Gene Expression Profile as a Predictor of Seizure Liability

por Lipponen, Anssi, Kajevu, Natallie, Natunen, Teemu, Ciszek, Robert, Puhakka, Noora, Hiltunen, Mikko, Pitkänen, Asla
Publicado 2023

C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner

por Leskelä, Stina, Huber, Nadine, Rostalski, Hannah, Natunen, Teemu, Remes, Anne M., Takalo, Mari, Hiltunen, Mikko, Haapasalo, Annakaisa
Publicado 2019

Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology

por Kajevu, Natallie, Lipponen, Anssi, Andrade, Pedro, Bañuelos, Ivette, Puhakka, Noora, Hämäläinen, Elina, Natunen, Teemu, Hiltunen, Mikko, Pitkänen, Asla
Publicado 2023

Regulation of key proteins in Alzheimer’s disease molecular pathogenesis by ubiquilin-1

por Takalo, Mari, Viswanathan, Jayashree, Natunen, Teemu, Kurkinen, Kaisa MA, Tanila, Heikki, Soininen, Hilkka, Tanzi, Rudolph E, Hiltunen, Mikko, Haapasalo, Annakaisa
Publicado 2013

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease

por Marttinen, Mikael, Takalo, Mari, Natunen, Teemu, Wittrahm, Rebekka, Gabbouj, Sami, Kemppainen, Susanna, Leinonen, Ville, Tanila, Heikki, Haapasalo, Annakaisa, Hiltunen, Mikko
Publicado 2018

l-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia

por Huttunen, Johanna, Peltokangas, Soile, Gynther, Mikko, Natunen, Teemu, Hiltunen, Mikko, Auriola, Seppo, Ruponen, Marika, Vellonen, Kati-Sisko, Huttunen, Kristiina M.
Publicado 2019

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

por Gabbouj, Sami, Ryhänen, Simo, Marttinen, Mikael, Wittrahm, Rebekka, Takalo, Mari, Kemppainen, Susanna, Martiskainen, Henna, Tanila, Heikki, Haapasalo, Annakaisa, Hiltunen, Mikko, Natunen, Teemu
Publicado 2019

Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS

por Rostalski, Hannah, Leskelä, Stina, Huber, Nadine, Katisko, Kasper, Cajanus, Antti, Solje, Eino, Marttinen, Mikael, Natunen, Teemu, Remes, Anne M., Hiltunen, Mikko, Haapasalo, Annakaisa
Publicado 2019

MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation

por Wittrahm, Rebekka, Takalo, Mari, Marttinen, Mikael, Kuulasmaa, Teemu, Mäkinen, Petra, Kemppainen, Susanna, Martiskainen, Henna, Rauramaa, Tuomas, Pike, Ian, Leinonen, Ville, Natunen, Teemu, Haapasalo, Annakaisa, Hiltunen, Mikko
Publicado 2021

Decreased plasma C‐reactive protein levels in APOE ε4 allele carriers

por Martiskainen, Henna, Takalo, Mari, Solomon, Alina, Stančáková, Alena, Marttinen, Mikael, Natunen, Teemu, Haapasalo, Annakaisa, Herukka, Sanna‐Kaisa, Kuusisto, Johanna, Soininen, Hilkka, Kivipelto, Miia, Laakso, Markku, Hiltunen, Mikko
Publicado 2018

In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury—Lessons Learned

por Lipponen, Anssi, Natunen, Teemu, Hujo, Mika, Ciszek, Robert, Hämäläinen, Elina, Tohka, Jussi, Hiltunen, Mikko, Paananen, Jussi, Poulsen, David, Kansanen, Emilia, Ekolle Ndode-Ekane, Xavier, Levonen, Anna-Liisa, Pitkänen, Asla
Publicado 2019

Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury

por Kyyriäinen, Jenni, Kajevu, Natallie, Bañuelos, Ivette, Lara, Leonardo, Lipponen, Anssi, Balosso, Silvia, Hämäläinen, Elina, Das Gupta, Shalini, Puhakka, Noora, Natunen, Teemu, Ravizza, Teresa, Vezzani, Annamaria, Hiltunen, Mikko, Pitkänen, Asla
Publicado 2021

Effects of NR1H3 Genetic Variation on the Expression of Liver X Receptor α and the Progression of Alzheimer's Disease

por Natunen, Teemu, Martiskainen, Henna, Sarajärvi, Timo, Helisalmi, Seppo, Pursiheimo, Juha-Pekka, Viswanathan, Jayashree, Laitinen, Marjo, Mäkinen, Petra, Kauppinen, Tarja, Rauramaa, Tuomas, Leinonen, Ville, Alafuzoff, Irina, Haapasalo, Annakaisa, Soininen, Hilkka, Hiltunen, Mikko
Publicado 2013

BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci

por Rostalski, Hannah, Hietanen, Tomi, Leskelä, Stina, Behánová, Andrea, Abdollahzadeh, Ali, Wittrahm, Rebekka, Mäkinen, Petra, Huber, Nadine, Hoffmann, Dorit, Solje, Eino, Remes, Anne M., Natunen, Teemu, Takalo, Mari, Tohka, Jussi, Hiltunen, Mikko, Haapasalo, Annakaisa
Publicado 2020

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ

por Marttinen, Mikael, Ferreira, Catarina B., Paldanius, Kaisa M. A., Takalo, Mari, Natunen, Teemu, Mäkinen, Petra, Leppänen, Luukas, Leinonen, Ville, Tanigaki, Kenji, Kang, Gina, Hiroi, Noboru, Soininen, Hilkka, Rilla, Kirsi, Haapasalo, Annakaisa, Hiltunen, Mikko
Publicado 2020

Genetic Loci Associated with Alzheimer’s Disease and Cerebrospinal Fluid Biomarkers in a Finnish Case-Control Cohort

por Elias-Sonnenschein, Lyzel S., Helisalmi, Seppo, Natunen, Teemu, Hall, Anette, Paajanen, Teemu, Herukka, Sanna-Kaisa, Laitinen, Marjo, Remes, Anne M., Koivisto, Anne M., Mattila, Kari M., Lehtimäki, Terho, Verhey, Frans R. J., Visser, Pieter Jelle, Soininen, Hilkka, Hiltunen, Mikko
Publicado 2013

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

por Martiskainen, Henna, Paldanius, Kaisa M. A., Natunen, Teemu, Takalo, Mari, Marttinen, Mikael, Leskelä, Stina, Huber, Nadine, Mäkinen, Petra, Bertling, Enni, Dhungana, Hiramani, Huuskonen, Mikko, Honkakoski, Paavo, Hotulainen, Pirta, Rilla, Kirsi, Koistinaho, Jari, Soininen, Hilkka, Malm, Tarja, Haapasalo, Annakaisa, Hiltunen, Mikko
Publicado 2017

Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques

por Natunen, Teemu, Martiskainen, Henna, Marttinen, Mikael, Gabbouj, Sami, Koivisto, Hennariikka, Kemppainen, Susanna, Kaipainen, Satu, Takalo, Mari, Svobodová, Helena, Leppänen, Luukas, Kemiläinen, Benjam, Ryhänen, Simo, Kuulasmaa, Teemu, Rahunen, Eija, Juutinen, Sisko, Mäkinen, Petra, Miettinen, Pasi, Rauramaa, Tuomas, Pihlajamäki, Jussi, Haapasalo, Annakaisa, Leinonen, Ville, Tanila, Heikki, Hiltunen, Mikko
Publicado 2020