Special Issue: “James D. McChesney, Vision, Passion and Leadership in the Development of Plant-Derived Natural Products”

por Walker, Larry A., Nanayakkara, N. P. Dhammika
Publicado 2021

Novel Bioassay for the Discovery of Inhibitors of the 2-C-Methyl-D-erythritol 4-Phosphate (MEP) and Terpenoid Pathways Leading to Carotenoid Biosynthesis

por Corniani, Natália, Velini, Edivaldo D., Silva, Ferdinando M. L., Nanayakkara, N. P. Dhammika, Witschel, Matthias, Dayan, Franck E.
Publicado 2014

Enantioselective Interactions of Anti-Infective 8-Aminoquinoline Therapeutics with Human Monoamine Oxidases A and B †

por Chaurasiya, Narayan D., Liu, Haining, Doerksen, Robert J., Nanayakkara, N. P. Dhammika, Walker, Larry A., Tekwani, Babu L.
Publicado 2021

Hydroxylated Derivatives of NPC1161: Theoretical Insights into Their Potential Toxicity and the Feasibility and Regioselectivity of Their Formation

por Ding, Yuanqing, Liu, Haining, Nanayakkara, N. P. Dhammika, Khan, Ikhlas A., Tekwani, Babu L., Walker, Larry A., Doerksen, Robert J.
Publicado 2014

Pathway-specific inhibition of primaquine metabolism by chloroquine/quinine

por Fasinu, Pius S., Tekwani, Babu L., Avula, Bharathi, Chaurasiya, Narayan D., Nanayakkara, N. P. Dhammika, Wang, Yan-Hong, Khan, Ikhlas A., Walker, Larry A.
Publicado 2016

Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, Isolated from a Diseased Torreya taxifolia Leaf

por Kumarihamy, Mallika, Ferreira, Daneel, Croom, Edward M., Sahu, Rajnish, Tekwani, Babu L., Duke, Stephen O., Khan, Shabana, Techen, Natascha, Nanayakkara, N. P. Dhammika
Publicado 2019

NPC1161B, an 8-Aminoquinoline Analog, Is Metabolized in the Mosquito and Inhibits Plasmodium falciparum Oocyst Maturation

por Hamerly, Timothy, Tweedell, Rebecca E., Hritzo, Bernadette, Nyasembe, Vincent O., Tekwani, Babu L., Nanayakkara, N. P. Dhammika, Walker, Larry A., Dinglasan, Rhoel R.
Publicado 2019

Antimalarials and Phytotoxins from Botryosphaeria dothidea Identified from a Seed of Diseased Torreya taxifolia

por Kumarihamy, Mallika, Rosa, Luiz H., Techen, Natascha, Ferreira, Daneel, Croom, Edward M., Duke, Stephen O., Tekwani, Babu L., Khan, Shabana, Nanayakkara, N. P. Dhammika
Publicado 2020

Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes

por Fasinu, Pius S., Nanayakkara, N. P. Dhammika, Wang, Yan-Hong, Chaurasiya, Narayan D., Herath, H. M. Bandara, McChesney, James D., Avula, Bharathi, Khan, Ikhlas, Tekwani, Babu L., Walker, Larry A.
Publicado 2019

A cytochrome P450 CYP71 enzyme expressed in Sorghum bicolor root hair cells participates in the biosynthesis of the benzoquinone allelochemical sorgoleone

por Pan, Zhiqiang, Baerson, Scott R., Wang, Mei, Bajsa‐Hirschel, Joanna, Rimando, Agnes M., Wang, Xiaoqiang, Nanayakkara, N. P. Dhammika, Noonan, Brice P., Fromm, Michael E., Dayan, Franck E., Khan, Ikhlas A., Duke, Stephen O.
Publicado 2018

Synthesis and Inhibitory Activity of Machaeridiol-Based Novel Anti-MRSA and Anti-VRE Compounds and Their Profiling for Cancer-Related Signaling Pathways

por Kumarihamy, Mallika, Tripathi, Siddharth, Balachandran, Premalatha, Avula, Bharathi, Zhao, Jianping, Wang, Mei, Bennett, Maria M., Zhang, Jin, Carr, Mary A., Lovell, K. Michael, Wellington, Ocean I., Marquart, Mary E., Nanayakkara, N. P. Dhammika, Muhammad, Ilias
Publicado 2022

Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes

por Fasinu, Pius S., Avula, Bharathi, Tekwani, Babu L., Nanayakkara, N. P. Dhammika, Wang, Yan-Hong, Bandara Herath, H. M. T., McChesney, James D., Reichard, Gregory A., Marcsisin, Sean R., Elsohly, Mahmoud A., Khan, Shabana I., Khan, Ikhlas A., Walker, Larry A.
Publicado 2016

Comparative metabolism and tolerability of racemic primaquine and its enantiomers in human volunteers during 7-day administration

por Khan, Washim, Wang, Yan-Hong, Chaurasiya, Narayan D., Nanayakkara, N. P. Dhammika, Bandara Herath, H. M., Harrison, Kerri A., Dale, Gray, Stanford, Donald A., Dahl, Eric P., McChesney, James D., Gul, Waseem, ElSohly, Mahmoud A., Jollow, David, Tekwani, Babu L., Walker, Larry A.
Publicado 2023

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

por Marcsisin, Sean R, Sousa, Jason C, Reichard, Gregory A, Caridha, Diana, Zeng, Qiang, Roncal, Norma, McNulty, Ronan, Careagabarja, Julio, Sciotti, Richard J, Bennett, Jason W, Zottig, Victor E, Deye, Gregory, Li, Qigui, Read, Lisa, Hickman, Mark, Nanayakkara, N P Dhammika, Walker, Larry A, Smith, Bryan, Melendez, Victor, Pybus, Brandon S
Publicado 2014