Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer

por Cheng, Qing, Chang, Jeffrey T, Geradts, Joseph, Neckers, Leonard M, Haystead, Timothy, Spector, Neil L, Lyerly, H Kim
Publicado 2012

NMR Methods for Determining Lipid Turnover via Stable Isotope Resolved Metabolomics

por Lin, Penghui, Dai, Li, Crooks, Daniel R., Neckers, Leonard M., Higashi, Richard M., Fan, Teresa W-M., Lane, Andrew N.
Publicado 2021

Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy

por Zhang, Ting, Yang, Xinrui, Xu, Wanping, Wang, Jing, Wu, Dawei, Hong, Zhixian, Yuan, Shengxian, Zeng, Zhen, Jia, Xiaodong, Lu, Shanshan, Safadi, Rifaat, Han, Sen, Yang, Zhihong, Neckers, Leonard M., Liangpunsakul, Suthat, Zhou, Weiping, Lu, Yinying
Publicado 2021

HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study

por Osada, Takuya, Crosby, Erika J., Kaneko, Kensuke, Snyder, Joshua C., Ginzel, Joshua D., Acharya, Chaitanya R., Yang, Xiao-Yi, Polascik, Thomas J., Spasojevic, Ivan, Nelson, Rendon C., Hobeika, Amy, Hartman, Zachary C., Neckers, Leonard M., Rogatko, Andre, Hughes, Philip F., Huang, Jiaoti, Morse, Michael A., Haystead, Timothy, Lyerly, H. Kim
Publicado 2022

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

por Oshima, Nobu, Ishida, Ryo, Kishimoto, Shun, Beebe, Kristin, Brender, Jeffrey R., Yamamoto, Kazutoshi, Urban, Daniel, Rai, Ganesha, Johnson, Michelle S., Benavides, Gloria, Squadrito, Giuseppe L., Crooks, Dan, Jackson, Joseph, Joshi, Abhinav, Mott, Bryan T., Shrimp, Jonathan H., Moses, Michael A., Lee, Min-Jung, Yuno, Akira, Lee, Tobie D., Hu, Xin, Anderson, Tamara, Kusewitt, Donna, Hathaway, Helen H., Jadhav, Ajit, Picard, Didier, Trepel, Jane B., Mitchell, James B., Stott, Gordon M., Moore, William, Simeonov, Anton, Sklar, Larry A., Norenberg, Jeffrey P., Linehan, W. Marston, Maloney, David J., Dang, Chi V., Waterson, Alex G., Hall, Matthew, Darley-Usmar, Victor M., Krishna, Murali C., Neckers, Leonard M.
Publicado 2020