Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase

por Vijayakumar, Sapna, Liu, Guizhong, Wen, Huei-Chi, Abu, Yaa, Chong, Robert, Nastri, Horacio, Bornstein, Gadi G., Pan, Zhen-Qiang, Aaronson, Stuart A.
Publicado 2017

A single donor is sufficient to produce a highly functional in vitro antibody library

por Erasmus, M. Frank, D’Angelo, Sara, Ferrara, Fortunato, Naranjo, Leslie, Teixeira, André A., Buonpane, Rebecca, Stewart, Shaun M., Nastri, Horacio G., Bradbury, Andrew R. M.
Publicado 2021

Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs

por Teixeira, Andre A. R., D’Angelo, Sara, Erasmus, M. Frank, Leal-Lopes, Camila, Ferrara, Fortunato, Spector, Laura P., Naranjo, Leslie, Molina, Esteban, Max, Tamara, DeAguero, Ashley, Perea, Katherine, Stewart, Shaun, Buonpane, Rebecca A., Nastri, Horacio G., Bradbury, Andrew R. M.
Publicado 2022

A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade

por Geuijen, Cecile, Tacken, Paul, Wang, Liang-Chuan, Klooster, Rinse, van Loo, Pieter Fokko, Zhou, Jing, Mondal, Arpita, Liu, Yao-bin, Kramer, Arjen, Condamine, Thomas, Volgina, Alla, Hendriks, Linda J. A., van der Maaden, Hans, Rovers, Eric, Engels, Steef, Fransen, Floris, den Blanken-Smit, Renate, Zondag-van der Zande, Vanessa, Basmeleh, Abdul, Bartelink, Willem, Kulkarni, Ashwini, Marissen, Wilfred, Huang, Cheng-Yen, Hall, Leslie, Harvey, Shane, Kim, Soyeon, Martinez, Marina, O’Brien, Shaun, Moon, Edmund, Albelda, Steven, Kanellopoulou, Chrysi, Stewart, Shaun, Nastri, Horacio, Bakker, Alexander B. H., Scherle, Peggy, Logtenberg, Ton, Hollis, Gregory, de Kruif, John, Huber, Reid, Mayes, Patrick A., Throsby, Mark
Publicado 2021