Safety, tolerability, and pharmacokinetics of single and repeat ascending doses of CHF6001, a novel inhaled phosphodiesterase-4 inhibitor: two randomized trials in healthy voluntee...

por Mariotti, Fabrizia, Govoni, Mirco, Lucci, Germano, Santoro, Debora, Nandeuil, Marie Anna
Publicado 2018

Dose–response of an extrafine dry powder inhaler formulation of glycopyrronium bromide: randomized, double-blind, placebo-controlled, dose-ranging study (GlycoNEXT)

por Beeh, Kai M, Emirova, Aida, Prunier, Hélène, Santoro, Debora, Nandeuil, Marie Anna
Publicado 2018

Efficacy and safety of CHF6001, a novel inhaled PDE4 inhibitor in COPD: the PIONEER study

por Singh, Dave, Emirova, Aida, Francisco, Catherine, Santoro, Debora, Govoni, Mirco, Nandeuil, Marie Anna
Publicado 2020

Concentration–QT Modeling Following Inhalation of the Novel Inhaled Phosphodiesterase‐4 Inhibitor CHF6001 in Healthy Volunteers Shows an Absence of QT Prolongation

por Jolling, Koen, Äbelö, Angela, Luyckx, Nicolas, Nandeuil, Marie‐Anna, Govoni, Mirco, Cella, Massimo, Lindauer, Andreas
Publicado 2019

Effect of the inhaled PDE4 inhibitor CHF6001 on biomarkers of inflammation in COPD

por Singh, Dave, Beeh, Kai Michael, Colgan, Brendan, Kornmann, Oliver, Leaker, Brian, Watz, Henrik, Lucci, Germano, Geraci, Silvia, Emirova, Aida, Govoni, Mirco, Nandeuil, Marie Anna
Publicado 2019

COPD sputum eosinophils: relationship to blood eosinophils and the effect of inhaled PDE4 inhibition

por Singh, Dave, Watz, Henrik, Beeh, Kai Michael, Kornmann, Oliver, Leaker, Brian, Colgan, Brendan, Lucci, Germano, Emirova, Aida, Nandeuil, Marie Anna, Santoro, Debora, Balzano, Deborah, Govoni, Mirco
Publicado 2020

Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis

por Govoni, Mirco, Bassi, Michele, Vezzoli, Stefano, Lucci, Germano, Emirova, Aida, Nandeuil, Marie Anna, Petruzzelli, Stefano, Jellema, Gera L., Afolabi, Ebenezer K., Colgan, Brendan, Leaker, Brian, Kornmann, Oliver, Beeh, Kai Michael, Watz, Henrik, Singh, Dave
Publicado 2020