Targeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisons

por Gokare, Prashanth, Navaraj, Arunasalam, Zhang, Shengliang, Motoyama, Noboru, Sung, Shen-Shu, Finnberg, Niklas K.
Publicado 2016

AMG-232 sensitizes high MDM2-expressing tumor cells to T-cell-mediated killing

por Sahin, Ilyas, Zhang, Shengliang, Navaraj, Arunasalam, Zhou, Lanlan, Dizon, Don, Safran, Howard, El-Deiry, Wafik S.
Publicado 2020

Correction: AMG-232 sensitizes high MDM2-expressing tumor cells to T-cell-mediated killing

por Sahin, Ilyas, Zhang, Shengliang, Navaraj, Arunasalam, Zhou, Lanlan, Dizon, Don, Safran, Howard, El-Deiry, Wafik S.
Publicado 2020

Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo

por Jhaveri, Aakash V., Zhou, Lanlan, Ralff, Marie D., Lee, Young S., Navaraj, Arunasalam, Carneiro, Benedito A., Safran, Howard, Prabhu, Varun V., Ross, Eric A., Lee, Seulki, El-Deiry, Wafik S.
Publicado 2021

Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells

por Zhou, Lanlan, Huntington, Kelsey, Zhang, Shengliang, Carlsen, Lindsey, So, Eui-Young, Parker, Cassandra, Sahin, Ilyas, Safran, Howard, Kamle, Suchitra, Lee, Chang-Min, Lee, Chun Geun, Elias, Jack A., Campbell, Kerry S., Naik, Mandar T., Atwood, Walter J., Youssef, Emile, Pachter, Jonathan A., Navaraj, Arunasalam, Seyhan, Attila A., Liang, Olin, El-Deiry, Wafik S.
Publicado 2020

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection

por Zhou, Lanlan, Huntington, Kelsey, Zhang, Shengliang, Carlsen, Lindsey, So, Eui-Young, Parker, Cassandra, Sahin, Ilyas, Safran, Howard, Kamle, Suchitra, Lee, Chang-Min, Geun Lee, Chun, A. Elias, Jack, S. Campbell, Kerry, T. Naik, Mandar, J. Atwood, Walter, Youssef, Emile, A. Pachter, Jonathan, Navaraj, Arunasalam, A. Seyhan, Attila, Liang, Olin, El-Deiry, Wafik S.
Publicado 2020