis

por Cui, Jin, Wang, Xiaoyin, Li, Xiaohang, Wang, Xin, Zhang, Chenlu, Li, Wei, Zhang, Yangming, Gu, Haifeng, Xie, Xin, Nan, Fajun, Zhao, Jian, Pei, Gang
Publicado 2015

ψ-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling

por Ding, Jin, Wen, Wen, Xiang, Daimin, Yin, Peipei, Liu, Yanfang, Liu, Chang, He, Guoping, Cheng, Zhuo, Yin, Jianpeng, Sheng, Chunquan, Zhang, Wen, Nan, Fajun, Ye, Wencai, Zhang, Xiuli, Wang, Hongyang
Publicado 2015

One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation

por Li, Jian, Chen, Jing, Zhang, Li, Wang, Feng, Gui, Chunshan, Zhang, Li, Qin, Yu, Xu, Qiang, Liu, Hong, Nan, Fajun, Shen, Jingkang, Bai, Donglu, Chen, Kaixian, Shen, Xu, Jiang, Hualiang
Publicado 2006

Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia

por Xie, Zhifu, Zhang, Mei, Song, Qian, Cheng, Long, Zhang, Xinwen, Song, Gaolei, Sun, Xinyu, Gu, Min, Zhou, Chendong, Zhang, Yangming, Zhu, Kexin, Yin, Jianpeng, Chen, Xiaoyan, Li, Jingya, Nan, Fajun
Publicado 2023

Ligand activation mechanisms of human KCNQ2 channel

por Ma, Demin, Zheng, Yueming, Li, Xiaoxiao, Zhou, Xiaoyu, Yang, Zhenni, Zhang, Yan, Wang, Long, Zhang, Wenbo, Fang, Jiajia, Zhao, Guohua, Hou, Panpan, Nan, Fajun, Yang, Wei, Su, Nannan, Gao, Zhaobing, Guo, Jiangtao
Publicado 2023